zachthewf

7 ms·

1.
by zachthewf 8d ago
Highly recommend the Wired story about Lee: https://www.wired.com/story/lee-holloway-devastating-decline... Long but totally heartbreaking.
2.
by zachthewf 13d ago
I’ve found Sol performance to be incredibly spiky. It has tremendous IQ and can fix very difficult bugs. But it is horrible at design (both visual and system design), anything that involves thinking about users or UX, and massively overcomp
3.
by zachthewf 13d ago
I’d be willing to bet any amount of money that there will be ~the same or more people doing physical labor in 10 years than today.
4.
by zachthewf 14d ago
Looks interesting. What's your plan on the legal front? Bet the company on the compounding lawsuits breaking in your favor, or do you have a backup plan? BTW: when you say you manufacture the drugs, I assume that means you're buyi
5.
by zachthewf 20d ago
Segment had a $3B+ exit to Twilio back in 2020.
6.
by zachthewf 25d ago
Nope, not parody. Very accurate description of early-2020s consumer TTS websites.
7.
by zachthewf 1mo ago
FYI: If you have a company that you are shutting down, you too can sell your data to the labs. Companies will help you do this. If you have a company with a handful of people and you wrote code, collaborated in Slack, and used task manageme
8.
Kalshi will offer prediction markets for clinical trials(bloomberg.com)
6 points by zachthewf 2mo ago|1 comments
9.
Show HN: Beep explicit language in podcasts so you can listen with kids(beepcasts.com)
1 points by zachthewf 3mo ago|0 comments
10.
by zachthewf 3mo ago
I'm open-minded to arguments about AI being a financial bubble and a bad business. I'm not open-minded to arguments about utility, given that I personally witnessed LLMs evolve from interesting but useless toys to insanely helpful
11.
by zachthewf 3mo ago
I didn't read the posted article (I don't read this author anymore because I think it's basically anti-AI ideological propaganda). But from the article I linked back in March 2024: "Generative AI models are expensive and
12.
by zachthewf 3mo ago
Before you spend 20 minutes reading this article, it's worth understanding that the writer has been posting popular but consistently wrong takes for 2+ years (e.g. https://www.wheresyoured.at/peakai/ from March 20
13.
by zachthewf 3mo ago
Biohub is funded by Zuck and his wife - the full name is "Chan Zuckerberg Biohub" https://en.wikipedia.org/wiki/Chan_Zuckerberg_Biohub
14.
by zachthewf 8mo ago
or maybe the nutrition guidelines just don't matter that much.
15.
by zachthewf 8mo ago
I like the look and brand, but the animations/clickjacking are really jerky for me. Are you not having any issues with that?
16.
by zachthewf 10mo ago
Decamillionaires complaining about billionaires. A story as old as time...
17.
BoltzGen – design protein binders with Boltz(github.com)
1 points by zachthewf 11mo ago|0 comments
18.
by zachthewf 1y ago
No it’s a diffusion model trained on proteins
19.
by zachthewf 1y ago
It’s not that simple. Even if you take the cynical view that the company is your adversary, the other people who work at the company (including founders, investors and execs) are actually playing a career-long collaborative game rather than
20.
by zachthewf 1y ago
They crossed the hurdle once but are less willing to do so repeatedly (so they churn)
21.
by zachthewf 1y ago
Maybe. FWIW the majority of the apps that have taken off are basically AI girlfriends/AI boyfriends. Using these is fundamentally a shameful act which probably deflates retention. There may be high retention use cases that find ways to
22.
by zachthewf 1y ago
We know they don't work at OpenAI or Anthropic, but beyond that have no information
23.
by zachthewf 1y ago
Sonnet is noticeably worse in my opinion. It’s worth it to spring for Max and only use Opus
24.
by zachthewf 1y ago
Probably glasses or airpods.
25.
by zachthewf 1y ago
There are certainly slow-moving ecommerce platforms that I'm sure would be happy to take your business. Yet Shopify has the best product. Why do you think that is?
26.
by zachthewf 1y ago
The argument is that vibe coding is great for little personal programs but bad for full-blown products. I don't think you can ship a fully baked product made exclusively with AI coding yet. But it's *really* useful for investigati
27.
by zachthewf 2y ago
If you're an accredited investor (make sure you meet the financial criteria) you can cold email seed/pre-seed stage companies. These companies typically raise on SAFEs and may have low minimum investments (say $5k or $10k). YC lis
28.
by zachthewf 2y ago
And often when YC invests in multiple companies in a space there are multiple winners: - Gusto, Rippling, and Deel - Mixpanel, Amplitude, Posthog
29.
by zachthewf 2y ago
Congrats on the launch!
30.
by zachthewf 2y ago
He went to Yale and worked at a prestigious VC firm. Most people with those credentials are at least reasonably smart.

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