forgotpwagain

11 ms·

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by forgotpwagain 1mo ago
And also their electricity bills rising because of datacenter power demands.
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by forgotpwagain 3mo ago
The Smith chart is the electrical engineer's favorite: https://en.wikipedia.org/wiki/Smith_chart You either love it or hate it, depending on how well your electromagnetics class was taught.
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by forgotpwagain 9mo ago
Unpaywalled: https://archive.is/dmp0m
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by forgotpwagain 1y ago
The cynical part of me wonders: if this has been a promising approach for 10+ years, why weren't they able to secure VC funding years ago (or nonprofit biomedical research funding from places like the Gates Foundation that care a lot a
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by forgotpwagain 1y ago
Thanks for the response! This is very cool and sounds like a reasonable plan. Best of luck!
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by forgotpwagain 1y ago
I am totally onboard with the premise (as a TechBio-adjacent person), and some of the approaches you're taking (focused domain-specific models like Orthrus, rather than massive foundation models like Evo2). I'm curious about what
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by forgotpwagain 1y ago
There are biotech companies like Eikon Therapeutics ( https://www.eikontx.com/ ) where super-resolution microscopy in living cells is a central part of the platform. There is also one widespread approach that isn't ment
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by forgotpwagain 1y ago
A thread from yesterday about why gene therapy hasn't reached its potential: https://news.ycombinator.com/item?id=44573193
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by forgotpwagain 1y ago
DeepMind/Google does a lot more than the other places that most HN readers would think about first (Amazon, Meta, etc). But there is a lot of excellent work with equal ambition and scale happening in pharma and biotech, that is less vi
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by forgotpwagain 1y ago
Very cool. There are also methods that allow you to extract some notion of motion from variability in CryoEM data, e.g. CryoDRGN-ET [1]. I'm curious if you've worked with any of those models and how they relate to NMR data and MD
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by forgotpwagain 1y ago
thought this was about tracing neural circuits in the brain and was disappointed.
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by forgotpwagain 1y ago
Detailed New England Journal of Medicine article about this case: https://www.nejm.org/doi/full/10.1056/NEJMoa2504747 And an Editorial piece (more technical than the NYT): https://www.nejm.org&#x2F
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by forgotpwagain 1y ago
It is possible that they are licensing technology that was developed in academic science and are raising money to scale it up and get it ultra-standarized for commercial scale. I agree that the modern Silicon Valley model of VC funding has
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by forgotpwagain 1y ago
Indeed, now is the moment to step on the gas in biotech. The past 15 years have been nothing short of extraordinary in the field. We finally have the tools needed to effectively measure biology, manipulate biology, and increasingly predict
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by forgotpwagain 1y ago
It is worth mentioning that China is heavily investing in biotechnology and they are getting genuinely good at the more commodified parts of the industry. This blog post [1] is long and aimed at a biotech expert audience, but one summary li
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by forgotpwagain 2y ago
Lots of biotech companies are working on immunosuppressant-free islet-equivalent transplantation. Two examples off the top of my head: Sana recently announced islet cell transplantation without immunosuppression (press release: https:&#x2F
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by forgotpwagain 2y ago
1) Creative projects beget creative projects. When you start working on one project, you'll have ideas for a dozen more, and probably one of those might actually be a good project idea to continue exploring and refining and shaping int
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by forgotpwagain 2y ago
I am pretty sure that the CGP Grey video was the core inspiration for this article. Nearly every image in the article was featured in the YouTube video, which predates the article by ~4 years.
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by forgotpwagain 5y ago
Have you looked into Nebula Genomics? They will do 30X coverage WGS for $299, and will give you the underlying data so you can analyze it on your own (in addition to their analyses). Link: https://nebula.org/whole-genome-seq
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by forgotpwagain 6y ago
Nebula Genomics: https://nebula.org/whole-genome-sequencing/
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by forgotpwagain 6y ago
I would recommend the edX Introduction to Biology course [0]. It is a simplified version of the introductory biology course at MIT, that doesn't _focus_ on naming/defining things in biology. Instead, it uses the lenses of genetics
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by forgotpwagain 6y ago
The Vital Question, by Nick Lane is a pretty good book that takes a thermodynamics first approach to this question.
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by forgotpwagain 7y ago
Mostly agreed. In my eyes, the takeaway from this piece is not that neuroscience is futile and that we should give up, but rather that we now should redouble efforts on analysis methods to make sense of the large, complex datasets that we a
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by forgotpwagain 7y ago
The stories in this piece really highlight the importance of having these tough conversations with family members about what you want to happen for your own medical care if the worst happened. I really enjoyed Being Mortal by Atul Gawande (
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by forgotpwagain 7y ago
On the topic of describing the events of the code (cardiopulmonary resuscitation) in great detail, there have been studies showing that bringing the family into the room during a code leads to decreased PTSD for the family. From a study in
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by forgotpwagain 8y ago
The Allen Institutes are incredible organizations. They do these enormous Big Science projects that no single lab could ever do, generating beautiful datasets that the entire scientific community can use freely. All of their data is publicl
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by forgotpwagain 8y ago
Grape juice is the notorious one here. It doesn't have a very strong taste on its own, so when blended basically serves as a not-technically-added-sugar source of added sugar.
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by forgotpwagain 8y ago
For those who might not know, the University of Edinburgh had a department of artificial intelligence in the 1970s. They were very forward thinking at the time -- it later got folded into the School of Informatics, but Edinburgh remains one
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by forgotpwagain 9y ago
Different kind of tech. Boston is the world's capital of biotech.
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by forgotpwagain 9y ago
Just to add a single word -- I think it is very important that investments be well-targeted. And almost all of the time, this means listening to the scientists involved to get a realistic picture of where the domain experts think the field

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