wittyreference

8 ms·

61.
by wittyreference 6y ago
It's probably not meaningfully higher - this discovery was made a long time ago, and since then we've had a lot of research into which tumors it's really relevant to, and those tumors now get anti-inflammatory medication as a
62.
by wittyreference 6y ago
Okay, that's what I get for trying to be even slightly witty, username notwithstanding. Some cells never divide, and so theoretically shouldn't become cancerous. They still happen though: myocardium tumors shouldn't happen, b
63.
by wittyreference 6y ago
Nah, it just means that: (a) True cancer cures will be more dynamic than cutting bits off, like very sophisticated immune therapies, or (b) We'll get really good at replacing cut off bits.
64.
by wittyreference 6y ago
(5) Tissue Invasion. Solid cells generally sit on a foundation called basement membrane. Tissue invasion means "fuck basement membrane, I'm cutting through it and getting into the sewer pipes (blood vessels) below!" This actu
65.
by wittyreference 6y ago
Sure! So, this is just a conceptual schema, and not a hard-and-fast rule. It was first published by Robert A. Weinberg in 2000 as "the six hallmarks of cancer", as an attempt to distill down everything we knew about cancer genesis
66.
by wittyreference 6y ago
A little bit? You've got it essentially correct, it's just that every metabolic pathway is in a dynamic equilibrium. So let's say you do deprive the body of fresh glucose intake. While liver is turning fat into ketone bodies,
67.
by wittyreference 6y ago
I do wish people were more aware of how common pre-cancer cells are. Generally speaking, there are about eight major functional changes in the cell needed to go from 'cell' to 'cancer cell', and on average, each takes ab
68.
by wittyreference 6y ago
Chlorine sucks. It's added to water because the other major way of disinfecting water (ozone) is too transient to last all the way through the water pipelines. Nonetheless, they're often used in combination, to minimize the amount
69.
by wittyreference 6y ago
Great questions. 1. We do attempt to attack cancers by reducing their available energy. That's why, at one point, a major field of research in cancer therapeutics was interfering with angiogenesis, because cancers will secrete messenge
70.
by wittyreference 6y ago
> There is a relatively new theory saying that malignant, metastatic cancer cells behave like single cell organisms, and that cancer basically represents an unwanted return to our genetic roots It's not close to even 'relati
71.
by wittyreference 6y ago
I can say that I would, because I was in your place, and I did reach out - even though it took me a long time to do so, which brought me far closer to the precipice than I'd care to dwell on. I can't say that I did it without trep
72.
by wittyreference 6y ago
Yes. The featured article notes that they were providing links on their Twitter account. Their quoted defense includes, to paraphrase, the account was /mostly/ discussing open access issues, it wasn’t /primarily/ for sha
73.
by wittyreference 6y ago
I kind of feel obligated to pipe in as a physician: There are signs of people not being a high suicide risk, despite depression and overt claims of suicidality. This post is the absolute opposite of that - if you were with me in the clinic
74.
by wittyreference 6y ago
I came up with the same idea for treating autoimmune disease years ago - in my first year of med school, actually. Back then the platform for doing this elegantly via mRNA didn't really exist, though, and I didn't want to drop out
75.
by wittyreference 6y ago
Actually signing a contract doesn't begin and end at a signature. It requires a meeting of the minds, which the signature is meant to represent. A contract without a meeting of the minds - such as a contract presented in a context coer
76.
by wittyreference 6y ago
Can't wait to find some non-evil, non-corrupt politicians. Is there a Yelp for finding those?
77.
by wittyreference 6y ago
I think a relevant point is that UPenn has been publicizing their past affiliation with her and her research, in order to bask in some reflected glory for developing the vaccine technology. If not for that, it would indeed be decades-old eg
78.
by wittyreference 6y ago
Cocaine is also used as a medication. We use topical spray cocaine for anesthetizing the nasal cavity and pharynx before certain procedures. Just saying.
79.
by wittyreference 6y ago
Double jeopardy applies to criminal prosecution by the state, not civil matters between non-state entities.
80.
by wittyreference 6y ago
https://scholar.google.com/scholar?hl=en&as_sdt=0%2C33&q=alc... There's a lot to go through.
81.
by wittyreference 6y ago
So, my interest in these drugs is primarily from a therapeutic standpoint, so those without therapeutic effects are less within my wheelhouse. My ignorance caveated, I'll say with a grain of salt: 1. We have a shitty understanding of c
82.
by wittyreference 6y ago
I'm a big fan of Stahl's Psychopharmacology. Since pretty much every illicit drug has a legal equivalent, but the legals are better studied, you'll probably find that a good source. If your primary interest is illicit drugs,
83.
by wittyreference 6y ago
Challenge away, it's the internet! I think that it's possible but unlikely that loperamide is having a unique effect, because (a) they've shown that it's operating via the ATF4 mechanism, which is the same mechanism we s
84.
by wittyreference 6y ago
I haven't heard of morphine being generally cardioprotective, but I'm no cardiologist. It's routinely given during heart attacks because it reduces cardiac demand, so it reduces the heart tissue that dies due to lack of oxy
85.
by wittyreference 6y ago
Opioids have already been studied regarding their neurotoxic effect. We already know they are neurotoxic. We already know they use the ATF4 pathway. Loperamide is an opioid. It's like a study finding that "opioid X" gets you
86.
by wittyreference 6y ago
I have lots of interests outside of medicine, including programming (and bookbinding, archery, powerlifting, and etc.) I got to HN itself ... I don't know how. I delete my account about once a year to try and limit my breadcrumb trail,
87.
by wittyreference 6y ago
That's an excellent question, and an area of active research. It differs a lot by drug, though, because of their affect on different signaling systems, different neurons, and due to indirect damage to the brain from effects elsewhere i
88.
by wittyreference 6y ago
True. The blood-brain barrier is a relative barrier, not an absolute one. When we say it doesn't have (effect X), we mean "within the normal range of doses."
89.
by wittyreference 6y ago
Medical doctor.
90.
by wittyreference 6y ago
I don't know if chronic opioid exposure drives other cells to death. It certainly does cause some neuronal death, which we've already established with other opioids, also using the ATF4 mechanism. The tumor in this paper is a brai

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