offbynull

9 ms·

1.
by offbynull 2mo ago
If you're an engineer and want to go deeper into the core algorithms behind genomics, there's a book / course called Bioinformatics Algorithms. It was a punishing read when I was going through it a few years ago (but rewardin
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by offbynull 4mo ago
That hasn't been my experience. Bambu's documentation, including the guides and wiki, is disjointed and inconsistent. You'll often find contradictions between pages or information that isn't appropriately fleshed out. So
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by offbynull 4mo ago
> She had no desire to learn the ends and outs of 3d printers. She wanted something easy to use and reliable. The Bambu Labs printer I bought her has been just that. Where is this coming from? You absolutely need to know the ins and outs
4.
by offbynull 4mo ago
I'm also in the same boat of regret, but for other reasons. Their support team is beyond awful. I purchased an H2S AMS combo just shy of two months ago (mostly because I saw it being praised by HNers a while back) and found out recentl
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by offbynull 7mo ago
This is such a strange take. Your words remind me of past crypto hype cycles, where people pushed web3.0 and NFT FOMO hysteria. Engineering is the practical application of science and mathematics to solve problems. It sounds like you'r
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by offbynull 7mo ago
I wonder if we'll reach a breaking point with public forges, where they'll simply reject hosting a repo if it isn't from someone with a vetted background or if it detects hallmarks of LLM slop (e.g., many commits over a short
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by offbynull 8mo ago
https://offbynull.com
8.
Show HN: PAlignPrims – C++ library for sequence alignment beyond bioinformatics(github.com)
4 points by offbynull 8mo ago|0 comments
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Show HN: Xplore Path – Explore untidy data spread across scattered files/formats(github.com)
1 points by offbynull 2y ago|0 comments
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by offbynull 2y ago
Location: Boston, MA / Providence, RI. Remote: Open to either remote or hybrid. Willing to relocate: Yes, for the right role. Technologies: Python, C++, Java, Typescript, SQL, Docker, K8s, AWS, Git, GitHub. Résumé/CV: https:&#x2F
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Ask HN: Strategies to rein in or prevent bikeshedding?
20 points by offbynull 2y ago|24 comments
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by offbynull 2y ago
I program in modern C++ as well (C++23). I disagree with both "very safe" and "fun". Even with 23 there are an innumerable number of footguns throughout both the language and the standard library. Debugging code is also
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by offbynull 3y ago
I took a crack at explaining the Viterbi algorithm after learning about HMMs from a bioinformatics book I was reading. You may find it helpful, but that's assuming my interpretation of it is correct. https://offbynull.com&#x
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by offbynull 3y ago
I thought about this and we have a backup problems in place if they don't feel comfortable sharing. The context will be the same, both the candidate and the team member will be working as equals to address the problem. Although, in thi
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Ask HN: Advice on flipping SWE interviews upside-down?
2 points by offbynull 3y ago|4 comments
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by offbynull 4y ago
https://youtu.be/JA_Mfvt1IIk
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by offbynull 4y ago
The commute is what does it for me. That and I hate open plan offices.
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by offbynull 4y ago
I structure my notes on a topic as if it were a book. - There's a table of contents. - There are prerequisites for each section (links to other sections within the notes). - There's a terminology section at the bottom has short de
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by offbynull 4y ago
Around the 3 minute mark at https://youtu.be/CHD1N9vtPlE The entire interview is gold.
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by offbynull 4y ago
https://offbynull.com
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by offbynull 4y ago
> to raise prices because of my browsing habits, IP, or CC used? How would this work when most people get their flights through aggregators? I search for flights on Google Flights. I imagine Google Flights just hits a database somewhere
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by offbynull 5y ago
Not directly related to the article, but the other day I saw the "camera in use" indicator in the Android status bar while WhatsApp was open. The camera usage history showed it was being used by WhatsApp at the time (not another a
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by offbynull 5y ago
I remember this from back in the day. It felt way ahead of it's time. IIRC it originally had a single unified world, which was massive, and you could build stuff in it. It seemed almost endless. You'd just walk and walk and walk a
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Bug Brain: A game where you build brains to run a bug (2000)(biologic.com.au)
2 points by offbynull 5y ago|0 comments
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by offbynull 5y ago
Had you or your grandparents thought about maybe first asking the owner to keep the dog off the property? Maybe conveying to the owner that your grandmother has been cleaning the wall and (I'm assuming) you and your family aren't
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by offbynull 5y ago
I use a CSS [0] to style the rendered output from markdown-it [1]. It works pretty well for me. [0] https://github.com/sindresorhus/github-markdown-css [1] https://github.com/markdown-it/markdown-i
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by offbynull 5y ago
I've written... * a Java library to open up ports on your router, because at the time nothing existed for Java that handled all 3 major port mapping protocols. * a Java library implementation of Kademlia, because I wanted to learn the
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by offbynull 5y ago
They broke backwards compatibility when they moved from 8 to 9. If this is all we got out of it after all this time, IMO it wasn't worth the change.
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by offbynull 6y ago
Who is this for? Are they using it to attract interns / new grads?
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by offbynull 6y ago
First time I came across this was when I was reading a chapter on genome assembly in a bioinformatics algorithms book. It seemed like such a great solution until it got to the section about practical complications with DNA sequencing: seque

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