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Intravenous Caffeine
- engineer_22 3y agoTLDR; participants with cocaine history were administered caffeine IV. At high doses (300mg) they reported some mild euphoria, and a strange taste and/or smell. Ask HN: aside from caffeine, what is the drug of choice around here?
- boredemployee 3y agometh and adderall
- zeta0134 3y agoMusic. String ensembles are the best, choir is a close second. Rapid response, mild euphoria, no unpleasant side effects. Repeated exposure can induce fatigue, making it an excellent sleep aid.
- zhynn 3y agoleverage.
- hammock 3y ago> high doses (300mg) What's the equivalent of a 300mg IV dose in oral ingestion?
- engineer_22 3y agoPer article it's 4-5 shots of espresso. Apparently caffeine is absorbed quickly by the gut, so if you shoot it all down at once, you'd get similar results.
- deleted 3y ago[deleted]
- bigdict 3y agoAI hype
- kenniskrag 3y agochocolate
- awestroke 3y agoArrogance
- sdwr 3y agoThat's the good stuff!
- thedrexster 3y agoLSD is my happy place -- and Adderall, but I've a prescription for that one!
- suslik 3y agoMicrodosing?
- deafpolygon 3y agocrypto laced with AI
- JLCarveth 3y agoI doubt you'll get too many serious replies, but as a Canadian my DoC is cannabis.
- cactusplant7374 3y agoketamine
- ycombinete 3y agoMethylphenidate
- mock-possum 3y agoI’ve settled upon: Caffeine at work, alcohol not at work, molly to party with friends, weed to party on my own.
- PKop 3y agoRunning, hiking, lifting
- themodelplumber 3y agoSerious? I pre & post all of those + bicycling. Whammy, huge difference, especially if you leverage e.g. the caffeine for mental work, or whatever else each chemical is good at. Had some funny experiments in there but would never go back to nothing. It doesn't make sense, especially if you don't have an addictive personality & any chemical risk is more likely associated with quitting beneficial chemicals than staying on them too long.
- nologic01 3y agoopen source utopia
- BenFeldman1930 3y agoBooks.
- deleted 3y ago[deleted]
- isoprophlex 3y agoweb3 projects not working out; schadenfreude in general; the smell of my own farts.
- uoaei 3y agoMushrooms
- ehPReth 3y agobenzodiazepines.
- zwieback 3y agoZungenwurst, can't get enough of it
- gpas 3y agoCaffeine, nicotine, thc and alcohol.
- tasty_freeze 3y agoTHC containing gummies, once a week, for music enhancement before bed. Tangential details... The 2018 hemp farm bill allows products to have up to 0.3% THC, but it took years for people to realize that gummies are hefty enough that 0.3% means a gummy can have 10-20mg of THC. So, at the ripe age of 57 I finally tried THC. It was very frustrating because most of the good stuff I expected didn't happen: no euphoria, no munchies, no relaxation. I do get some of the negative things, like dry mouth. The one good thing I get is music enhancement, but only if I do it once a week or less (10-15mg). I've tried doing it more frequently and upping the dose to compensate, but nope: if I invoke the genie too frequently he refuses to come out of the bottle.
- zls 3y agoI’m surprised you do it before bed! I find that especially with edibles, using thc too close to bed makes me sleep deeply but wake up groggy. Typically I need an afternoon nap the next day. I believe thc fucks with REM. Food is totally unchanged for you? Wild! What about movies/tv?
- recursive_loops 3y agoI get very little effect from weed unless I take a huge amount, in which case I also feel miserable with "too much" symptoms. It just doesn't seem to work for some people
- tasty_freeze 3y agoYup, it isn't enhanced at all, and I don't get extra cravings. Although I gone up to 25mg while I was experimenting to find a dose that works best for me, my target is 10mg. Maybe that isn't enough to trigger munchies. Because the only thing I find it good for is music enhancement, I like to take a gummy around 9pm-10pm, then two hours later put on three albums with a particular kind of music, then hope that I get enhancement. If I'm feeling tired that day, though, I put it off because sucks to hit the sweet spot and then immediately fall asleep and not get to enjoy the music. By enhancement, I mean I experience pronounced stereo separation and deeper notes seem to be very resonant. Sometimes I get little floaty and feel like I'm suspended in zero gravity while I drift to the music. Because I do it only once a week, I don't notice any disruption of my sleep. EDIT: you asked about TV/movies. I don't watch them, so I don't know.
