7 ms·

Nebula and Dante will do this for like $300, and you can get 30x coverage at every base or even 100x coverage if you pay a little more. The $1000 genome was her

by dunk010 11mo ago

Nebula and Dante will do this for like $300, and you can get 30x coverage at every base or even 100x coverage if you pay a little more. The $1000 genome was here more than a decade ago.

sbassi 11mo ago
yes, the difference here is that the $1000 tag is "at-scale price". You reach that price point by running multiple sequencing with a set of reactive.
zaptheimpaler 11mo ago
I wanted to try this, but I looked into Nebula a bit more. Nebula is facing a class action for apparently disclosing detailed genomic data to Meta, Microsoft & Google. The subreddit is also full of reports of people who never received their results years after sending their kits back. There are also concerns about the quality of sequencing and false positives in all DTC genomics testing. Given what happened with 23andme as well and all of this stuff, I'm wary of sending my genetic data to any private company.
- Aurornis 11mo ago
  > There are also concerns about the quality of sequencing and false positives in all DTC genomics testing. Even when the raw results are accurate there is a cottage industry of consultants and snake-oil sellers pushing bad science based on genetic testing results. Outside of a few rare mutations, most people find their genetic testing results underwhelming or hard to interpret. Many of the SNPs come with mild correlations like “1.3X more likely to get this rare condition” which is extremely alarming to people who don’t understand that 1.3 times a very small number is still a very small number. The worst are the consultants and websites that take your files and claim to interpret everything about your life or illness based on a couple SNPs. Usually it’s the famous MTHFR variants, most of which have no actual impact on your life because they’re so common. Yet there are numerous Facebook groups and subreddits telling you to spend $100 on some automated website or consultant who will tell you that your MTHFR and COMT SNPs explain everything about you and your ills, along with which supplements you need to take (through their personal branded supplement web shop or affiliate links, of course).
- phyzome 11mo ago
  Yeah, the only way I would ever do DNA sequencing is anonymously...
  - deleted 11mo ago
    [deleted]
  - jjallen 11mo ago
    Because of public family trees potentially linking a genome to a family, no dna is fully anonymous these days.
    - phyzome 11mo ago
      The DNA itself is not "anonymous", but I would do it without giving my real name, address, etc. They could know who the DNA is related to, but not gain more information than that. Even better would be to swap identity with someone else who wants to get sequenced...
      - ImPostingOnHN 11mo ago
        They would be able to pinpoint your identity (e.g. "this person is the son of both X and Y, and we know who X and Y are").
        phyzome 11mo ago
        And what would that gain them? "X and Y had a son"?
        ImPostingOnHN 11mo ago
        They know who X and Y are, and also know the identity of their son (you), so that gains them your unique DNA sequence, identified as yours specifically.
        phyzome 11mo ago
- mquander 11mo ago
  I was interested to read this because some time ago I had my genome sequenced by Nebula. If you look at the lawsuit you can see that what Nebula did was use off-the-shelf third-party analytics products on their website, including recording analytics pings when users buy a kit, and pings when users use the Nebula website to browse Nebula's high-level analysis of their traits (leaking that the user has those traits to the analytics provider.) This behavior represents a contemptible lack of respect for users' privacy, but it's important to distinguish it from Nebula selling access to users' genomes. https://www.classaction.org/media/portillov-nebula-genomics-inc-et-al.pdf https://www.classaction.org/media/portillov-nebula-genomics-...
  - zaptheimpaler 11mo ago
    That's a good clarification. I read through some of that link, and it does look relatively benign - Meta & Google pixels might see when you buy a kit but nothing more, but on page 21 they directly leaked genetic information to Microsoft via their Clarity tracker. Not intentionally maybe, questionable if it can be linked to a person specifically instead of just an advertising ID but they did leak that. I think the lawsuit says that even disclosing whether a person has undergone genetic testing is in violation of GIPA, so the information they sent to all 3 is enough to violate that. I don't have any evidence they're selling anything but that lawsuit shows pretty sloppy behaviour for a company that should be thinking very deeply about privacy. I guess that's about what you said though :)
  - busterarm 11mo ago
    The point isn't what they are doing with your data now, but that they retain your data and what might happen in the future. Someone with malicious designs on your DNA might buy Nebula tomorrow and there's nothing you can do about it.
    - mquander 11mo ago
      Actually, the main reason I used Nebula was that they advertised a credible-to-me promise that you could download and permanently delete your data upon request. That was some years ago, so I don't know if I would trust them today. But that was their claim, and I have no reason to believe they didn't delete my data.
freehorse 11mo ago
Yeah but then basically somebody else gets ownership of your genetic data and gets the right to do anything with it in the context of their "legitimate interests". Not to mention to probability of that company getting hacked or sold, as it has already happened with some.
subroutine 11mo ago
Does Nebula or Dante provide BAM or just VCF?
- conradev 11mo ago
  Dante includes a BAM
- Metacelsus 11mo ago
  Both do. I got mine through Dante, my wife through Nebula.
sroussey 11mo ago
What about sequencing.com?
otherme123 11mo ago
Note the $2,000 bill includes the DNA extraction machinery and the sequencer itself. The sequencers that Nebula et al use are probably over 1 million $. If you want to go even cheaper and depending of what you want, you can go for an exome instead of a WGS. And a lot of people are sequencing when they really want genotyping. But I would not be surprised if someone is already getting $100 WGS.
stared 11mo ago
I see 399EUR (or $466) for the cheapest variant https://www.dantelabs.com/products/whole-genome-sequencing https://www.dantelabs.com/products/whole-genome-sequencing - or do I miss anything?

