rdgthree

6 ms·

1.
by rdgthree 4mo ago
xAI had a lot of negotiating power here because Anthropic had ~0 comparable options and ultimately desperately needed the compute now . So, it wouldn't surprise me if data sharing was an explicit part of the agreement
2.
Continuous inhalation of essential oil increases gray matter volume in the brain(pubmed.ncbi.nlm.nih.gov)
1 points by rdgthree 7mo ago|1 comments
3.
Solubility in olive oil predicts anasthetic potency of a compound(en.wikipedia.org)
3 points by rdgthree 7mo ago|0 comments
4.
A dead fish moves upstream when its body resonates with vortices in water [pdf](liaolab.com)
5 points by rdgthree 8mo ago|1 comments
5.
Alzheimer's disease starts in childhood in polluted Mexico City (2020)(pubmed.ncbi.nlm.nih.gov)
5 points by rdgthree 9mo ago|0 comments
6.
Incidence of Dementia Before Age 65 Among 9/11 Attack Responders (2024)(jamanetwork.com)
9 points by rdgthree 9mo ago|0 comments
7.
by rdgthree 9mo ago
Nothing to add to this conversation in particular, but just wanted to say - truly amazing paper. Well done!
8.
by rdgthree 9mo ago
Should have added one sooner! Here you go: https://1393.xyz/rss.xml
9.
by rdgthree 9mo ago
I appreciate that you feel this way, but the mechanisms behind exactly which neural circuits are activated by TMS are simply not yet fully understood. From 2024: > Transcranial magnetic stimulation (TMS) is a non-invasive, FDA-cleared tr
10.
by rdgthree 9mo ago
Of course! But also: > Although the biology of why TMS works isn't completely understood, the stimulation appears to affect how the brain is working. https://www.mayoclinic.org/tests-procedures/transcranial-mag.
11.
by rdgthree 9mo ago
The whole argument hinges on the idea of tuned resonance: https://www.nature.com/articles/s41598-025-07988-2
12.
by rdgthree 9mo ago
If you're interested in my personal chain-of-thought on the subject: This was where I started pulling this thread (October 2025): https://1393.xyz/writing/could-the-root-cause-of-alzheimers-... And this is an even
13.
by rdgthree 9mo ago
Not necessarily - I think it works like Daniel Kahneman's System 1 and System 2. Your conscious system is System 2 - when it's not working correctly, you just fall back to System 1. Independently, since the whole idea relies on re
14.
by rdgthree 9mo ago
In cognitive psychology there's all sorts of evidence that we have two distinct processes, but I don't think anyone has really mapped it to a physical system yet. Modeling two physical systems is pretty interesting though because
15.
by rdgthree 9mo ago
I think Daniel Kahneman's System 1 (habits, unconscious) and System 2 (learning, "error correction", conscious) are physical systems, and System 2 takes a LOT more energy to run. So, when you get tired, System 2 leans more an
16.
If a Meta AI model can read a brain-wide signal, why wouldn't the brain?(1393.xyz)
141 points by rdgthree 9mo ago|92 comments
17.
Alzheimer's is the symptom, not the problem(1393.xyz)
3 points by rdgthree 10mo ago|0 comments
18.
by rdgthree 11mo ago
Did you read it?
19.
by rdgthree 11mo ago
These have always felt like symptoms of the problem to me, so perhaps just downstream effects! Definitely not sure, obviously plenty of complexity to this one.
20.
Could the root of Alzheimer's be magnetic?(1393.xyz)
2 points by rdgthree 11mo ago|5 comments
21.
by rdgthree 1y ago
Interesting. Yeah, fear being a component of these things makes sense to me from an evolutionary perspective. Self-harm makes sense if your arm is pinned under a boulder. I think the psychology of these conditions is closer to that than any
22.
by rdgthree 1y ago
In my experience, I've found most deeply embedded self-destructive ideas to be rooted in fear. The brain and body are effectively locked in a paranoid "fight" state - "I know this behavior is unhealthy, but if I don&#x27
23.
by rdgthree 1y ago
FWIW the comment you are responding to was authored by AI.
24.
Are we only conscious while we're learning?(1393.xyz)
1 points by rdgthree 1y ago|0 comments
25.
by rdgthree 2y ago
You aren't too old. I've been out of school for ~10 years and AI makes me feel exactly the way you've described it. I'm trying to navigate it and find an exciting space to carve out for myself, but the future feels unc
26.
by rdgthree 4y ago
Doing this is pretty critical for SEO in a situation like this, and these businesses tend to live and die by search traffic.
27.
by rdgthree 5y ago
An interesting question that's still TBD is how well companies can operate with a significant in-office team and remote team. I think this past 18 months has proven that fully remote can work, but it may be the case that a 50/50 r
28.
by rdgthree 5y ago
(Caretaker cofounder.) I've been rejected/failed/banned by an emotionless machine a handful of times, and I don't know that anything else has made me feel quite so hopeless. I like to think a similar knot in my stomach k
29.
We replaced rental brokers with software and filled 200 vacant apartments(caretaker.com)
818 points by rdgthree 5y ago|577 comments
30.
by rdgthree 6y ago
Well said. It was frustrating how little he talked about the actual problems with the codebase, instead choosing to handwave and blame it all on React. The dig on the React team in particular was bizarre: > React’s team enjoy experimenti

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