- deleted 3y ago[deleted]
- willcipriano 3y agoAdrenochrome
- mtlmtlmtlmtl 3y agoLow dose dextro-amphetamine for ADHD in everyday life, weed for music and various other enjoyment, only occasionally. Alcohol and whatever nose-friendly stimulants are available for parties. Psychedelics at most annually(ideally 2C-B or (1p-)LSD, but I've tried a whole host of different ones) for deep contemplation and introspection. Watching my brother destroy his life with Heroin has kept me away from opioids for the most part, but I don't like the way they make me feel anyway.
- recursive_loops 3y agoOpioids are no joke for sure. If you have good self discipline and can limit yourself to one every 2 to 3 days, it can be amazing and safe. But it makes you feel really good and many people don't have the self control required, so I recommend staying away. If you develop a physical dependence, it is not pleasant to say the least.
- mtlmtlmtlmtl 3y agoI mean I've tried opioids, but they make me nauseous. And tired. And i specifically avoided trying really strong ones because yeah, I know I wouldn't be able to handle it. It took years of suffering even to be able to control my cannabis use...
- hoosieree 3y agoSuccessful debugging session euphoria.
- oramit 3y agoCaffeine pretty much every day, I can only have it in the mornings though or it interferes with sleep. Alcohol a few times a week, usually just one or two drinks. Now that i'm mid thirties the booze hits me much harder than before and hangovers are easy to get. Pot gummies on the weekend when I want to relax. I know quite a few heavy users who will smoke a couple joints then go do yardwork - crazy. If I have any i'm eating a heavy meal and playing video games. I sleep great with it. I started smoking cigars over the pandemic, only a couple times a month, you certainly get a nicotine buzz that is kind of nice. It is smelly though so I don't do it often and it's more for the ritual and relaxation than the buzz. Amyl nitrates for other recreation. Wow writing that all out makes me look like a degenerate :)
- deleted 3y ago[deleted]
- kayodelycaon 3y agoPersonally, prescription medications are great: legal, consistent, safe, and effective. Wellbutrin (NDRI) every morning. Helps with attention and alertness. It isn't classified as a stimulant, so I don't need to deal with the regulations around regular ADHD meds. It also helps with sexual dysfunction caused by other meds. Benzos for social events. Way better than alcohol. All of the chill and none of the impairment. :)
- zhynn 3y agokratom.
- matheusmoreira 3y agoPrescription amphetamines.
- loves_mangoes 3y agoI had heard that there's a community of people who insufflate caffeine on Reddit, but this one is news to me. Seems a little funny to go through all the trouble and extreme stigma of injecting yourself with an IV drug, only to pick ground up coffee beans as your poison of choice (!) The study is interesting mostly for the fact that someone tried it, but ultimately the results don't show a very strong effect. I wouldn't put too much confidence in how well it would replicate either, these kind of studies can have a lot of variation. >Every drug seems to have a “right” way to take it. You [...] booty bump ecstasy That is not really typical. People normally eat it as ecstasy pills, or as MDMA powder. Most recreational drugs can be taken rectally, that usually makes for a higher bio-availability and a faster peak plasma concentration. Some people do that a lot, with everything. It is not specific to ecstasy, that I know of.
- germinalphrase 3y agoA paramedic friend advised that if you ever end up in the hospital in a lot of pain, always opt for the suppository.
- TurkishPoptart 3y agoWhat's the reasoning? Instead of an IV? If I was in extreme pain, I would by default opt for an IV, which would be the fastest way to relieve it.
- germinalphrase 3y agoI guess I misspoke a bit in the original comment. Yea - in the hospital, they’ll just inject if possible; however, if a doctor is writing a prescription and you’re offered pills vs a suppository, take the suppository.
- stronglikedan 3y agoYour friend isn't wrong. It's pretty much a direct blood vessel highway to the brain.
- valine 3y agoI experience a chalky scent from high dose caffeine pills. I don’t think the taste is unique to the intravenous caffeine.
- brnaftr361 3y agoSame, and on occasion I have had coffee do the same. That's if I'm reading this correctly and you're describing the smell in your blood?
- valine 3y agoI assume so, either that or its neurological. Its like the scent comes from inside my head.
