7 ms·
Combining spicy foods with mint boosts anti-inflammatory effects 100x or more
- josephcsible 5mo agoThat particular combination reminds me of https://www.tumblr.com/nudibranchparty/188803422027/fun-fact-the-nerve-endings-for-ouch-too-hot https://www.tumblr.com/nudibranchparty/188803422027/fun-fact...
- hyperhello 5mo agoCan I take a capsaicin and a mint supplement together? Is that enough to get the effect?
- dylan604 5mo agoIt is funny how that is the thing people turn to rather than just eating food. Let me eat junk and be happy while taking supplements.
- IncreasePosts 5mo agoWhat part of their post indicates they eat junk? Maybe they just don't want to have spicy minty meals every day
- hyperhello 5mo agoI don’t just eat junk, but it’s hard to experiment with a whole dietary change when you have sporadic inflammation. I guess that’s why we do scientific studies, right?
- IncreasePosts 5mo agoSorry to pry, but since you're here, what are the symptoms of sporadic inflammation? Any clues what causes it?
- hyperhello 5mo agoLiterally just getting old. I’m not even old, just not young.
- dlcarrier 5mo agoNormally I'd agree, but in this case I'd opt for the supplement. Spicy mint is a pretty repulsive flavor.
- aappleby 5mo agoNo, the article title is misleading. This is in-vitro research only.
- nosrepa 5mo agoYou'd still get a certain effect when it comes out.
- darth_avocado 5mo agoYou just need Indian food not supplements
- VitalStack 5mo agoThe in-vitro caveat is the key issue here. The "100x" figure refers to inflammatory marker measurements in isolated mouse macrophage cell cultures, a setup where compounds are applied directly to cells at controlled concentrations. Oral supplementation involves digestion, absorption, metabolism, and distribution to tissues that make those in-vitro concentrations essentially unreachable. Taking capsaicin and peppermint supplements together is unlikely to cause harm, but you're not replicating the study conditions. The in-vitro result is interesting as a mechanistic signal. It suggests a possible interaction pathway worth investigating, but it doesn't provide dosing guidance for humans. This gap between study type and real-world applicability is exactly why I built vital-stack.com for supplement interactions in my database, I surface the study type and mechanism alongside the conclusion, so you can judge how much weight to give it.
- ChrisMarshallNY 5mo agoSo ... mint chutney, anyone?
- aappleby 5mo agoThe article title is super misleading - this is about measurements of inflammatory markers in vitro and explicitly does not generalize to food intake.
- mutagen 5mo agoIt is also missing the "in Mice" part of the headline. https://www.mdpi.com/2072-6643/18/3/376 https://www.mdpi.com/2072-6643/18/3/376 Functional Phytochemicals Cooperatively Suppress Inflammation in RAW264.7 Cells RAW 264.7 cells are a mouse macrophage cell line commonly used in research to study immune responses, inflammation, and cancer.
- ngriffiths 5mo agoIn mice, but not even real mice. That's a new one!
- deleted 5mo ago[deleted]
- dlcarrier 5mo agoRelevant xkcd: https://xkcd.com/1217/ https://xkcd.com/1217/
- msuniverse2026 5mo agoPretty interesting. In homeopathy mint is considered one of the most potent antidoting substances which is something that neutralises or cancels the action of another homeopathic remedy. Maybe a comment like this activates chimp brain downvote circuits in HNers but a lot of medicines start from these folk traditions and then make their way into regular medicine.
- krior 5mo agoHomeopathy is not a "folk" tradition, it is simply an insane concept.
- halflife 5mo agoI once sat next to a mint plant and it cured my cold, the farther I sat the better I felt. Obviously diluted mint particles in the air cured me.
- the_real_cher 5mo agoHow was your chakra alignment? That may have contributed to your recovery.
- halflife 5mo agoMy aura turned purple
- the_real_cher 5mo agoThat's great news! I think that means your chakras are in a lotus formation.
