6 ms·
First randomized trial of Ozempic for alcoholism shows big drops in drinking
- deleted 2y ago[deleted]
- pound 2y agoWould be nice to see the numbers
- comova 2y agoThey will be coming in a few months when it gets published. They showed numbers at the conference but did not want them reported.
- listenallyall 2y agoHonest question, how does one perform a study on "non-treatment seeking participants"? Were these people who signed up and assumed they were part of a weight-loss study but were actually chosen due to drinking habits?
- stevenae 2y agoExclusion Criteria: ... - Current engagement in alcohol treatments, or currently engaged in intentional efforts to quit alcohol use ... ~ https://clinicaltrials.gov/study/NCT05520775 https://clinicaltrials.gov/study/NCT05520775
- listenallyall 2y agoIf one volunteers to participate in a study of a drug suspected to reduce drinking, that itself is a contradiction of the exclusion criteria.
- serf 2y ago>If one volunteers to participate in a study of a drug suspected to reduce drinking, that itself is a contradiction of the exclusion criteria. no, it isn't. many trials offer financial compensation -- they may not be seeking treatment but rather just a payout.
- stevenae 2y agoI'm not disagreeing with that, just stating how they define the term.
- nrdgrrrl 2y agoSeeing the types of things this helps with, I wonder if there is any effect on impulse control issues for people with ADHD in general. Would love to see some studies done on this.
- rwultsch 2y agoI am an overweight person that drank more than I should. Ozempic helped me drop 15 lb and I don’t feel the draw of drink nearly as much as I had. I was diagnosis ADHD as a kid. Since being on Ozempic I have noticed no difference in ability to hold attention.
- mmanfrin 2y agoHaven't noticed any changes in my adhd symptoms.
- choeger 2y agoWill this drug ever stop giving? What does it do next? Stop dementia? Fix short-sightedness?
- deelowe 2y agoWell it's highly addictive for one...
- stevenae 2y agoI haven't seen this reported. Do you have a source?
- black6 2y agoAddictive or not, it's a long-term use pharmaceutical.
- karmajunkie 2y agoHave you got a citation for that? I've not seen anything that indicates the drug itself is addictive, though there's ample evidence that its effects wane quickly after discontinuation of therapy.
- lxe 2y agoSource? It's not habit-forming or addictive from what I'm reading.
- toomuchtodo 2y agoLooking forward to the gene therapy trial results. Going to be crazy ROI on bug fixing the human for this bug. Edit: https://www.fractyl.com/fractyl-health-demonstrates-significant-improvement-in-glucose-control-and-obesity-inpreclinical-studies-of-its-rejuva-glp-1-based-pancreatic-gene-therapy-glp1-pgtxcompared-to-chronic-semaglutide-at/ https://www.fractyl.com/fractyl-health-demonstrates-signific... https://www.remain1study.com/remain-1-study/ https://www.remain1study.com/remain-1-study/
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- bdcravens 2y agoFunny enough I'm an actual diabetic and having the hardest time getting my prescription, from my endocrinologist, filled
- stevenae 2y agoNot suggesting you, or sibling comment, use this, but posting for awareness: https://www.404media.co/people-in-the-philippines-are-calling-us-pharmacies-to-help-americans-find-adderall/ https://www.404media.co/people-in-the-philippines-are-callin...
- aantix 2y agoI'm on Mounjaro, and I've had similar problems with getting it filled. The demand must be insane.
- djtango 2y agoWas on the BBC that now people are buying it from the black market to lose weight for beach bodies
- hnburnsy 2y agoSouth Park just did a whole show on this.
- frodo8sam 2y agoThe problem is also that this class of drugs (modified peptides) is produced in a very different way from most drugs (small molecules). When small molecule GLP-1 receptor agonists hit the market the shortage will be over very quickly. There is a lot of capacity to produce small molecules in place already. Many companies are currently racing to bring small molecules to market.
- disposition2 2y agoI was talking to someone who’s on a similar medication and they were having an equally hard time getting it filled. I wonder if the issues fulfilling the orders of the actual drug product or the overly complex (and highly wasteful) drug delivery mechanism.?
- stuff4ben 2y agoCan confirm! Started Rybelsus (pill form of Ozempic/semaglutide) early last year. Within a month I quit cold turkey on whiskey and other hard liquors at home. Wish I could say the same for wine, but just cutting out the whiskey I was drinking was huge. I'm down ~50lbs since then.
- JohnMakin 2y agoIs it a reduction in cravings, or do you just not feel great if you drink? (like how some other anti drinking meds work)
- stuff4ben 2y agoJust stopped having the cravings for whiskey (and I forgot beer too) at home. I still partake in an old fashioned or a pint of beer when I'm out for dinner and drinks. But for me at home the whiskey was a different "addiction" than wine. I really do wish I could drop the wine, but it just feels different than the whiskey and beer did.
- jaktet 2y agoI’ve been on Zepbound since January and my craving/desire for any alcohol basically is gone. I have gone periods without drinking before while trying to lose weight but I always felt like I was missing out because I was only not drinking to help lose weight, I would avoid some social gatherings just because it wasn’t fun to be there and not “socialize”. Now I just don’t want to and I don’t care about saying no thanks or even think about it. And if I do have a drink it’s usually literally just a drink and even then I might not even finish it. I’m down 60+ lbs so far.
- aantix 2y agoIt's a full feeling. Like after a big meal at Thanksgiving. Where it just wouldn't be comfortable to continue.
