pgcudahy

6 ms·

1.
by pgcudahy 2y ago
This is frustrating that it's marketed as FDA approved but people won't recognize that it is regulated as a medical device, which have to only show safety, rather than as a drug, which have to show safety *and* efficacy .
2.
by pgcudahy 3y ago
OMG, I went down the rabbit hole on this paper and it is bonkers. Their methodology is amateur hour. It's just an uncontrolled non-validated survey sent out by an activist group. What is their list of survey recipients based on? What w
3.
by pgcudahy 3y ago
Not at normal doses. The therapeutic window is narrow, but they're used in millions of animals and we're not seeing an epidemic of seizures. https://www.merckvetmanual.com/toxicology/insecticide-and-ac...
4.
by pgcudahy 3y ago
They target gamma-aminobutyric acid chloride channels (GABACl) that aren't present in mammals. There is a relatively narrow therapeutic index in animals, but generally felt to be safe at approved doses. They're given to millions o
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by pgcudahy 3y ago
"I have not witnessed one machinist harmed by lead in 40 years." Do you know what you're looking for? Lead poising can be subtle but eventually devastating. This is like the asbestos industry saying that miners didn't ge
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by pgcudahy 3y ago
Has anyone tried the new anker or ecoflow lithium portable power stations as a UPS?
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by pgcudahy 3y ago
To get full approval they could combine this with animal efficacy studies like they did for the smallpox treatment tecoviromat, since you can’t give smallpox to trial participants either. https://www.ncbi.nlm.nih.gov/pmc&#x2
8.
Could SpaceX be forced to go public?(old.reddit.com)
2 points by pgcudahy 5y ago|0 comments
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by pgcudahy 5y ago
I've got it running from a Pi3 with no issues serving to multiple roku clients simultaneously. I'm also really happy with how the roku client has gone from just working to well polished in the past year, even on my first gen devic
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by pgcudahy 6y ago
I would think of Henry Ford and the assembly line just prior to this period as the birth of modern manufacturing. Moving from artisans doing most or all of the work on an item to individuals repeating one process repeatedly as the product m
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by pgcudahy 6y ago
There seems to be no analysis of whether these are neutralizing antibodies. The idea of using serology for immunity certificates or "golden tickets" is never going to go well. Even with 99.9% specificity, if the population prevale
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by pgcudahy 7y ago
I think the last elections argue against that https://www.nytimes.com/2020/01/11/world/asia/taiwan-electio...
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by pgcudahy 7y ago
With only 58% sensitivity and 2 false positives for every true positive, this is going to be like the automated drug interaction checks that we all click through because they are too many false positives
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by pgcudahy 7y ago
These articles are posted monthly and I love them. Great in-depth histories.
15.
by pgcudahy 7y ago
In this article and others I've read, people complain about the tidyverse's lack of performance, but I think that places too much emphasis on speed of execution versus speed of development. As an academic, most of the R users I kn
16.
by pgcudahy 8y ago
This article is based on the work of Richard Weller who is trying to monetize them at Relaxsol[relaxsol.com]. I didn't find any disclosure of this in the article. The mainstream view is in a paragraph buried deep: "“I don’t argue
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by pgcudahy 8y ago
This series of longform articles is incredible. The first batch are on the history of the switch and probably add up to a shortish book in length. There's a nice focus on how at several steps there were many who discovered a new innova
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by pgcudahy 10y ago
Looks like it's at stage two in the science hype cycle. http://www.phdcomics.com/comics.php?n=1174 I'll pay attention when a randomized control study shows that supplementing vitamin D lowers rates of autism.
19.
by pgcudahy 10y ago
For biomedical research supported by the US NIH they require it to be posted to PubMed central ( http://www.ncbi.nlm.nih.gov/pmc/ ) within 6 months of publication. Since so many biomedical papers have at least some NIH f
20.
by pgcudahy 11y ago
It won't be catastrophic but it could affect them. Most pacemakers have a mode that if you put a magnet on them they revert to pacing at 60 beats per minute (VVI mode) like a metronome rather than more advanced adaptive modes (like DDD
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by pgcudahy 12y ago
"Its well established that no vaccine has an effect that lasts longer than seven years" Wrong. Every vaccine has a different level of immunigenicity that effects how long it is protective for but some certainly last longer that se
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by pgcudahy 12y ago
Why did Blackstone agree to go through this shady guy rather than just make the deal themselves? What does he bring to the deal?
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by pgcudahy 12y ago
The link is not to Damien's AnkiMobile which is the legit Anki for the iphone ( https://itunes.apple.com/us/app/ankimobile-flashcards/id3734... ) but to some other Anki I've never heard of.
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by pgcudahy 13y ago
These calculators aren't just pulled from thin air, they use studies of various populations over time to derive a mathematical model that predicts the cardiovascular risk of a patient. The article is pretty muddled but it appears that
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by pgcudahy 13y ago
This is pure quackery. The cholesterol -> heart disease framework was developed by the Framingham studies ( http://en.wikipedia.org/wiki/Framingham_Heart_Study ) that showed a strong correlation between cholesterol an