snystrom

5 ms·

1.
by snystrom 5y ago
> 'adult cell' (which I'd assume analogous to differentiated cell) That's correct. > I'd guess the transfer process is why she arrived with shorter telomeres at birth? Also spot on. The donor somatic cell like
2.
by snystrom 5y ago
For some extra context, Dolly was not made using the iPSC approach (reversing differentiation from adult cells). Dolly was cloned using a process called Somatic Cell Nuclear Transfer, where the nucleus of an adult cell is placed inside an e
3.
by snystrom 5y ago
There has been a significant amount of work in this area. One of the most notable breakthroughs was from Shinya Yamanaka (and his lab) in 2006 & onward where they defined a core set of factors that can be expressed in adult cells to con
4.
by snystrom 5y ago
You totally should, it's a lot of fun. I'd suggest trying to find some bacterial genome sequencing (like E. coli) done on nanopore if you're interested in those data. I don't have a link to any handy right now, otherwise
5.
by snystrom 5y ago
Tl;Dr: Nanopore data is historically lower quality than current gold-standard methods, but it is by no means "not viable" in a genomics pipeline. Their newer chemistry flowcells are competitive with current gold-standard (but I&#x
6.
by snystrom 5y ago
I have literally no skin in the game here, but here's another interesting group that totally bailed on a similar project because I guess they hated Julia so much. Good to see something else crop up. github.com/JuliaOptics/Abo
7.
by snystrom 6y ago
You're correct that there's never been an experiment on the scale of the current pandemic, but there is a long history of demonstrating that viruses rapidly evolve to escape antibodies, and that this effect is enhanced under direc
8.
by snystrom 6y ago
A strong argument against this is the potential to apply selective pressure for virus variants that escape antibody binding. After the first vaccine dose, antibody titer in the blood is lower than it would be after 2 doses. Some of the new