- joecool1029 3y agoAre they pure or adulturated with calcium? Most of the caffeine pills I've spotted are not just caffeine and I think this is the chalkiness you would be experiencing.
- valine 3y agoThey’re pure as far as I know. Would calcium be listed as an ingredient?
- travisjungroth 3y agoIt’s very unlikely they’re pure caffeine. If it’s a pressed pill (versus a capsule) they’re definitely not. It needs binders to hold it together.
- valine 3y agoGotcha, I take capsules. They’ve got rice powder to add volume I assume, but other than that I think it’s pure caffeine.
- 3y ago
- xattt 3y agoNot mentioned in the article, but IV caffeine citrate is routinely used as a drip to support hypoventilating pre-term neonates.
- rossdavidh 3y agoYes, my daughter (born several months prematurely) was given caffeine for a while. The nurses described it to me as "reminding her heart to keep beating and her lungs to keep working", since she was so premature that it wasn't something they were supposed to have to do without the mother's help yet. My wife, who had gone through significant discomfort in order to cut off caffeine while pregnant (she was told otherwise the baby could be born already addicted to caffeine), was a bit exasperated when told that almost the first thing they did was give her daughter a caffeine IV. It was probably still the right thing for her to have done (so the caffeine IV had full affect), but I could sympathize with her position.
- carimura 3y agoCoffee enemas are apparently an influencer thing right now.
- jandrese 3y agoWhenever I hear something like this my first thought is that it's some stupid TikTok "challenge" that's intended to get people to humiliate/injure themselves on camera for the lols.
- ikmckenz 3y agoCoffee enemas were a big thing in the 90s. The coffee is not hot (obviously). But you’d be correct to think there’s no benefit.
- salad-tycoon 3y agoThere was a show called “my weird addiction” or something similar. A young good looking couple would frequently take breaks to do coffee enemas. She likes “Java” or something, he preferred something else and more like espresso. I think they had a kid. Only episode I ever watched. What a treat.
- haskellandchill 3y agoIV drugs, not for the feint of heart. Even with a good technique you will eventually blow up your spot and need to go fishing, then it gets horrific.
- amelius 3y agoSo, getting the downsides of coffee without the upsides of drinking it?
- ttymck 3y agoAh yes the venerable tooth decay upside.
- HPMOR 3y agoCoffee doesn't cause tooth decay. Sugar causes tooth decay. You can drink Coffee without sugar.
- slabity 3y agoNot a dentist, but I think it's the acid that causes tooth decay. Microbes create the acid from dissolved sugar in your mouth. The question is whether coffee is acidic enough to do damage even without the sugar.
- waboremo 3y agoI believe the common theory is not the coffee acidity on its own, but the habits around it. People often drink coffee slowly and without a straw, this leads to staining but not tooth decay. However the slow part contributes to the teeth not getting a chance to neutralize acidity normally. This gets worse when people then brush their teeth after their morning coffee to prevent bad breath, which the abrasiveness combined with the acid environment does cause havok. Both of them can be avoided in a variety of ways, to reduce both staining and decay.
- joaonmatos 3y agoYou can have your espresso standing up at the café's bar like an authentic southern European and avoid the problem? Sounds great! :D
- ziml77 3y ago
- ano-ther 3y agoDidn’t realise caffeine was used IV in anesthesia. Apparently it speeds up awakening (which makes sense to me as a non-medic). https://theanesthesiaconsultant.com/2019/06/18/intravenous-caffeine-following-general-anesthesia/ https://theanesthesiaconsultant.com/2019/06/18/intravenous-c... But the story in OP is that the patient received caffeine IV at the beginning of the surgery (inducing severe anxiety). Does anyone know why you would do this?
- IIAOPSW 3y agoMaybe someone put the wrong IV in?
- flangola7 3y agoEpinephrine increases the strength of painkillers. That's why there's caffeine in Excedrin.
- freedomben 3y agoI thought the caffeine was there to restrict/narrow blood vessels which usually helps with migraines. Multi-purpose maybe?
- cjbgkagh 3y agoAFAIK, I think it depends on where in the body, vasoconstriction in the head vasodilation for the rest of the body.
- etskinner 3y agoWhat does epinephrine have to do with caffeine?
