mobilejdral

7 ms·

1.
by mobilejdral 5d ago
This comment was perhaps written by an LLM that has learned it can karma farm by pointing out all of the articles that have LLM usage while everyone still thinks that is a novel contribution.
2.
by mobilejdral 6mo ago
I spent the entire time reading it pondering the same thing. 1. The article presents that calling out to a tool like python is "expensive" because of the overhead of forking a process, loading up the python env etc, but why not ju
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by mobilejdral 7mo ago
Having worked on software that runs manufacturing plants your comment echos the idea that too many engineers have that they are "better" than manufacturing and lessons don't apply to them. Go back to your desk and work on a P
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by mobilejdral 7mo ago
Depends on the microplastics, but many act as endocrine disruptors that "mimic" estrogen, tricking the body into over-activating ERa and upregulates the PEMT gene and the higher acetylcholine. It could also be that the microplast
5.
by mobilejdral 7mo ago
The non-DHA omega-3 EPA are good at preventing perivascular fibrosis and thus a better glymphatic system for the removal of beta-amyloid proteins. EPA also helps produce melatonin which kick off sleep and this whole process. Natto-serrazim
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by mobilejdral 8mo ago
It depends on the person and their genetics. The further you get from the ERa the more complicated this gets and simply stating "Do X" wouldn't apply to everyone even if there are some incredibly common things to do. I migh
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by mobilejdral 8mo ago
ERa activation promotes PGE2 resulting in decreased 15-PGDH. So this is one of those standard poor estrogen signaling downstream things and simply improving the estrogen signaling and you get improved cartilage. Anyone can do this today alo
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by mobilejdral 11mo ago
I am not saying that if there was a pill on the market today that would increase plaque-clearing there wouldn't still be dementia, simply that they would probably then die from pneumonia. One needs to also dive into neurogenesis. Eleva
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by mobilejdral 11mo ago
For this particular situation on D3 I personally (who is not your doctor) would go with vitamin D3-loaded nanoemulsion. The reason is that Vit D influences how tryptophan is converted down the 5-HTP and serotonin path or the Kynurenine pat
10.
by mobilejdral 11mo ago
The title is a bit link-bait. It should really be "Disrupting circadian rhythms of plaque-clearing brain cells is associated with Alzheimer's" > He found that too much of YKL-40, which is linked to Alzheimer’s risk in hum
11.
by mobilejdral 1y ago
Neanderthals had the FOXP2 gene, which is associated with speech and language.
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by mobilejdral 1y ago
And then this ties to estrogen, HRT is known to reduce the risk of dementia/AD ( https://pmc.ncbi.nlm.nih.gov/articles/PMC10480684/ ). PEMT (phosphatidylethanolamine N-methyltransferase) is what makes choline i
13.
by mobilejdral 1y ago
Tying this to APOE, specifically e4 which has an increased requirement for choline and when choline levels are low there can be a metabolic push that leads to elevated PHGDH activity and consequently, increased serine synthesis. That is a
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by mobilejdral 1y ago
Think questions where there is a ton of existing medical research, but no clear answer yet. There are a dozen alzheimer's questions you could for example ask which would require it to pull in a half dozen contradictory sources into a
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by mobilejdral 1y ago
I have a several complex genetic problems that I give to LLMs to see how well they do. They have to reason though it to solve it. Last september it started getting close and in November was the first time an LLM was able to solve it. The
16.
by mobilejdral 1y ago
Sure, add a way to contact you to your account and I can send you over the current understanding.
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by mobilejdral 1y ago
The author also asks "If you were stranded on an island (or small hostile planetoid), what books would you want to have with you?" which I also can't answer. I would fall into the category of someone who does research as leis
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by mobilejdral 1y ago
3 of the 4 dna samples show signs of nonclassic CAH. This limited their reproduction abilities as 50% of babies would have CAH and die at birth until they integrated with proto-humans and had higher genetic diversity.
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by mobilejdral 2y ago
If you mean ring type I don't remember which one worked best, sorry. As for my favorite EM field there is a nearby street with buried powers lines and transformer boxes at ground level. As you walk the street to the main street each b
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by mobilejdral 2y ago
I have had one of these for years and the right size makes all the difference. Some fun things include the ability to feel where the metal studs are in building walls, where the electrical lines are under the ground and of course the micro
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by mobilejdral 2y ago
Because there was general layoffs of the workers in the previous year or two? There is a fairly formulaic way that companies tighten belts. First you do layoffs, get rid of projects that will never make money, reduce headcount for orgs t
22.
by mobilejdral 2y ago
Naltrexone in high doses takes away all pleasure by blocking opioid receptors (low doses do too, but it is different when only a few hours). So there is no reward for drinking or eating if that is why you are eating. If this is not why yo
23.
by mobilejdral 2y ago
Actual paper: https://pubmed.ncbi.nlm.nih.gov/39235810/ > Conclusions and relevance: In this cohort study, a history of upper gastrointestinal MD was associated with elevated risk of developing a clinical PD diagnos
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by mobilejdral 2y ago
That is so wild to me. I only consume media there if I am sent a link. Every time I have gone there I find content that is literally optimized to use up and waste as much of my time as possible under the incentive of maximizing viewer m
25.
by mobilejdral 2y ago
Some feedback: In the readme file at the top you want to describe the problems that Grace solves. This is what I read and parsed: > cloud-native version control system. Not a problem I thought I needed to solve, but okay. Also this me
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by mobilejdral 2y ago
> Its what nature intends A better question is if it is a fitness advantage to die. And it is. If you have two species and the first dies when something happens and the second doesn't the first will "win". The first spe
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by mobilejdral 2y ago
Can I ask you your thoughts about CYP21A2? Been studying folks with only one working CYP21A2 due to the resulting atypical adrenal function and I noticed that their dna also contains all the genetic variants associated with Alzheimer's
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by mobilejdral 3y ago
Only hiring cis white men from your local network or only recruiting from the college that only allows men is by definition sexist and racist. The point of DEI is to first try to teach and then to punish managers that are stupid and say tha
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by mobilejdral 3y ago
There is the long standing joke around the Geeks and Jocks. The don't usually have sex with each other. Genetically they have even diverged with genetic attributes that you typically find in one and not the other. They are even mo
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by mobilejdral 3y ago
It took me way to long to find the ingredient list for the Athletic Greens starting from the main page. Even on the actual page itself you have to click a button to see it. https://drinkag1.com/about-ag1/ingredients&#

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