glp1guide

5 ms·

1.
by glp1guide 14d ago
This is a fantastic idea and could do a lot of real good. Any plans to get your hands on a distribution agreement for small molecule or peptide oral formulations? I write a GLP1 newsletter and would love to learn more about what you’re buil
2.
by glp1guide 4mo ago
I keep track of GLP1s and write a lot about them (looking for negative side effects, research results, etc) and it is amazing how potent retatrutide is. It’s not simply a matter of “more agonists, more better” but it looks like Eli Lilly ha
3.
by glp1guide 7mo ago
> I'd love to see more research around this. Looks like we posted around the same time, but see: https://news.ycombinator.com/item?id=46945756
4.
by glp1guide 7mo ago
No one knows of course, but it's looking likely -- anecdotal data is piling up. That said, there are some that have reported it also lessens desire for things they want to desire. Did a writeup on this back in summer '25: https
5.
by glp1guide 8mo ago
Just stating the obvious -- losing weight (and likely lowering HbA1c/having other benefits) for 18 months is probably infinitely better than never losing weight at all.
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by glp1guide 10mo ago
> Of the 308 who benefited from tirzepatide, 254 (82 percent) regained at least 25 percent of the weight they had lost on the drug by week 88. Further, 177 (57 percent) regained at least 50 percent, and 74 (24 percent) regained at least
7.
by glp1guide 10mo ago
Like others have mentioned, liraglutide already exists as a generic! It's not as good as Semaglutide or Tirzepatide, but. Also, a lot of people are still getting compounded GLP1, to the chagrin of Eli Lilly and Novo Nordisk. Separately
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by glp1guide 10mo ago
At this point most experts lean more heavily on the effect of GLP1s in the brain rather than delayed gastric emptying -- it's more of a brain drug than anything else which is why it works so well.
9.
by glp1guide 10mo ago
Basically, the gastro-intestinal side effects are the biggest issue, along with CVS (not the store) and possibly eye problems. That said, the negative side effects look to be incredibly rare and manageable (including via stopping treatment)
10.
by glp1guide 11mo ago
A bit late, but thanks for noting this -- I had no idea that this workaround was so well established. I don't often dive into concrete suggestions on how to obtain GLP1s because of how it could be perceived, but maybe I've underes
11.
by glp1guide 11mo ago
Absolutely -- certainly in their biggest markets they'll be able to protect those patents. Both companies have thus far been unable to really stop compounding pharmacies and/or gray market suppliers from replicating though, and
12.
by glp1guide 11mo ago
Not only that, there is a legitimate raft of companies lining up to make generics. There’s one wrinkle though, legally importing prescription drugs from Canada isn’t really allowed in the US/UK AFAIK. HIMS is probably feverishly figuri
13.
by glp1guide 1y ago
Yeah weirdly enough they’re only taking NAION and gastroparesis cases. Do you know by any chance why that is? The NAION link is tenuous (research was inconclusive, I have written about this before[0]) and gastroparesis is a known side effec
14.
by glp1guide 1y ago
That sounds like a terrible experience, sorry you and the wife went through that and somehow the negative side effects STILL persist. This is honestly the first case I’ve ever heard of such an adverse effect. GLP1s are certainly not for eve
15.
by glp1guide 1y ago
Do yourself a favor, and just take GLP1s instead (after talking to your health care professional). The research on the effects is plentiful, they're incredibly effective, and next year by next year you'll have very effective FDA a
16.
by glp1guide 1y ago
Sorry a bit late here, but the numbers for CagriSema are actually not as good as Retatrutide's were. Unless I'm missing something: Reta 8mg -22% body weight at 48 weeks CagriSema -20.4% body weight at 68 weeks CagriSema has been o
17.
by glp1guide 1y ago
This is a valid concern but the subreddits I'm thinking about are not quite that -- no one is selling or trying to push you to some distributor, it's a lot of the bodybuilding/peptide crowd. More like walking into a classic f
18.
by glp1guide 1y ago
Interesting -- would love to hear anything more you have to share! The research numbers would suggest that Reta was top, results wise. Any other significant differences you felt/noticed? Also, do you find Tirz to be an imiprovement ove
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by glp1guide 1y ago
Well for one they're flying in the face of the patent protection in place for Retatrutide -- that said the legalities around distributing prescription drugs or unknown chemical substances is murky (hence "gray" market).
20.
by glp1guide 1y ago
Well there's no reason, except it's even more effective. And 100%, using Retatrutide right now is illegal/not a good idea. It is super risky. That said, anecdata from people with that risk tolerance is certainly worth looking
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by glp1guide 1y ago
> If Eli Lily is the only producer, how is the gray market being supplied? This makes no sense... It turns out enterprising chemists and pharmacists are capable of reverse engineering. I don't think it's that hard to figure out
22.
by glp1guide 1y ago
It's completely illegal -- the drug is not for sale, obviously is not FDA approved, and is not manufactured anywhere, the only safe/legal way to get it is a via an ongoing trial: https://trials.lilly.com/en-US&#x2F
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by glp1guide 1y ago
I'm incredibly interested -- it's just not legal yet, and the drug is in trials by Eli Lilly: https://trials.lilly.com/en-US/trial/580035 Just to be very explicit here, my profit incentive is selling n
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by glp1guide 1y ago
If you think Ozempic (Semaglutide) is good, Retatrutide is going to blow it out of the water: https://glp1.guide/content/a-new-glp1-retatrutide/ Currently the only people experimenting with it are the underground
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by glp1guide 1y ago
Nope, because the change is actually in the brain . https://glp1.guide/content/research-on-glp1-signaling-in-the... https://glp1.guide/content/research-suggesting-glp1-is-a-bra... https:/&#
26.
by glp1guide 1y ago
Nope! It won't be, because capitalism. In 2026, patent protections that lapse are going to cause a tidal wave: https://glp1.guide/content/novo-nordisk-patent-protections-l... For context, the previous calculus was
27.
by glp1guide 1y ago
> I'm not a fan because it's expensive and once you go off of the drug the weight comes back on (at least from what I've read). That's not a trade-off I want to take lightly. This isn't true https://gl
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by glp1guide 1y ago
We also like to keep track of all the bad ones too[0] (tl;dr they're actually pretty reasonable). It's amazing what lowering inflation, reducing body weight can do to the body. It's almost becoming irrelevant that GLP1 Recept
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by glp1guide 1y ago
Don't worry, GLP1 RAs are nothing like those other drugs. In fact I'd really challenge you to examine even one of the correlations there, the scale of research, use, known side effects, effectiveness is completely different. The i
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by glp1guide 1y ago
I agree with this take but want to add that once everyone is doing it, these opinions will change drastically and everyone will pretend like they were never against it. Another interesting question is where do people go from there? What is

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