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While the serotonin used in your gut doesn’t directly impact the brain, it does impact the enteric nervous system which communicates via the vagus nerve to your
by jinder 3y ago
While the serotonin used in your gut doesn’t directly impact the brain, it does impact the enteric nervous system which communicates via the vagus nerve to your brain. So I don’t think it’s correct to say this doesn’t (or couldn’t) impact your mood (and indeed murine experiments demonstrate it does).
- avisser 3y agoPerhaps my favorite science experiment, next to dual-slit, https://radiolab.org/podcast/197242-gut-feelings https://radiolab.org/podcast/197242-gut-feelings They cut the vagus nerves of rats and see behavior change. Which makes sense to me - when "brains" first evolved, the connection to the stomach would've been the prime connection.
- jinder 3y agoNot just that. In mice, SSRIs stop having any anti-depressant effects if the vagus nerve is severed: https://www.nature.com/articles/s41598-019-50807-8 https://www.nature.com/articles/s41598-019-50807-8 So they also seem to be effective via the enteric nervous system!