Duller-Finite

5 ms·

1.
by Duller-Finite 2y ago
That describes a related but previous Nature paper from the same group, whereas this is referring to a more recent Science paper.
2.
by Duller-Finite 2y ago
Yeah seems like related to homeopathic medicine (aromatherapy or essential oils or tinctures)
3.
by Duller-Finite 4y ago
the study said that the 5 patients with VITT that they looked at had the IGLV3-21 * 02 polymorphism, but it's a fallacy to say that means that you can't get clotting without it
4.
by Duller-Finite 4y ago
that study used TALENs; this one used CRISPR base editors
5.
by Duller-Finite 4y ago
It's a shame that Perceptive Automata shut down.
6.
by Duller-Finite 5y ago
Glp and G9a are ubiquitous as they are import epigenetic regulators (histone methyltransferases). Sounds difficult to work on, and hard to supplement if they play an important role in many cell types
7.
by Duller-Finite 5y ago
TRP channels were first cloned over 20 years ago, and are indeed medically relevant for nociception and pain. The piezos are equally relevant; knockouts are embryonically lethal, and the function of mechanosenstation in somatosenation and i
8.
by Duller-Finite 5y ago
As an example, Douglas Bates, the author of R's lme4 excellent package for generalized linear mixed-effects models, has switched to julia to develop MixedModels.jl. The julia version is already excellent, and has many improvements over
9.
by Duller-Finite 5y ago
David Baker's group (author of the RoseTTAFold paper out today in science) has multiple exciting examples of de novo design of proteins. For example, see [1] or [2], and [2] was spun off into a company (Neoleukin Therapeutics). [1] ht
10.
by Duller-Finite 5y ago
This paper is the first structure of any odorant receptor-ligand interaction. There's currently no equivalent structure for mammalian odorant receptors to validate the docking theory, but it's likely correct.
11.
by Duller-Finite 5y ago
Not really. GPCRs amplify signals at each step via their second messenger cascade. These channels form homotetramers whose structure differs greatly from the canonical seven transmembrane domain structure of GPCRs. So this study is importan
12.
by Duller-Finite 5y ago
This is truly a landmark study. This is the first structure of any odorant receptor. It is, however, one from an insect, so the structure is not homologous to mammalian olfactory receptors, which are a large family of G-protein-coupled rece
13.
by Duller-Finite 5y ago
The Code Breaker by Walter Isaacson is a recent biography of Jennifer Doudna, who won the Nobel Prize for her pioneering work on CRISPR, that you might enjoy
14.
by Duller-Finite 5y ago
I don't follow. What's stunning about it? Doesn't it just mean that there is little evolutionary pressure or selection on the olfactory receptor genes? Not sure what the discovery is, or its significance.
15.
by Duller-Finite 5y ago
RNA uses uracil/uridine rather than thymine, but uridine is actually quite immunogenic. That's what has prevented people from using mRNA as a therapy until recently, when the founders of BioNTech figured out that they could use ps
16.
by Duller-Finite 5y ago
lipofectamine is used for in vitro transfection, not in vivo gene delivery. The vaccines use lipid nanoparticles rather than liposomes
17.
by Duller-Finite 6y ago
A similar article was published in Wired about a month ago: https://www.wired.co.uk/article/mrna-coronavirus-vaccine-pfi...
18.
by Duller-Finite 6y ago
I have no idea why you think that there were no studies in April. A quick search shows that's wrong. There were initial reports in March, followed by many peer-reviewed studies that started coming out in April, which were then followed
19.
by Duller-Finite 6y ago
Yes, there were a lot of reports back in March about the loss of smell as a frequent and specific symptom for COVID-19. I'm not sure why this article acts like it's a new thing. And, yes, patients recovering from the loss of smell
20.
by Duller-Finite 6y ago
There were many papers that came out over 4 months ago with more people and other approaches, all with similar conclusion [1-3]. Not sure why this paper is getting a lot of press. [1] https://www.nature.com/articles/s41
21.
by Duller-Finite 6y ago
This is an interesting and well-done paper. It is, however, difficult to evaluate these mouse studies because, unlike human ACE2, mouse ACE2 doesn't facilitate SARS-CoV-2 cell entry. Therefore, they had to first deliver hACE2 either wi
22.
by Duller-Finite 6y ago
While you're right they edited the embryos the sentence you quoted is describing a drug (680C91) that they bath-applied to inhibit the TDO enzyme (as a positive control), rather than the CRISPR strategy they used, in which they injecte
23.
by Duller-Finite 6y ago
The article reports on the in vitro results and says they're going to be doing further validation in vivo. As I mentioned before, the same has been true for basically every other antibody being developed (monoclonals and ones isolated
24.
by Duller-Finite 6y ago
Normally I agree that press releases way oversell the research, but I don't think that was the case here. Their camelid nanobody approach seems to be a fairly novel idea with some nice benefits over traditional antibodies, and most of
25.
by Duller-Finite 6y ago
That's why I'm in favor of this change in nomenclature.
26.
by Duller-Finite 6y ago
Excel isn't the program of choice for most scientists and computational biologists, who typically use R, python, or command line tools. However, we often get data from other scientists or reanalyze data from other groups that can have
27.
by Duller-Finite 6y ago
As a follow-up for those that have said genetic studies have been fruitful, here's excerpts from the most recent genetic study [1]. This study looked at a link in the μ-opioid receptor gene, which was the only gene that barely reached
28.
by Duller-Finite 6y ago
SCN9A variants have certainly been linked to changes in pain sensitivity (in both directions), but where have they been linked to changes in risk for opiate addiction? Even for the variant identified in this paper, the fact that it was link
29.
by Duller-Finite 6y ago
Why are people so keen to look for genetic explanations, rather than socioeconomic ones?
30.
by Duller-Finite 6y ago
Yes, this was noted in the article, which certainly does not proclaim that the CS50 model is the one that all universities and courses should be adopting. "Malan’s contract at Harvard allows him to focus almost exclusively on CS50; eve

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