- deleted 2y ago[deleted]
- adamgordonbell 2y agoCan someone explain the mechanism of action? Is it working as a generic craving reducer to some extent? So helps with whatever your vice may be? Do the other similar drugs do the same thing?
- bryant 2y agoTen bucks says hunger and reward center actuation are deeply intertwined, and these interesting outcomes of GLP-1 agonists are how we're figuring that out.
- 2c2c 2y agosmoking cessation has been measured as well. i suspect it's generalizable to all forms of addiction, but who knows
- RandomCitizen12 2y agoI can't wait to see it trialed on League of Legends players.
- frodo8sam 2y agoYeah, other GLP-1 receptor agonists are expected to have similar effects. One of the effects of GLP-1 receptor activation is a reduction in the rate of gastric emptying. So it slows down digestion and gives you a full, satiated feeling. Guess the urge for some drugs is related to the urge for food and that's how it supresses drug use. But the last bit is speculation on my part.
- bardak 2y agoI am curious if the benefits for alcohol addiction are from the reduction in appetite or reducing the actual dependence on alcohol. Either way still good to have another relative safe way to treat alcohol addiction.
- mistercheph 2y agoNo way this whole thing will backfire!
- aantix 2y agoGLP-1s have been around for a while. 2005 was the first.
- Bluescreenbuddy 2y agoNovo Nordisk found a money hack.
- deleted 2y ago[deleted]
- jackcosgrove 2y agoAnd if it really is a cure for obesity and alcoholism, we'll all be better off for it.
- aantix 2y ago"Novo Nordisk’s market value of $570 billion is now bigger than the entire Danish economy—creating a ‘Nokia risk’ for Denmark." https://fortune.com/europe/2024/05/01/novo-nordisk-market-value-570-billion-bigger-than-danish-denmark-economy/ https://fortune.com/europe/2024/05/01/novo-nordisk-market-va...
- chadrs 2y agoI'm certainly not qualified to speak on this but I heard this story recently about an effective treatment for alcoholism that's been available for decades but for complicated reasons hasn't been widely accessible: https://www.reflector.show/p/how-to-listen-to-episode-1-the-sea https://www.reflector.show/p/how-to-listen-to-episode-1-the-...
- EdwardDiego 2y agoFor anyone else wondering what the treatment is, it's naltrexone. Saved you a click.
- 4fterd4rk 2y agoThe AA industrial complex has such a hold on this part of our medical system, I doubt you'll see doctors prescribing it to reduce drinking. I was drinking too much, told my doctor, got the usual crap about going to AA. I asked for a naltrexone prescription. He hadn't heard of it, said it wouldn't work, but did give it to me. Alcoholism cured. We already know how to fix it, there's just a lot of people making money off selling the ineffective program from 100 years ago.
- aantix 2y agoIt's important to seek multiple viewpoints. All doctors will have their lenses for which they view problems. Psychological, pharmaceutical, nutritional, etc.
- stuff4ben 2y agoI was lucky in that my doc has been very open to treatments for alcholism and obesity. She prescribed me Nal but it made me very nauseous, worse than Semaglutide. Tried to do the Sinclair Method but just couldn't do it. Then it was the actual diabetic A1C diagnosis that got her to prescribe the Rybelsus. And she was very supportive of me moving to Mounjaro (tirzepitide) when I plateaued in my weight loss.
- tanseydavid 2y ago>> The AA industrial complex has such a hold on this part of our medical system What is the AA industrial complex? I think you are imagining things.
- Kerb_ 2y agoYeah, if you're gonna call AA some sort of nefarious organization it would definitely be a cult, not an industrial complex
- EdwardDiego 2y agoDid you try Disulfiram at all?
- jbandela1 2y agoThis actually makes me a bit concerned about long term, general Ozempic use. This to me at least makes one suspicious that this pathway is very deep in the reward subsystems of the brain, and is not just specific to say appetite and food. What are the long-term effects of Ozempic use on these pathways? I am not sure we know? For example, will people who have taken long-term Ozempic be less likely to do startups because their reward seeking behavior is altered? It will take many years (decades?) before we get a complete picture of all the downstream effects of this. Now, if someone is morbidly obese, severely diabetic, has heart disease, etc, I think it is pretty obvious that the benefits outweigh the risks. However, if it is used as an "easy" way for weight-control, especially long-term, I think there are still questions. If you look back at the history of medicines, we do have a history of "wonder drugs" - see for example Heroin or even the COX-2 inhibitors (Vioxx) that later in retrospect had some major caveats.
- comova 2y agoWe also have a history of vaccines and antibiotics, so I don't think we should automatically assume there's some deep risk. These have been on the market for over a decade now and used by tens of millions of people.
- pertymcpert 2y agoWe know it's generally safe for diabetic people because that's what it was originally for. No one tested long term for the last decade of other potential psychological effects like altered reward seeking behavior.
- rapjr9 2y agoI've wondered about this also. I haven't heard any reporting that mentions whether or not these drugs cause a change in the desire for sex also.
- createaccount99 2y agoMakes me optimistic, sounds like it has potential to be a very effective nootropic, importantly with a lot of research backing it.
- comova 2y agoHi-- this is my article! It's becoming clear that there's a revolution about to happen in addiction treatment through GLP-1s and it might be the first time we get a big positive impact on deaths from alcohol and opioids. Please subscribe to our substack!
- Log_out_ 2y agoWouldnt it be funny if people yelled "moral failures and scoundrels" at a diabetic variant for ages.