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Ozempic and Mounjaro are peptides. They are a silver bullet for obesity and orders of magnitude more effective than anything up to a gastric band surgery. Insul
by zemvpferreira 25d ago
Ozempic and Mounjaro are peptides. They are a silver bullet for obesity and orders of magnitude more effective than anything up to a gastric band surgery. Insulin is a peptide and keeps some 50 million people alive globally. You could go on and on.
The real question is: Should you be putting novel, poorly researched and dubiously manufactured substances (which happen to be peptides) in your body via injection? To that I say, to each their own but I'll wait for the pharma industry to catch up. I'm not that bored.
- mint5 25d agoMy take on the peptides craze is it’s like random people started injected insulin because they have a hazy idea of it being helpful for something or other based on the word on the street but they aren’t sure about dose and also can’t be sure what they’re injecting is actually insulin or uncontaminated. They also aren’t diabetic.
- Legend2440 25d agoMost peptides don't seem nearly as dangerous as insulin, luckily. Injecting insulin without medical supervision is a good way to give yourself hypoglycemia and die - blood sugar regulation is not something you want to mess with! People don't seem to be regularly dying from peptides, at least not now.
- zemvpferreira 24d agoI'd love to be able to make that statement with such confidence, but you just don't know. Literally no one has any clue what the long-term effect of injecting BPC-157 or what ever stupid well-marketed bullshit is the flavour of the week is, is.
- BenzeneDream 24d agoIt is true. Because the short-term effects of incorrectly injecting insulin are far greater and known risks. I agree that the long term effects are unknown but considering you could basically kill yourself quite easily with insulin... its clearly far more dangerous.
- zemvpferreira 23d agoI get the point but given we don't have any rigorous studies on these substances, the only thing we can say with any certainty is that they likely won't kill you now. It's ludicrous of course but we could have a 100% fatality rate over 5 years from a given peptide and we...just wouldn't know at this moment. Don't take insulin if you can avoid it. Don't take other stupid shit if you can avoid it. You can definitely avoid this stupid shit.
- dlenski 24d agoDoesn't this suggest that all these "Chinese peptides" which Silicon Valley people are injecting are probably fake placebos or just ineffectual? If these substances actually had substantial effects on the body, people using them without medical supervision would almost certainly be overdosing with some frequency, I think. (As I understand it, it is very possible to overdose on Ozempic… the reason it doesn't happen is because the purity is controlled, and people are taking specific medically-recommended doses.)
- wpm 24d agoIt doesn't suggest that at all? There are a lot of degrees of impact between "directly affecting blood glucose uptake in cells for respiration" and "nothing burger placebo".
- znpy 24d ago> The real question is: Should you be putting novel, poorly researched and dubiously manufactured substances (which happen to be peptides) in your body via injection? on one hand: no, absolutely not, hell no. on the other hand: these people are voluntarily doing human sperimentation. things like this are going to happen anyway so we might as well collect the data (samples, effect etc). it's not much different from the safe needles initiatives.
- estearum 24d agoExcept the data is completely useless. Especially given the extremely strong selection biases towards: status/image-obsessed; high-risk; low-intelligence; generally high appetite for a constellation of dubious interventions.
- bluefirebrand 24d agoThe data isn't entirely useless. It might be a good signal of areas to point legitimate research toward Narrowing down areas into "Anecdotally many people say it works, we should check" does have some value, even if it does just wind up debunking the claims
- estearum 24d agoIn theory, maybe. In practice, there are far better sources of signal for far more valuable therapeutics to develop. There are far more promising development targets than there is development resources. Self-reports from a bunch of the most drug-addled people in the world are not going to make it to the next-most-viable target.
- Arodex 24d agoSo, chemical pollution and the destruction of our microbiome with excessive antibiotics cause a global obesity problem, and we pump more chemicals into the body to try to solve it. Life out of balance, indeed.
- armchairhacker 24d agoWhat other solution do you propose? (Yes, eating healthy and exercising would probably help most people, but many remain)
- tptacek 24d agoThat's what GLP-1s do: they make it trivial to eat healthily.
- jgalt212 24d agoIf you want to be reductive, and correct, these medicines make it trivial to manage total food intake.
- anon48293 24d agoEating healthy and exercising. And for the remainder: go to your physician to get to a state where you can do healthy diet and exercise. For the small part that remains is highly suggest getting an actual physician to give you treatment options, instead of self medicating with sketchy Chinese chemicals.
- Arodex 24d agoProgress on making fecal transplants more widespread, less wide-spectrum antibiotics prescriptions and more targeted ones (it would help with antibiotics resistance, as a nice side-effect), investing more in bacteriophages as an alternative to antibiotics, and far stronger limits to chemical pollution, and cleaning up existing ones.
- drno123 24d agoBPC-157 was discovered in the late 80s, not really novel. As opposed to mRNA shots that everyone was taking happily.