jinder

6 ms·

1.
by jinder 3y ago
Not just that. In mice, SSRIs stop having any anti-depressant effects if the vagus nerve is severed: https://www.nature.com/articles/s41598-019-50807-8 So they also seem to be effective via the enteric nervous system
2.
by jinder 3y ago
While the serotonin used in your gut doesn’t directly impact the brain, it does impact the enteric nervous system which communicates via the vagus nerve to your brain. So I don’t think it’s correct to say this doesn’t (or couldn’t) impact
3.
by jinder 3y ago
Or perhaps there are significant links demonstrated in murine models of the multi-directional relationship of the gut-brain-immune axis, and that traditional models of disease are not sufficient to elucidate this?
4.
by jinder 3y ago
Where is the best-in-class evidence that CBT is effective at treating long covid and chronic fatigue syndrome?
5.
by jinder 3y ago
Some people really do have mast cell issues, but everyone and their dog thinks they have MCAS these days and it's questionable in my opinion. Often a diagnosis will be based on whether any of the MCAS-drugs work (rather than testing w
6.
by jinder 3y ago
Famotidine an old school H2 antihistamine used for acid reflux (pre PPIs), was found to have an additional mechanism of action via activation of the vagus nerve to inhibit pro-inflammatory cytokines in covid (via alpha 7 nicotinic acetylcho
7.
by jinder 3y ago
What bust are you referring to? As far as I can tell there's still considerable development going on all around London.
8.
by jinder 3y ago
How do Christian contemplative traditions predate Buddhism if Buddhism arose in the 5th century BCE?
9.
by jinder 4y ago
How have you determined that the excess deaths are due to "covid restrictions" and not for example, long term sequelae of covid itself or other factors?
10.
by jinder 4y ago
I think the independent status of the City of London is grossly exaggerated and not really comparable with the Channel Islands.
11.
by jinder 4y ago
And what makes you think that?
12.
by jinder 4y ago
Er no - the loss of a mother is extremely traumatic to a child. It can lead to long term mental health issues and physical health issues.
13.
by jinder 4y ago
To get to the point of re-joining will take a long time with plenty of time for governments and minds in Europe to change. Ultimately the EU is stronger with the UK as a member, and I’m sure if it’s willing to pay a high enough price it wil
14.
by jinder 4y ago
I've used SSP and let's just say I think it's nothing short of revolutionary. It seems to be completely changing how my brain works and how quickly it gets activated (in the sense of what state it is in).
15.
by jinder 4y ago
Try to be born vaginally rather than c-section (might be too late for that!), avoid antibiotics unless you absolutely need them, polyphenol-rich whole food diet with diverse fruits and vegetables, lots of fibre and resistant starch and ferm
16.
by jinder 4y ago
My guess: Environmental toxins, antibiotic use and poor diet leading to loss of microbiome diversity/dysbiosis and consequential disruption to the body’s homeostatic processes.
17.
by jinder 4y ago
GB is not more neutral - it excludes Northern Ireland, which is a part of the UK.
18.
by jinder 4y ago
Yes - totally the opposite. In fact, I think the issue with Angular is that they've not finished the work to make Angular RX-everywhere (for example, reactive components need to be manually plugged into Subjects at the moment). With R
19.
by jinder 4y ago
You're correct - it appears to work via the gut-brain axis, see my comment above.
20.
by jinder 4y ago
To add to my comment, this explains why SSRIs take some time to work - it's the signalling through the vagus nerve that takes time to impact the brain. Other compounds such as curcumin and famotidine (H2 antihsitamine) have also been
21.
by jinder 4y ago
SSRIs appear to work through the vagus nerve in a similar way to psychobiotics. Their direct effects on neurotransmitters are probably an unwanted side-effect: Oral selective serotonin reuptake inhibitors activate vagus nerve dependent gut
22.
by jinder 4y ago
No I don’t think it’s permanent - mine seems to be slowly and progressively improving. You almost have to retrain your autonomic nervous system on a step by step basis.
23.
by jinder 4y ago
It's super super common for people to recover from covid, be okay for a few weeks or even months and then lapse into long covid. In fact, it's relapse-remitting for many people. If you have symptoms of dysautonomia, this can be
24.
by jinder 4y ago
The vast majority of apps you see on the App Store, including most games can be web apps. So I'm not sure what your point is? Apple has deliberately under-invested in implementing web platform features on Safari. If you've tried
25.
by jinder 4y ago
Correct - after years of deliberately hobbling Safari so you couldn't build quality app experiences, they suddenly start releasing lots of useful improvement just as regulators are sniffing around.
26.
by jinder 4y ago
PHGG, GOS and lactulose (if you don't have SIBO) are relatively good prebiotics in my experience. However, the type of prebiotics you use should be tied to what's going on in your microbiome. Some common ones, such as Inulin, ca
27.
by jinder 4y ago
Biomesight is the best 16S provider right now in my opinion. They use Jason Hawrleak reference ranges and interventions as far as I’m aware. However this sort of testing only gives you an overall picture, is pretty variable and works in p
28.
by jinder 5y ago
I'm sure you could - but if you went about it scientifically there would easily be thousands (not just the 3 in Ayurveda). That being said, I do think Ayurveda is mostly about manipulating the microbiome, and I think there are probabl
29.
by jinder 5y ago
I think the reality is closer to different dysbiotic states can cause depression. Depending on the the specific dysbiosis, the interventions will be different.
30.
by jinder 5y ago
Many antidepressants are (e.g. Mirtazapine), but not Sertraline (Zoloft).

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