wittyreference

8 ms·

91.
by wittyreference 6y ago
Several classes of opioids have been shown to cause neuronal degeneration via ATF4 activation. So, key points: 1. Loperamide is not unique. I don't know why these researchers have singled it out. Is it because they heard there's a
92.
by wittyreference 6y ago
My ISP has already replaced it with a “wifi access charge.” Because the router they provide has WiFi capability.
93.
by wittyreference 6y ago
Do you think that working out entirely alone vs. with a trainer is the same thing? Do you think there are some people that would derive a differential benefit by going with one vs. the other? Do you think that working out entirely alone vs.
94.
by wittyreference 6y ago
Not if you already have a tablet or smartphone. Which, you know... probably most people in the "looking for an indoor cycling bike" market do. Never mind that even if they didn't, purchasing an ipad that you occasionally stic
95.
by wittyreference 6y ago
A cadence sensor and an ipad holder.
96.
by wittyreference 6y ago
I don't know about what the Peloton experience is like, but: My bike is on a trainer, and I see the following down-sides: a) My bike on a trainer is really loud. Can't do it early; can't do it when the baby is sleeping, etc.
97.
by wittyreference 6y ago
There are emergencies, and there are EMERGENCIES. The former can often wait 24 hours; the latter cannot wait at all. Medicare data does not capture that at all - it only captures the categorical, "surgery type." e.g., someone has
98.
by wittyreference 6y ago
Poking my head in as a physician that is also frustrated with some of the reporting on this topic, it's worth noting that a lot of the reporting seems earnest, but loses context when the person translating 'expert talk' into
99.
by wittyreference 6y ago
If a business can't run profitably and legally at scale, then that business model is a bad fit for that scale and shouldn't exist at that scale (presuming the laws in question are reasonable, which I think 'banning child porn
100.
by wittyreference 6y ago
I don't think it's unreasonable that the stances that most regularly get highly upvoted to the top of the threads are taken as a gestalt 'HN opinion'.
101.
by wittyreference 6y ago
> It was not uncommon to see apartments with open windows in January to help regulate the heat produced by the radiator. Known as the Brooklyn Thermostat.
102.
by wittyreference 6y ago
As my Siberian parents taught me growing up: There's no such thing as bad weather; there's just being incorrectly dressed for it.
103.
by wittyreference 6y ago
That's not what phase 1 is for. Phase 1 is essentially to test "will this drug cause terrible harm to people who receive it in a reasonably short time frame?" In terms of dosage guidelines, phase 1 studies often don't ha
104.
by wittyreference 6y ago
I'm a physician in a hospital that has literally entire floor units - plural - occupied by nothing but dyspnea, a respiratory step-down unit that has become an expansion of the ICU, residents pulled off of every non-internal medicine
105.
by wittyreference 6y ago
Not particularly - I last read about them when I was a bio undergrad, and they weren't brand new then. The key words I'd use in google scholar are 'adenovirus vector mRNA', but be sure to restrict the timeline to pre-202
106.
by wittyreference 6y ago
The vaccine in this instance is all about delivering a target to the immune system's sentries. If those sentries are defective, or if the hitmen the sentries need to alert are defective, there's nothing this vaccine can do to chan
107.
by wittyreference 6y ago
I'll add a point, because otherwise your answer was excellent: This mechanism was once explored as a means of performing gene therapy in human beings (a couple of decades past). It was abandoned because of its utter failure to produce
108.
by wittyreference 6y ago
You make it sound foolish and shallow, but I think it's quite reasonable that the venn diagram has overlap in the middle. These platforms quite intentionally assumed two contradictory roles: that of editor, and that of public square. W
109.
by wittyreference 6y ago
My Bose QC35 are now seven years old or so, and they still charge up fast and hold it for a good long while. I don't know if they're as good as new, but they're close enough that I can't tell the difference. I don't
110.
by wittyreference 6y ago
You say that as though having a patent in Country X protects you from IP theft by country Y. When the bad actors and the good-faith actors participate in the same market, and regulations protect good-faith actors only in a submarket, ... uh
111.
by wittyreference 6y ago
In anything with a cyclical component, being right "too early" and being wrong are very nearly the same thing, and certainly close enough as to make no difference. Do you have an overview of his trading history that suggests he&#x
112.
by wittyreference 6y ago
1) For a PCP that does ear cleanings, you could have done that for peanuts. I used to know an FM guy who would do it regularly for patients (maybe a touch too regularly). 2) Heh, it's actually a standard board exam question about &quot
113.
by wittyreference 6y ago
I've never been able to develop and intuitive understanding of what sort of phenomenon should obey a Pareto distribution, as opposed to a normal or logarithmic one (which I do feel I understand.) Any nuggets of insight here on HN?
114.
by wittyreference 6y ago
I’m confused. What’s to stop these orgs from shuttling all their lower paid employees into a distinct staffing solutions LLC and just use them to “hire” staff for a parent company comprised of executives? Other fields do this regularly - ho
115.
by wittyreference 6y ago
When you see the writers are all osteopaths, it tells you all you need to know.
116.
by wittyreference 6y ago
> I'm pretty confident that most of the services he is complaining about will last longer than his own blog post. And yet years of fantastic RPG community contributions on g+ are absolutely fucking gone. At their best they got taken
117.
by wittyreference 6y ago
Even after they got busted, I had their sells reps pitching my organization that they have proper E2E encryption, and that the public claims were mistaken. So, no. This perfectly above-board version is not what happened.
118.
by wittyreference 6y ago
I have a hard time picturing a situation where that would be better than a similarly armed drone.
119.
by wittyreference 6y ago
Physician income and drug prices are entirely unrelated, except for the oncologists whose salary derives from reselling onco drugs. That you think they are somehow related strongly undermines the rest of your post, as it suggests you are ve
120.
by wittyreference 6y ago
>so much so that I find it odd to be calling MIT out in particular. Because the author is relaying their personal experiences as a student at MIT.

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