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lipofectamine is used for in vitro transfection, not in vivo gene delivery. The vaccines use lipid nanoparticles rather than liposomes
by Duller-Finite 5y ago
lipofectamine is used for in vitro transfection, not in vivo gene delivery. The vaccines use lipid nanoparticles rather than liposomes
- MuffinFlavored 5y agoIf they didn't use lipofectamine, what did they most likely use?
- flobosg 5y agoDerek Lowe discussed it a few months ago: https://blogs.sciencemag.org/pipeline/archives/2021/01/11/rna-vaccines-and-their-lipids https://blogs.sciencemag.org/pipeline/archives/2021/01/11/rn... https://blogs.sciencemag.org/pipeline/archives/2021/02/22/more-on-mrna-vaccine-manufacturing https://blogs.sciencemag.org/pipeline/archives/2021/02/22/mo...
- neuronic 5y agoI absolutely do not have a link, but I remember reading that the lipid nanoparticles are actually created by mechanical action (possibly fluid dynamics/turbulence). I thought that was pretty neat.