5 ms·
No one knows of course, but it's looking likely -- anecdotal data is piling up. That said, there are some that have reported it also lessens desire for things
by glp1guide 7mo ago
No one knows of course, but it's looking likely -- anecdotal data is piling up.
That said, there are some that have reported it also lessens desire for things they want to desire.
Did a writeup on this back in summer '25:
https://glp1guide.substack.com/p/glp1s-vs-addiction-a-quick-review?r=3jmr7l https://glp1guide.substack.com/p/glp1s-vs-addiction-a-quick-...
Paywalled so direct links to notable papers through the years below:
https://pmc.ncbi.nlm.nih.gov/articles/PMC8517504 https://pmc.ncbi.nlm.nih.gov/articles/PMC8517504
https://pmc.ncbi.nlm.nih.gov/articles/PMC8820218 https://pmc.ncbi.nlm.nih.gov/articles/PMC8820218
https://pubmed.ncbi.nlm.nih.gov/36031011 https://pubmed.ncbi.nlm.nih.gov/36031011
https://pmc.ncbi.nlm.nih.gov/articles/PMC10684505 https://pmc.ncbi.nlm.nih.gov/articles/PMC10684505
https://pubmed.ncbi.nlm.nih.gov/39764175 https://pubmed.ncbi.nlm.nih.gov/39764175
https://pubmed.ncbi.nlm.nih.gov/39032839/ https://pubmed.ncbi.nlm.nih.gov/39032839/
https://www.science.org/content/article/obesity-drug-cuts-opiate-craving?ref=glp1.guide https://www.science.org/content/article/obesity-drug-cuts-op...
https://www.statnews.com/2024/02/17/opioid-cravings-glp1-weight-loss-liraglutide-penn-state/?ref=glp1.guide https://www.statnews.com/2024/02/17/opioid-cravings-glp1-wei...
(The science.org article is paywalled IIRC)
https://pubmed.ncbi.nlm.nih.gov/39535805/ https://pubmed.ncbi.nlm.nih.gov/39535805/
https://pubmed.ncbi.nlm.nih.gov/39937469/ https://pubmed.ncbi.nlm.nih.gov/39937469/
Addiction comes up in anecdata all the time so I've written about it a few times but these papers are a good place to start to find more rigorous data points.
Eli Lilly has taken to calling GLP1s "anti-hedonics" as well
- pixl97 7mo agoThis brings up another interesting question. What is the chemical basis of desire in the brain?
- torusle 7mo agoEasy, it is dopamine.
- greygoo222 7mo agoNo it isn't. Every neurotransmitter is involved with every complex phenomenon.