by dunk010 11mo ago

Nebula and Dante will do this for like $300, and you can get 30x coverage at every base or even 100x coverage if you pay a little more. The $1000 genome was here more than a decade ago.

sbassi 11mo ago

yes, the difference here is that the $1000 tag is "at-scale price". You reach that price point by running multiple sequencing with a set of reactive.

zaptheimpaler 11mo ago

I wanted to try this, but I looked into Nebula a bit more. Nebula is facing a class action for apparently disclosing detailed genomic data to Meta, Microsoft & Google. The subreddit is also full of reports of people who never received their results years after sending their kits back. There are also concerns about the quality of sequencing and false positives in all DTC genomics testing. Given what happened with 23andme as well and all of this stuff, I'm wary of sending my genetic data to any private company.

Aurornis 11mo ago
> There are also concerns about the quality of sequencing and false positives in all DTC genomics testing. Even when the raw results are accurate there is a cottage industry of consultants and snake-oil sellers pushing bad science based on genetic testing results. Outside of a few rare mutations, most people find their genetic testing results underwhelming or hard to interpret. Many of the SNPs come with mild correlations like “1.3X more likely to get this rare condition” which is extremely alarming to people who don’t understand that 1.3 times a very small number is still a very small number. The worst are the consultants and websites that take your files and claim to interpret everything about your life or illness based on a couple SNPs. Usually it’s the famous MTHFR variants, most of which have no actual impact on your life because they’re so common. Yet there are numerous Facebook groups and subreddits telling you to spend $100 on some automated website or consultant who will tell you that your MTHFR and COMT SNPs explain everything about you and your ills, along with which supplements you need to take (through their personal branded supplement web shop or affiliate links, of course).
phyzome 11mo ago
Yeah, the only way I would ever do DNA sequencing is anonymously...
- deleted 11mo ago
  [deleted]
- jjallen 11mo ago
  Because of public family trees potentially linking a genome to a family, no dna is fully anonymous these days.
  - phyzome 11mo ago
    The DNA itself is not "anonymous", but I would do it without giving my real name, address, etc. They could know who the DNA is related to, but not gain more information than that. Even better would be to swap identity with someone else who wants to get sequenced...
    - ImPostingOnHN 11mo ago
      They would be able to pinpoint your identity (e.g. "this person is the son of both X and Y, and we know who X and Y are").
      - phyzome 11mo ago
        And what would that gain them? "X and Y had a son"?
        ImPostingOnHN 11mo ago
        They know who X and Y are, and also know the identity of their son (you), so that gains them your unique DNA sequence, identified as yours specifically.
        phyzome 11mo ago
mquander 11mo ago
I was interested to read this because some time ago I had my genome sequenced by Nebula. If you look at the lawsuit you can see that what Nebula did was use off-the-shelf third-party analytics products on their website, including recording analytics pings when users buy a kit, and pings when users use the Nebula website to browse Nebula's high-level analysis of their traits (leaking that the user has those traits to the analytics provider.) This behavior represents a contemptible lack of respect for users' privacy, but it's important to distinguish it from Nebula selling access to users' genomes. https://www.classaction.org/media/portillov-nebula-genomics-inc-et-al.pdf https://www.classaction.org/media/portillov-nebula-genomics-...
- zaptheimpaler 11mo ago
  That's a good clarification. I read through some of that link, and it does look relatively benign - Meta & Google pixels might see when you buy a kit but nothing more, but on page 21 they directly leaked genetic information to Microsoft via their Clarity tracker. Not intentionally maybe, questionable if it can be linked to a person specifically instead of just an advertising ID but they did leak that. I think the lawsuit says that even disclosing whether a person has undergone genetic testing is in violation of GIPA, so the information they sent to all 3 is enough to violate that. I don't have any evidence they're selling anything but that lawsuit shows pretty sloppy behaviour for a company that should be thinking very deeply about privacy. I guess that's about what you said though :)
- busterarm 11mo ago
  The point isn't what they are doing with your data now, but that they retain your data and what might happen in the future. Someone with malicious designs on your DNA might buy Nebula tomorrow and there's nothing you can do about it.
  - mquander 11mo ago
    Actually, the main reason I used Nebula was that they advertised a credible-to-me promise that you could download and permanently delete your data upon request. That was some years ago, so I don't know if I would trust them today. But that was their claim, and I have no reason to believe they didn't delete my data.

freehorse 11mo ago

Yeah but then basically somebody else gets ownership of your genetic data and gets the right to do anything with it in the context of their "legitimate interests". Not to mention to probability of that company getting hacked or sold, as it has already happened with some.

subroutine 11mo ago

Does Nebula or Dante provide BAM or just VCF?

conradev 11mo ago
Dante includes a BAM
Metacelsus 11mo ago
Both do. I got mine through Dante, my wife through Nebula.

sroussey 11mo ago

What about sequencing.com?

otherme123 11mo ago

Note the $2,000 bill includes the DNA extraction machinery and the sequencer itself. The sequencers that Nebula et al use are probably over 1 million $. If you want to go even cheaper and depending of what you want, you can go for an exome instead of a WGS. And a lot of people are sequencing when they really want genotyping. But I would not be surprised if someone is already getting $100 WGS.

stared 11mo ago

I see 399EUR (or $466) for the cheapest variant https://www.dantelabs.com/products/whole-genome-sequencing https://www.dantelabs.com/products/whole-genome-sequencing - or do I miss anything?