- cloudwalk9 3y agoCaffeine directly kickstarts the adrenal glands
- deleted 3y ago[deleted]
- AlbertCory 3y agoAnecdote: someone told me she knew some nurses and they knew a quick way to get over hangovers. Quite illegal, but it involves IV. Don't come at me: I'm not recommending this, I've never done it, and your nurse friends probably won't do it for you. Edit: TIL it's not illegal. However, in a hospital I'm pretty sure the nurses aren't supposed to do it for free.
- er4hn 3y agoIllegal where? This is a "show up to your hotel room" service you can get in Las Vegas.
- fullspectrumdev 3y agoIt’s legal - I’ve stayed at hotels even in London where you can get a nurse administered IV of some bullshit in your room. I passed on that, and went with the time honoured method of a greasy fry and a pint. The illegal part is if the nurse is stealing the IV and “works” from their workplace (a hospital).
- justinator 3y agoThere are IV bars in Colorado so not all that illegal (doing at home: yeah a little different). You can get just a reg. IV, or vitamins - that sort of thing. Being at a high altitude, hangovers suck up here, so there may be a market. I don't drink anymore - and it wasn't a hard decision. I haven't been down to sea level in a very long time, but drinking is completely different up here than down there.
- DangitBobby 3y agoIt's not illegal here. They advertise it in bar restrooms as a "hangover and extreme sports recovery" treatment.
- freedomben 3y agowhat's the way? just rehydration drip? that's widely known and there's nothing illegal about it if you have the equipment
- 3y ago
- shagie 3y agoAt a meeting where Electronic Medical Records was on the agenda, I happened to have been sitting next to a manager involved with that and joked about that you can't take ICD-10-CM Diagnosis Code T43.616A ( Underdosing of caffeine, initial encounter https://www.icd10data.com/ICD10CM/Codes/S00-T88/T36-T50/T43/T43.6-/T43.616A https://www.icd10data.com/ICD10CM/Codes/S00-T88/T36-T50/T43/... ) to Starbucks with a prescription. He chuckled a bit and told a tale of when he actually had that show up on his hospital visit once. He was in the hospital for some reason. That next morning he was rather grumpy and after snapping at the doctor apologized and noted that it was 2 hours after he normally had his morning coffee... which he couldn't have. The doctor asked if he'd be better if he had some caffeine and the manager said "probably." So T43.616A showed up on his chart and shortly after that a nurse came by and added one cup of coffee caffeine equivalent to his IV. Apparently it degrumped the manager sufficiently shortly afterwards. The IV was much more than the cup of coffee from Starbucks and there was some dickering with insurance about if that was a necessary or elective treatment. He concluded with that he wouldn't recommend it again.
- yellow_lead 3y ago> added one cup of coffee caffeine equivalent to his IV. > The IV was much more than the cup of coffee To be clear you mean about same concentration i.e 100mg but higher absorption?
- chimeracoder 3y ago> To be clear you mean about same concentration i.e 100mg but higher absorption? I think he means that the IV caffeine cost much more than a cup of Starbucks would have.
- akiselev 3y agoStarbucks is like $5 per 100-200mg. IV caffeine is like $500 per 100-200mg.
- firstlink 3y agoAnd pills are like $0 per 100-200mg, so we know why the hospital didn't just use those.
- sethbannon 3y agoI was curious about the booty bumping of ecstasy comment. https://goaskalice.columbia.edu/answered-questions/plugging-ecstasy/ https://goaskalice.columbia.edu/answered-questions/plugging-...
- rejectfinite 3y agoCaffine pills are cheap af...
- ChrisMarshallNY 3y agoSounds like one of these "cocktails": https://www.ivbars.com/cocktails https://www.ivbars.com/cocktails
- netcraft 3y agoI recently had a nuclear stress test where they injected me with a radioactive tracer through an IV. The nurse told me that sometimes it can give you a pretty wicked headache and to let them know if I started having any pain and they would give me caffeine through my IV. I had needed to abstain from any caffeine for 24-48 hours ahead of the test so this was surprising to me - but luckily I didn't need it through the IV. But I really wondered what it would feel like...
- pcthrowaway 3y ago> Every drug seems to have a “right” way to take it. You drink alcohol, smoke tobacco, snort powdered cocaine, inject heroin, and booty bump ecstasy Nicotine at least is probably more commonly consumed via alternative means now (in North America, in <40 demographics at the very least) Vaping would likely be the most common, but there are also patches, gum, lozenges, dip, and snuff. I've never heard of anally consumed nicotine though
- cperciva 3y agoI've never heard of anally consumed nicotine thoug Never heard of blowing smoke up someone's ass? It was literal in the 18th century.
