vibrio

5 ms·

1.
by vibrio 8d ago
What are their data privacy and security policies? That is an important consideration.
2.
by vibrio 1mo ago
…and a trusted doctor isn’t necessarily a replacement for the CDC.
3.
by vibrio 1mo ago
Nice work! Love it.
4.
by vibrio 2mo ago
Wtf world do we live in that this sentence exists.
5.
by vibrio 2mo ago
To add a somewhat cynical view, a significant part of the original motivation for the ranibizumab (Lucentis) development was due to pricing arbitrage across diseases. bevicizumab was priced based on uses in cancer indications with a “large
6.
by vibrio 2mo ago
I agree with you that AAV is clearly a useful tool but at times the low levels of self discipline and scientific rigor that the field has applied to dosing is disappointing at best and scary at times. This includes use of other vector types
7.
by vibrio 2mo ago
I suspect there is a deep sequencing service that is non CLIA and cheap. True. they may not be trustworthy with the data. That said, there are steps here where the data is put into Claude. Do we trust that ?
8.
by vibrio 4mo ago
Maybe also an interesting case study in the inconsistent application of copyright law.
9.
by vibrio 4mo ago
I think their point is not the ESG component, but firms with traditionally irrational valuations (à la GameStop) for which index inclusion exceptions have been made to facilitate short term liquidity for IPO participants. Seems as though o
10.
by vibrio 4mo ago
I can’t wait until Thanksgiving.
11.
by vibrio 5mo ago
Just in that it’s not gonna work.
12.
by vibrio 6mo ago
…Better plan all day Better plan all week, better plan all month, better plan all year…. (Sorry, esoteric song lyric that applies.)
13.
by vibrio 7mo ago
Interesting analogy.
14.
by vibrio 7mo ago
This is interesting. As a naive user I’ve gotten the gut feeling of commoditization among the models. I assumed the data center capacity push is intended to be the differentiator but that still seems utility-like over time. (and the data
15.
by vibrio 7mo ago
(not intending ot be snarky, but this isn't my area of knowledge in the least.) Didn't the AI organizations 'get it both ways' when they trained on vast collection of works under copyright and then purely "own&#x27
16.
by vibrio 7mo ago
You've succinctly identified and communicated a real problem. In your opinion, what is the best approach, if any, to attempt to address it?
17.
by vibrio 8mo ago
Put this way, this seems reasonable. Beyond cell therapy, I don't thin the cost of drug is the motivation for not making it more freely available. 'Misuse' leading to potential liability or unjustified bad outcomes, along wi
18.
by vibrio 8mo ago
So charging patients/insurance companies at cost to fund the clinical studies?
19.
by vibrio 8mo ago
Not even cost plus? Not sure how that works, from the viewpoint of economic incentives.
20.
by vibrio 8mo ago
Knowing whether drugs work isn’t trivial. Patients are typically very heterogeneous in their responses to drugs. For example, pembrolizumab (the most successful cancer drug ever) typically only works in, say 30% of patients depending of th
21.
by vibrio 8mo ago
Cane you provide a list of the “stupid” drug approvals?
22.
by vibrio 8mo ago
lol. The battery life seems so short, I was starting to wonder whether this was the case...
23.
by vibrio 8mo ago
Slightly different point but many bacteria in us right now also make lipopolysaccharide (LPS). If it were purified and injected iv, the LPS in me could probably kill me 1000 x over.
24.
by vibrio 9mo ago
I agreee with the caution. I am not endocrinologist enough to guess what may happen and when. Because of the level of variably in all that is being experimented with, my guess is there may be a slower burn rather than explosion of odd toxic
25.
by vibrio 9mo ago
Will side effects for hormonal and gene therapy approaches be shaken out in just 3-5 years? For gene therapy, the rare blood cancers associated with car-t or bluebirdbio suggest maybe not. Maybe they remain rare, but as scale and flexibilit
26.
by vibrio 9mo ago
“Viruses” have a very broad feature set-beyond evoking Batman, it seems like a lot of details need to be hammered out here, even residually chlorinated water can be problematic in maintaining titers. IMO, These days, public health policy (
27.
by vibrio 9mo ago
AIDS has been treatable for a few decades, with good progression getting it to developing world and some towards a cure. That said, some of this recent progress has been impeded due to differing beliefs of some current governmental regul
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by vibrio 9mo ago
This made me think of the "Institute for one world health" . It came out as a non-profit pharmaceutical company in the mid 2000's. Victoria Hale was the founder-it got her a MacArthur fellowship. It is focuses(focused?) on g
29.
by vibrio 9mo ago
also, Elephants have a much higher copy number of a gene called p53/ It codes a protein that acts to force suicide in cells that have damaged DNA (think from UV light, cigarette smoke, age, etc). In cancer this is a common 'early
30.
by vibrio 10mo ago
As a bit of a Flight Aware addict, well done.

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