- lapetitejort 5mo agoWe must eradicate mint plants. Over time the dilution of mint particles in the air will become so small that all diseases will go extinct
- roughly 5mo agoThis is one of the things that’s deeply challenging for biology and biochemistry - it’s extremely resistant to the sort of reductionism that works so well for other fields. It’s rare to find a single compound, a single species, or a single pathway that’s responsible enough for an effect to show up in studies of the sort of power that one can muster without a ton of time and money, and as soon as you try to capture synergistic effects, you hit a combinatorial wall quickly. In microbiology, for instance, colonies of different bacterial species are the norm, not the exception, and metabolic pathways that span multiple species are common to the point that trying to isolate a given species’ contribution can miss the effect entirely.
- the_real_cher 5mo agoHopefully AI can help us parse some of these massive data sets and interactions.
- Den_VR 5mo ago> metabolic pathways that span multiple species are common to the point that trying to isolate a given species’ contribution can miss the effect entirely. What does this mean?
- 0cf8612b2e1e 5mo agoI think author is saying that you ingest compound A, microbe 1 eats A and secretes B, microbe 2 eats B and releases C. C happens to do <positive thing>. You could imagine parallel pathways where maybe microbe 2 only works if it is in the presence of microbe 3. Meaning everything is a mess to try and disentangle.
- roughly 5mo agoSo, a metabolic pathway is the set of steps by which an organism converts one molecule into another - this can be by splitting a molecule into pieces, by adding or removing an atom or small group of atoms, or by combining two different molecules into a larger or more complex one. By way of a very, very simple pathway, your body breaks down ethanol (alcohol, C2H5OH) by first removing a hydrogen (and causing the oxygen to double-bond to the carbon) to create Acetaldehyde, CH3CH=O, and then oxidizing that by swapping the H remaining on the second carbon for an OH to create Acetic Acid, the primary component in vinegar. So, when we say your body metabolizes ethanol into acetic acid, we're talking about a two step metabolic pathway. Bacteria can stash intermediate pathway results outside of their cell wall for various reasons (sometimes the chemical environment is more amenable outside the cell than inside, sometimes buildup of the intermediates can disrupt other processes, sometimes that's just how it happens - biology is weird), and very often what you'll see is that a multi-step metabolic pathway can span across multiple different organisms - so, species 1 takes up a starting material, performs a handful of modifications, and then excrete the results outside the cell wall, and then another species will take up that substance and perform additional modifications on it, and this can run through several species before reaching the terminal state in the pathway (including the first species again). This works because each bacteria can have different enzymes and different internal chemistry which can affect how easy or likely a reaction is. Nitrogen fixing is a notable example of this - it's not just one species in the roots of legumes responsible for taking N2 and converting it into ammonia, there's 6 or 7 that take part in that pathway.
- jareklupinski 5mo agochase it with a shot of espresso for 1000x increase
- ksjdhdbdb 5mo agoHonestly has anyone tried eating peppermint and chilli?? It honestly amplifies the effects of chilli .... Do not recommend.
- euroderf 5mo agoOTOH chili and coffee together merely destroy your tongue..
- sublinear 5mo agoI think you're far better off looking after your longer term diet to prevent the inflammation in the first place. Antioxidants in plant foods are your phenols, carotenoids, and vitamins while in meat they are amino acids making up complete proteins. The mechanisms at play there are way better understood. I personally try to make sure I include ingredients like garlic, cinnamon, ginger, etc. where possible, guiding my snacks more towards nuts and cheeses, and avoiding too much saturated fat while still getting most of my protein for the day from real meat. I take my salads and stir-fries very seriously, but it seems to be a lost art at times. I try not to overthink these basics, but I'm willing to bet many people have mediocre to poor diets from this perspective despite knowing better because they lose track and things get boring. I feel like in this day and age we should be in the middle of a scientific and culinary renaissance full of exciting recipes that incorporate these ingredients in new ways. Instead I see a lot of traditional or ethnic-inspired cuisine lacking creativity. Not that what we have is bad, just boring. All this to ask if anyone has solid cookbook recommendations?