Thebroser

6 ms·

1.
by Thebroser 1y ago
The approach they used which is base editing doesn’t actually insert or remove DNA, it actually uses an enzyme to convert one base to another, which is much safer as this doesn’t require a double strand break in DNA: https://blog
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by Thebroser 1y ago
Add gene has a great guide as to what goes on at the molecular level: https://www.addgene.org/guides/crispr/ Essentially you can design an rna molecular that contains a 20 nucleotide long sequence that can target
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Executive Order on the Safe, Secure, and Trustworthy Development and Use of AI(whitehouse.gov)
4 points by Thebroser 2y ago|0 comments
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by Thebroser 2y ago
I used to love this chrome extension back in the day, unsure if it still works but same idea: https://ottoplay.tv/
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by Thebroser 3y ago
Home lab, or even be able to sequence your genome at home, privately and securely without risking giving your genetic information to companies like 23andme
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by Thebroser 3y ago
There’s also people pursuing mRNA delivery systems to do this. Might be cheaper than viruses and there’s precedent now with COVID vaccines. https://www.capstantx.com/
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by Thebroser 3y ago
There are research groups that are trying to encode genetic neural networks into cells like the example I have attached, but the neuronal approach from the post does seem to be different here. https://www.nature.com/articles
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by Thebroser 3y ago
Would probably assume some level of immunosuppressants might be necessary.
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by Thebroser 4y ago
There are definitely very solid attempts at least to make LLMs that encode biomedical knowledge such as BioGPT which is trained on Pubmed and other domain specific areas. Source: https://arxiv.org/abs/2210.10341
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A universal deep-learning model for zinc finger design(nature.com)
1 points by Thebroser 4y ago|0 comments
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by Thebroser 4y ago
Spatial Transcriptomics. Being able to see gene expression at a resolution of a handful of cells in a cross section of tissue is revolutionizing disease research. https://www.nature.com/articles/s41592-020-01033-y
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Large Language Models Encode Clinical Knowledge(arxiv.org)
2 points by Thebroser 4y ago|0 comments
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PhD students face cash crisis with wages that don’t cover living costs(nature.com)
236 points by Thebroser 4y ago|233 comments
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by Thebroser 4y ago
I am always fascinated by the ignorance that is blatantly displayed on HN when it comes to biotech advancements. Not even some actual criticism of the tech, or even the faint understanding that this sort of thing is exploratory research. Wo
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by Thebroser 4y ago
“Animal research has shown that natural cochlear hair cell regeneration and resultant hearing restoration is very real” - Although exciting, we also need to remember that translatability rates from animal models to humans is notoriously low
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by Thebroser 5y ago
Thanks a ton for your reply! I wish you all the best, tons of cool innovation to be done here.
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by Thebroser 5y ago
Hey! Bioengineering background here, how do you all embed the cells within the scaffold? Is your approach similar to other bioprinting approaches (initial cells seeded via extrusion, inkjet, or laser assisted deposition)? At first I would t
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by Thebroser 5y ago
If you pick up an intro college level bio book that might be enough to start out with. My university publishes this so it would be a nice free start -> https://openstax.org/details/books/biology-2e After that,
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by Thebroser 5y ago
The thing about these developmental conditions is that in theory there a lot of different treatment modalities that can be pursued at the embryonic level that could address these conditions (viral or non viral gene therapy, CRISPR based b
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by Thebroser 5y ago
Yes! The Open Insulin foundation not only has volunteers with a biomedical background, we have volunteers from many other backgrounds including lawyers that help us try and challenge existing patents. Again, others have said that manpower m
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by Thebroser 5y ago
There are crazy patents throughout the entirety of the insulin production pipeline. Some of these being extremely absurd such as patenting the pH of a buffer for specific protocols! I volunteer for the Open Insulin Foundation on/off wh
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by Thebroser 6y ago
Maybe not hard data, but EPIC's software (which is used in about ~25% of hospitals for EHR) has over the years been utilizing patient data to be used for treatment recommendation purposes. Again, difficult to weigh the impact if we don
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by Thebroser 7y ago
http://arep.med.harvard.edu/gmc/genome_services.html Here are some more options! Some usually have holiday deals.
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by Thebroser 7y ago
I tried deleting my account just now and was prompted with a screen asking for it. "Might" might well be an understatement.
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by Thebroser 7y ago
It truly is incredible! The cost of sequencing one's genome is only getting lower (like this company that sequences it for $999 >> https://www.veritasgenetics.com/myGenome ) and the possibilities that this brings