thenerdhead

8 ms·

1.
by thenerdhead 27d ago
Weird headline. Feels like a distraction from the much more interesting underlying op-ed.
2.
Persistent SARS-CoV-2 RNA and Gut Immune Dysfunction in Long Covid(biorxiv.org)
1 points by thenerdhead 1mo ago|0 comments
3.
Virus reactivation in acute and long Covid-19(nature.com)
10 points by thenerdhead 1mo ago|1 comments
4.
T cells targeting SARS-CoV-2, EBV, and CMV stay in attack mode in Long Covid(cell.com)
5 points by thenerdhead 2mo ago|0 comments
5.
Viral syncytia help SARS-CoV-2 evade interferon and antibodies(nature.com)
3 points by thenerdhead 2mo ago|0 comments
6.
Researchers Detect SARS-CoV-2 Components in Hamsters 365 Days After Infection(biorxiv.org)
2 points by thenerdhead 2mo ago|0 comments
7.
by thenerdhead 2mo ago
Very cool website! That sounds like a good next step, thank you so much!
8.
by thenerdhead 2mo ago
no, vaccines were not available when I got covid and developed long covid months later.
9.
Show HN: TrialPilot – clinical trials from your phone, built by a patient
3 points by thenerdhead 2mo ago|4 comments
10.
by thenerdhead 2mo ago
thats strange as I thought Germany is the one investing over the next decade in these conditions?
11.
by thenerdhead 2mo ago
having posted on this topic for years, your comment is the first I’ve seen come to this rational conclusion. usually people double down on their original perspective
12.
by thenerdhead 2mo ago
strongest evidence so far in gut and immune cells for living organisms. They did find it in the brain of one patient when doing an unrelated procedure at the NIH. That could be due to many things though. General findings around the CSF&#x2F
13.
by thenerdhead 2mo ago
they’ve done 15 days all null and the 25 day one was null but has some unique labs they tested but haven’t posted yet. Paxlovid does something to antiviral genes and shows there’s something there though in secondary analysis (not posted but
14.
by thenerdhead 2mo ago
evidence says yes, but bacteria and other antigens are being studied. ME/CFS shows antigen persistence like long covid has clearly shown. https://www.nature.com/articles/s41467-024-45107-3
15.
by thenerdhead 2mo ago
is a small proof of concept study not a study anymore? gastric biopsies aren’t exactly easy to obtain at scale.
16.
by thenerdhead 2mo ago
they are pretty well understood now with growing evidence of viral persistence in the gut and immune cells, and immune dysfunction causing autoantibodies. they are also distinct from other conditions like ME/CFS or other sequelae altho
17.
by thenerdhead 2mo ago
severity is only one factor in developing long covid. https://www.thelancet.com/journals/laninf/article/PIIS1473-3...
18.
by thenerdhead 2mo ago
not quite. A grab bag of biomarkers being validated in research labs across the USA though
19.
by thenerdhead 2mo ago
small study yes, meaningless no
20.
Autopsy Study Finds Replicating SARS-CoV-2 in the Hearts of Long Covid(my.uscap.org)
134 points by thenerdhead 2mo ago|48 comments
21.
Vagal cholinergic denervation of the gastric mucosa in Long-COVID-19(ijidonline.com)
104 points by thenerdhead 2mo ago|78 comments
22.
Quantification of fibrinaloid clots in plasma from pediatric Long COVID patients(researchsquare.com)
137 points by thenerdhead 11mo ago|136 comments
23.
by thenerdhead 1y ago
what we’re seeing now is that the immune system can go into overdrive, where certain immune cells trigger sepsis-like illness, sometimes in milder or chronic ways. long covid and related conditions seem like part of that same spectrum of im
24.
by thenerdhead 1y ago
Have you heard of Novavax or any of the intranasal vaccines in late trials?
25.
by thenerdhead 1y ago
Yes and those are being funded well. Look at HIV and cancer mRNA breakthroughs. Those aren’t being cut. This is specifically about COVID-19 and flu. Which after 5 years we have better science supporting how to combat them long term. I think
26.
by thenerdhead 1y ago
There are legitimate scientific efforts underway to explore next-gen vaccine platforms like mucosal and T-cell-based strategies. That shift is happening regardless of what RFK Jr. says or doesn’t say. Let’s separate the messenger from the a
27.
by thenerdhead 1y ago
> There has been nothing happening on the common cold virus with MRNA vaccines. In retrospect, it seems like CEOs pumping the stock price with wild promises. So not true. There are numerous candidates for pan-flu and pan-coronavirus vacc
28.
by thenerdhead 1y ago
https://news.ycombinator.com/threads?id=thenerdhead#44805721
29.
by thenerdhead 1y ago
Look, it’s not that BARDA is throwing science out the window in favor of some wishful thinking. It’s that they’re looking beyond what works now and toward what might work better, not just for today’s virus, but for the ones waiting in the w
30.
by thenerdhead 1y ago
It’s tough to get a clear picture, but if you’ve been following the research closely, it’s obvious that there are better long-term candidates in the pipeline. Project Next-Gen is highly data-driven, and the most promising candidates are ris

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