- crazygringo 3y agoWow, I thought for sure that would turn out to be an urban legend, but it's real and was medical: > ...it was a general mainstream medical procedure used to, among many other things, resuscitate people who were otherwise presumed dead. In fact, it was such a commonly used resuscitation method for drowning victims particularly... Smoke was blown up the rectum by inserting a tube. This tube was connected to a fumigator and a bellows which when compressed forced smoke into the rectum. Sometimes a more direct route to the lungs was taken by forcing the smoke into the nose and mouth, but most physicians felt the rectal method was more effective. The nicotine in the tobacco was thought to stimulate the heart to beat stronger and faster, thus encouraging respiration... Artificial respiration was used if the tobacco enema did not successfully revive them. [1] So it's not like it was for fun. But I can see how for fast delivery of nicotine, it made perfect sense. [1] https://gizmodo.com/blowing-smoke-up-your-ass-used-to-be-literal-1578620709 https://gizmodo.com/blowing-smoke-up-your-ass-used-to-be-lit...
- salad-tycoon 3y agoThere’s also nasal spray and I think drinks in Japan. Snuff (nose) is big India I believe. If you stretch out your hand and fingers and draw a line down from your index and thumb there’s the radial fossa aka “anatomical snuffbox.” I’ve never done rectal or IV nicotine but I’ve done all the rest. For my money, the Swedes make the best smokeless tobacco. I’m guessing it’s big there?
- vijucat 3y ago> Most people consume ecstasy by mouth, but I’ve heard from many that anal ecstasy is a more satisfying experience. I don't know why now and why this, but this has convinced me that I really need to cut down on what I read online. 99% of it does not go towards my life objectives and 100% of it is probably taking up space in my brain. To be clear, I would have laughed at that fact and moved on before. It just hit me differently today; I could be thinking about my family, work, friends, whatever, but now I know some irrelevant fact about ingesting drugs via the butt.
- pharrington 3y agoI guess I don't understand why people are shocked to learn that recreational drugs can be ingested rectally, but don't bat an eye about the existence of medicinal suppositories. (Or maybe people are shocked to find out about suppositories?)
- novia 3y agoYou've missed the point. The GP is saying that consuming data at random does not contribute towards the things they personally prioritize in life.
- splendor_spoon 3y agoAnd yet they still took the time to write out a comment explaining their conclusion. Maybe they are not quite there yet on their priorities!
- SantalBlush 3y agoI fail to see the hypocrisy in the above comment, but maybe you can clarify your reasoning.
- 2devnull 3y agoUnderstandable given the url and post title. Person is thinking, man what would matter in life right now is intravenous caffeine, let’s see what “sexdrugssuicide.com” can help me with. And shockingly, it didn’t really change their life after all. I hate that.
- pgl 3y agoI think this may be referring to this study: https://pubmed.ncbi.nlm.nih.gov/29206091/ https://pubmed.ncbi.nlm.nih.gov/29206091/ "Effects of caffeine administration on sedation and respiratory parameters in patients recovering from anesthesia" > Caffeine has been shown to enhance the speed of recovery from general anesthesia in murine models, though data in human patients is lacking. This is a retrospective review of intravenous caffeine administration (median dose 150 [125, 250] mg) to 151 heavily sedated patients in the post-anesthesia recovery area, to determine the association between caffeine administration and changes in sedation score, respiratory rate, and oxyhemoglobin saturation.
- zgs 3y agoA guy I know once suggested a wet suit and a caffeinated bath. By the time you release you've had too much, you're not even halfway there.
- waynecochran 3y agoMigraine sufferer here. Been to the emergency room for bad headaches about 8 times. I get a cocktail of toroidal, benedryl, an caffeine by IV w a morphine chaser. Works.
- strangus 3y agoThe Bum's Rush.
- fithisux 3y agoReserach for cheaper drugs?
- iamnotsure 3y agoDrugs work or not due to symbolic context; which is not obvious, but can be inferred, when they actually do stop working and there is no scientific explanation for that.
- darawk 3y agoAs probably the only person on HN who has ever intentionally IV'd caffeine...I can confirm that it's not really that interesting. Just like regular caffeine, but slightly faster. Oral caffeine already absorbs pretty rapidly anyway.