dmckinno

20 ms·

1.
AI Threatens Our Economy and Democracy Itself(spiegel.de)
3 points by dmckinno 1mo ago|0 comments
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SOTA genome interpretation with agentic AI: Interstitial lung disease case study(gamowlabs.com)
12 points by dmckinno 2mo ago|2 comments
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by dmckinno 3mo ago
OpenAI beat me to the punch in publishing on this, but my results are similar. I hope that these convince you :-) https://openai.com/index/diagnose-rare-childhood-diseases/
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by dmckinno 3mo ago
Sharing this both because it is phenomenal work that will bring peace to 18 families and addresses some of the questions raised when I posted my Gamow Labs founding story last week ( https://news.ycombinator.com/item?id=48471
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Using AI to help physicians diagnose rare genetic diseases affecting children(openai.com)
4 points by dmckinno 3mo ago|1 comments
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by dmckinno 3mo ago
This was short read. I'm in the process of getting my first batch of long reads, but I am skeptical that this is the "just" what's needed. There is little doubt that long read > short read, but I think that computatio
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by dmckinno 3mo ago
Current genomic techniques involve humans using a lot of different software (search, ranking models, visualizations, alignment algorithms, etc.) and synthesizing the results manually into a diagnosis. Your assumption is correct about my tec
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by dmckinno 3mo ago
Thanks for sharing (I am OP). Lots of really interesting computational problems in genetics. The original speech recognition models, HMMs, diffused to genetics ahead of many other fields with which we associate machine learning. Look forwar
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by dmckinno 3mo ago
> Agreed. It does not automatically mean, however, that it can be significantly improved with better variant interpetation or better analysis of the same wgs data in general sense. I wouldn't say anything is automatic or taken for g
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by dmckinno 3mo ago
Opus-4.8/GPT-5.5 coupled with their respective harnesses will do a good job for more vanilla cases, I realized a custom harness and set of skills and MCP servers became essential as complexity increased (mostly hard SVs). I'll get
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by dmckinno 3mo ago
This was not intended to be a technical post (obvious I hope). I'm planning on getting one out in the next few weeks characterizing the system and how it performed on real clinical use-cases vs. alternatives and existing tools. The TL;
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by dmckinno 3mo ago
It's funny you mention Dr. Kingsmore and Rady. While I am truly grateful for him and the team for their contributions to neonatal genetics (and hosting me in San Diego for a few days to show me how I could help), Rady was actually the
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Vibe coding my way to a healthy family: Introducing Gamow Labs(ddmckinnon.com)
215 points by dmckinno 3mo ago|128 comments
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A n00B PM's guide to vibe coding kernels from scratch(ddmckinnon.com)
3 points by dmckinno 6mo ago|0 comments
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by dmckinno 7mo ago
This is kind of like the reverse of the sister comment, which I agree with: https://news.ycombinator.com/item?id=47242699 The general point is that separating PM and eng doesn't make sense any longer. Which subsumes wh
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by dmckinno 7mo ago
I don't remember the exact name, but the one about AI productivity. It should be trivial to find my name from my handle, so just look at my profile.
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by dmckinno 7mo ago
100%. PMs at startups already wear many hats and AI helps them do that even better. But to this sister comment's point, I do think that the dedicated PM role will vanish and the classic BigCo PM will need to look a lot more like the st
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by dmckinno 7mo ago
I totally agree (as a PM of ~10 years). I think that all PMs will need to get onto the engineering, design, or research ladder. We are already seeing companies eliminate the function here and there and I expect the trend to continue.
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by dmckinno 7mo ago
Communicating a feature with a doc or mock can be really hard. A prototype can make things much clearer to a broad audience.
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by dmckinno 7mo ago
Thanks! I posted that one almost a year ago and it blew up on LinkedIn of all places but was totally ignored on HN.
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by dmckinno 7mo ago
You'd be surprised. See this sister comment: https://news.ycombinator.com/item?id=47242372
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by dmckinno 7mo ago
Weird take. Coding is fun (and has been since before AI). And vibe coding is fun in an entirely different way.
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by dmckinno 7mo ago
Funny story: I work at Meta and posted a version of this internally in response the bizarre pressure and support for PMs landing prod diffs (the response was very positive FWIW).
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My spicy take on vibe coding for PMs(ddmckinnon.com)
206 points by dmckinno 7mo ago|192 comments
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Show, Don't Tell: A Llama PM's Guide to Writing GenAI Evals(ddmckinnon.com)
1 points by dmckinno 1y ago|0 comments
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The Dunning-Kruger Effect in LLMs(ddmckinnon.com)
2 points by dmckinno 2y ago|0 comments
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by dmckinno 2y ago
Thanks for the flag. VoiceCraft is indeed the best ZS OSS voice cloning tool, despite appearing at the bottom of the TTS arena They have a really easy-to-use gradio demo on their repo if anyone else wants to give it a try. There is still a
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by dmckinno 2y ago
After spending a bit more time with these models, I wrote up my findings in more detail if anyone is interested in learning more. https://www.ddmckinnon.com/2024/10/03/dans-weekly-ai-speech-...
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by dmckinno 2y ago
This is a bit different. These audio clips use the default voice of each of these systems. I was asking about zero-shot voice cloning, i.e. transferring a recorded voice and synthesizing speech in that voice. I tried zero-shot voice cloning
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Ask HN: What is the state of OSS voice cloning?
12 points by dmckinno 2y ago|5 comments

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