7 ms·

Cool, but it's the lipid delivery system that is the secret sauce. This is equivalent to giving the source code without a compiler to build it.

airhead969 5y ago
Wouldn't the "compiler" be the bioreactor used to mass-produce it and the "installer" be the lipid encapsulation? :)
- snuxoll 5y ago
  InstallGene by Flexera
  - Haemm0r 5y ago
    Just waiting for first copy protection mechanism for mRNA. SafeGene and SecuGene here we come :o
    - aneutron 5y ago
      Can you imagine, the greedy folk would want some sort of Widevine in humans.
      - Haemm0r 5y ago
        The vaccine will check your implanted payment chip receipt number before activating the payload.
      - airhead969 5y ago
        "Drink Brawndo, The Thirst Mutilator." in your DNA too. Sony is gonna sneak in some DRM and Mark Russinovich is gonna put out a fix.
    - airhead969 5y ago
      "The authorization server is down, no longer signing this version of this medication, or this medication has expired. Please contact your supplier for more information." Shit, I'm going to have to google for a working hex edit or look for a bpatch.
    - airhead969 5y ago
      Can't wait for the DNA "chip art" by gene designers. Considering we have so much HERV, they might use that as an equivalence rationalization to do it.
- ineedasername 5y ago
  Maybe the booster shot can be done with a simple apt-get update.
  - reddotX 5y ago
    a fellow linux user. ubuntu?
  - schappim 5y ago
    Got the “GPG Error: No Public Key” error. Probably for the best!
    - airhead969 5y ago
      Fawwwwwk. Gotta edit the /etc/apt/apt.conf.d/covid-19-vaccine.conf Anyone know if sudo works?
  - airhead969 5y ago
    Serious. Unless it requires a separate, native-compiled adaptive immunity package.
- deleted 5y ago
  [deleted]
- divbzero 5y ago
  In the case the bioreactor “compiler” is actually our own cells which read out the mRNA “source code” and translate it into protein. The lipid encapsulation delivers the mRNA to our cells, so perhaps it’s more analogous to a network protocol that delivers source code intact across firewalls and other defenses.
subroutine 5y ago
Meh, they probably just used lipofectamine (which has been around since the 90s) or something very similar. https://en.wikipedia.org/wiki/Lipofectamine https://en.wikipedia.org/wiki/Lipofectamine https://www.thermofisher.com/us/en/home/brands/product-brand/lipofectamine.html https://www.thermofisher.com/us/en/home/brands/product-brand...
- Duller-Finite 5y ago
  lipofectamine is used for in vitro transfection, not in vivo gene delivery. The vaccines use lipid nanoparticles rather than liposomes
  - MuffinFlavored 5y ago
    If they didn't use lipofectamine, what did they most likely use?
    - flobosg 5y ago
      Derek Lowe discussed it a few months ago: https://blogs.sciencemag.org/pipeline/archives/2021/01/11/rna-vaccines-and-their-lipids https://blogs.sciencemag.org/pipeline/archives/2021/01/11/rn... https://blogs.sciencemag.org/pipeline/archives/2021/02/22/more-on-mrna-vaccine-manufacturing https://blogs.sciencemag.org/pipeline/archives/2021/02/22/mo...
  - neuronic 5y ago
    I absolutely do not have a link, but I remember reading that the lipid nanoparticles are actually created by mechanical action (possibly fluid dynamics/turbulence). I thought that was pretty neat.
DrAwdeOccarim 5y ago
But wasn't the whole Pfizer/BioNTech "secret sauce" leaked online after the EMA was hacked?

airhead969 5y ago

Wouldn't the "compiler" be the bioreactor used to mass-produce it and the "installer" be the lipid encapsulation? :)

snuxoll 5y ago
InstallGene by Flexera
- Haemm0r 5y ago
  Just waiting for first copy protection mechanism for mRNA. SafeGene and SecuGene here we come :o
  - aneutron 5y ago
    Can you imagine, the greedy folk would want some sort of Widevine in humans.
    - Haemm0r 5y ago
      The vaccine will check your implanted payment chip receipt number before activating the payload.
    - airhead969 5y ago
      "Drink Brawndo, The Thirst Mutilator." in your DNA too. Sony is gonna sneak in some DRM and Mark Russinovich is gonna put out a fix.
  - airhead969 5y ago
    "The authorization server is down, no longer signing this version of this medication, or this medication has expired. Please contact your supplier for more information." Shit, I'm going to have to google for a working hex edit or look for a bpatch.
  - airhead969 5y ago
    Can't wait for the DNA "chip art" by gene designers. Considering we have so much HERV, they might use that as an equivalence rationalization to do it.
ineedasername 5y ago
Maybe the booster shot can be done with a simple apt-get update.
- reddotX 5y ago
  a fellow linux user. ubuntu?
- schappim 5y ago
  Got the “GPG Error: No Public Key” error. Probably for the best!
  - airhead969 5y ago
    Fawwwwwk. Gotta edit the /etc/apt/apt.conf.d/covid-19-vaccine.conf Anyone know if sudo works?
- airhead969 5y ago
  Serious. Unless it requires a separate, native-compiled adaptive immunity package.
deleted 5y ago
[deleted]
divbzero 5y ago
In the case the bioreactor “compiler” is actually our own cells which read out the mRNA “source code” and translate it into protein. The lipid encapsulation delivers the mRNA to our cells, so perhaps it’s more analogous to a network protocol that delivers source code intact across firewalls and other defenses.

subroutine 5y ago

Meh, they probably just used lipofectamine (which has been around since the 90s) or something very similar. https://en.wikipedia.org/wiki/Lipofectamine https://en.wikipedia.org/wiki/Lipofectamine https://www.thermofisher.com/us/en/home/brands/product-brand/lipofectamine.html https://www.thermofisher.com/us/en/home/brands/product-brand...

Duller-Finite 5y ago
lipofectamine is used for in vitro transfection, not in vivo gene delivery. The vaccines use lipid nanoparticles rather than liposomes
- MuffinFlavored 5y ago
  If they didn't use lipofectamine, what did they most likely use?
  - flobosg 5y ago
    Derek Lowe discussed it a few months ago: https://blogs.sciencemag.org/pipeline/archives/2021/01/11/rna-vaccines-and-their-lipids https://blogs.sciencemag.org/pipeline/archives/2021/01/11/rn... https://blogs.sciencemag.org/pipeline/archives/2021/02/22/more-on-mrna-vaccine-manufacturing https://blogs.sciencemag.org/pipeline/archives/2021/02/22/mo...
- neuronic 5y ago
  I absolutely do not have a link, but I remember reading that the lipid nanoparticles are actually created by mechanical action (possibly fluid dynamics/turbulence). I thought that was pretty neat.

DrAwdeOccarim 5y ago

But wasn't the whole Pfizer/BioNTech "secret sauce" leaked online after the EMA was hacked?