HedonicEscal8r

6 ms·

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by HedonicEscal8r 3d ago
I appreciate the wordplay in the title.
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by HedonicEscal8r 9d ago
As a young person, I have no idea what you guys are talking about, and recommend not overgeneralizing from anecdotes.
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Don't be the Vitamin B guy: towards scientific rigor for decentralized science(hedonicescalator.substack.com)
3 points by HedonicEscal8r 14d ago|0 comments
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by HedonicEscal8r 18d ago
> Anarchist > Name is John Law Makes sense.
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by HedonicEscal8r 20d ago
mRNA vaccines are being studied for pancreatic cancer. To quote a post I wrote in April: > First, the personalized mRNA vaccine autogene cevumeran, developed by BioNTech and Genentech, just reported 6-year follow-up results from their Ph
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by HedonicEscal8r 21d ago
It can be disappointing to see that even a successful drug, like this one, is "only" extending life expectancy from 6.7 months to 13.2. But this is what the first steps towards a cure look like. Childhood leukemia used to be overw
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by HedonicEscal8r 23d ago
The phrase is, "don't get high on your own supply."
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by HedonicEscal8r 24d ago
Tax law is not arbitrarily complicated, and unexpected edge cases are settled by human judges, not by mathematical proofs.
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by HedonicEscal8r 26d ago
This is not quite correct. An mRNA vaccine that creates healthy antigens will fail because it won't do anything, not because it will trigger autoimmune issues. Your cells are already covered in normal antigens, and your immune system a
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by HedonicEscal8r 27d ago
You're confusing me with u/addisonl. Please check usernames before accusing people of trying to "silence the other side." To quote a blog post I wrote on why we can be confident sun exposure causes cancer: "Green et
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by HedonicEscal8r 27d ago
If only this complaint was being posted by an organization ideologically opposed to copyright itself!
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by HedonicEscal8r 27d ago
The piracy organizations are playing 4D chess while everyone else is playing checkers. The irony of this entire situation - AI companies being legally required to shred books due to kafkaesque copyright laws, then used as a marketing tactic
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by HedonicEscal8r 28d ago
u/danjl was originally asking about "this class of drugs", which is more reasonably interpreted as referring to personalized mRNA vaccines rather than the much broader concept of (personalized or not) immunotherapy. The comme
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by HedonicEscal8r 28d ago
Yes, but OP said that in response to a comment attributing melanoma to sun exposure, in a conversation where nobody had brought up SCC or BCC. It's still a misleading comment, in my opinion.
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by HedonicEscal8r 28d ago
One of the leading problems is that we don't know how to pick the right neoantigens (mutant cancer proteins) which can trigger the optimal immune response. Moderna used a simple heuristic, "how likely is this antigen to show up on
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by HedonicEscal8r 28d ago
Interjecting with a fact. Moderna described the neoantigen immunogenicity prediction algorithm they used to design the vaccines as “a deterministic machine learning (ML) algorithm,” so it may be a small neural network or more traditional al
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by HedonicEscal8r 28d ago
Personalized mRNA vaccines are in fact, extremely new, and only made possible by recent advances across multiple fields. This comment reveals a total lack of basic understanding on this topic.
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by HedonicEscal8r 28d ago
Yes, mRNA vaccines are promising for many but not all cancer types, and there are many ongoing clinical trials. There's also a lot we yet don't know about how to design them. Here's a great blog post on this, "How to bui
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by HedonicEscal8r 29d ago
The night sky isn't dark. What you're looking for is cave darkness.
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by HedonicEscal8r 1mo ago
If you think of your screen is a big glowy box of noise that fails to contribute to a good, meaningful life, that's a problem! Put better things on your screen.
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by HedonicEscal8r 1mo ago
"Multiple controlled trials" is quite different from an under-the-table, privately funded bespoke therapy for a single patient.
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by HedonicEscal8r 1mo ago
If the kid's old enough to be hiding their internet history from their parents, they're old enough to have some privacy.
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by HedonicEscal8r 2mo ago
Not that I recommend being on 3-MMC at work, but it's just a matter of dosage. People take pharmaceutical doses of Adderall at work and 10x higher recreational doses at clubs.
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by HedonicEscal8r 2mo ago
The only common drugs that cause deadly withdrawals are alcohol and benzodiazepines. Opioid withdrawals are famously extremely unpleasant but not typically considered life-threatening.
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by HedonicEscal8r 2mo ago
"In experimental studies, the incidence of headache was 50% and the incidence of clinically significant distress or functional impairment was 13%." That is by definition not what "outlier" means.
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by HedonicEscal8r 2mo ago
> Mentioning that they can't actually get pregnant, or impregnate someone, is taboo. Don't know the context, but I don't think this is a "trans" thing. It is usually considered taboo to bring up someone's fe
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by HedonicEscal8r 2mo ago
I agree that you should almost never offer amputations for BIID in minors, since delaying until adulthood would only risk a couple of years of distress and would not cause additional permanent harm.
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by HedonicEscal8r 2mo ago
If you think that a modal person who transitions does so because they don't understand what biological changes can be achieved* and/or because society doesn't accept them "as they are" enough, you are hopelessly con
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by HedonicEscal8r 2mo ago
I disagree with this, puberty blockers should be used sparingly and certainly should not be taken until adulthood. Can you imagine starting puberty at 18? Trans children deserve to mature at the same time as their peers.
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by HedonicEscal8r 2mo ago
If you are 11 and wait 7 years to get a tattoo, your tattoo will look just as good or better. If you are 11 and wait 7 years to transition, you will suffer irreversible physical and psychological damage. You will have missed formative socia

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