sdbrown

5 ms·

1.
by sdbrown 8mo ago
On a related-different axis, I've consistently seen on-prem GPUs running identical workloads ~35% faster than the same workloads on the same cloud hardware, regardless of intermediate infra stack layering/versioning choices. Weird
2.
by sdbrown 2y ago
Wasn't this part of the base thesis of "We Have Never Been Modern"?
3.
by sdbrown 2y ago
Are you referring to Bruno Latour or the author of the post? If you're referring to Latour, I would strongly urge you to read "Laboratory Life", which is [as] clear and easy to read today as it was when I first encountered it
4.
by sdbrown 3y ago
I don't see dilution anywhere on that page, and increasing volume of administration at a lower concentration to achieve the same effective dose does not alter the dose itself. You are not interpreting TI correctly. Edit: further, to yo
5.
by sdbrown 3y ago
That doesn't change the difference between effective and toxic doses, it changes the potential scale of off-by-one user error. If 20 milligrams is delivered in 1 tablet, then 3 tablets is the toxic dose. If 20 milligrams is delivered i
6.
by sdbrown 3y ago
Tadalafil (Cialis) is available as a generic in the United States. If you think "big pharma" is served by drugs going off-patent, you may want to re-evaluate your perspective. If you want to get more reasonably unhappy with market
7.
by sdbrown 3y ago
How, in your view, does dilution change the therapeutic index of a chemical? If a drug is effective at 20 milligrams, but at 60 milligrams has a steep rise in the incidence of hypotension, how does taking that same 60 milligrams in a larger
8.
by sdbrown 3y ago
To me it sounds dialed-in even on immediate landing. Different strokes!
9.
by sdbrown 4y ago
Apologies -- tetrazine reacts principally with trans-cyclooctenes. So azide/DBCO would be the orthogonal group. To the best of my knowledge, those two pairs do not cross-react.
10.
by sdbrown 4y ago
Tetrazine/DBCO is also pretty popular IIRC.
11.
by sdbrown 4y ago
Huh! https://biomedical-engineering-online.biomedcentral.com/arti...
12.
by sdbrown 4y ago
I feel like fingerprint/iris/retinal scanners would be a reasonable stop-gap here if only there was some way to deploy them cheaply. Does anyone know if such add-ons exist that might be made compatible with a 2FA system?
13.
by sdbrown 5y ago
This is a fabulous convenience! The reach of this ready-to-go data will be much larger (in some directions) than the model and CASP results themselves.
14.
by sdbrown 5y ago
See figure 3: https://onlinelibrary.wiley.com/doi/10.1002/advs.202100564 Doesn't the measurement of current in the presence of light mean photo-voltaic?
15.
by sdbrown 5y ago
I appreciate your comment; medication saved me from tanking what has been a relatively successful career. However, they bring up a reasonable question, which is that of conflicts-of-interest. I do not now, nor have a I ever, received any co
16.
by sdbrown 5y ago
Literally LOL! My meds have been generic for so long that the most regular non-appointment-reminder phone calls I get are the pharmacy telling me that the manufacturer and appearance of the pills has changed.
17.
by sdbrown 5y ago
This was the biggest benefit for me.
18.
by sdbrown 5y ago
It's been about 9 years and I'm still on the original dose of the first medication my psychiatrist prescribed. I'm really glad I managed my pride enough to make that first appointment. - Slept better. No more tossing and turn
19.
by sdbrown 6y ago
I hadn't thought about that before! Very slick incentive structure there...like, build the tech to go to space and mine it and become enormously wealthy on Earth (ignoring the amount of wealth required to accomplish this).
20.
by sdbrown 6y ago
A k-D tree?
21.
by sdbrown 6y ago
My partner is a physician, and this is _exactly_ how they manage disagreements about treatment plans, almost by instinct. It is amazing how well this works at clearing things up.
22.
by sdbrown 6y ago
Or, can it (like humans?) adapt its responses to suit the style of the question? Like if you start asking it lots of antagonizing questions, will it become more or less antagonistic itself?
23.
by sdbrown 6y ago
OK, slow down. What FDA actually said was "do not use ivermectin intended for animals on humans": https://www.fda.gov/animal-veterinary/product-safety-informa... Physicians can and do use drugs off-label at t
24.
by sdbrown 7y ago
I think this appeared on HN a few days ago: https://www.computerworld.com/article/2527153/opinion-the-un...
25.
by sdbrown 8y ago
> People ITT blaming the OP don't understand this attack always works on a long enough timescale. I'm a little dismayed by the great number of comments I had to read before someone pointed this out...
26.
by sdbrown 9y ago
Trash sorting is the absolute worst UX. A newspaper goes in paper recycling, fine. Does a glossy magazine also go in paper recycling? Cardboard goes in paper recycling. Does paper cardboard with a plastic overcoat go in paper recycling? Can
27.
by sdbrown 9y ago
So I admit that I've only skimmed the PDF on statewatch.org that the site points to, but I didn't see the "massive filtering" bit. This reads like the DMCA seems to be practiced; can someone point out to me the specific
28.
by sdbrown 10y ago
A little hacky, yes, but extremely effective. I wrote an image processing application for somewhat large time-series datasets (> 1TB) on Linux which took liberal advantage of these details to run very nicely on v2 Xeon processors. It als