nik_s

7 ms·

1.
by nik_s 3y ago
The mitochondria in many cancer cell behave abberantly. For example, in many cases, they can start promoting glycolysis, in process known as the Warburg effect. They're also involved in other processes such as apoptosis and cell migrat
2.
by nik_s 3y ago
I think this is a very cynical take. Patients with gastric cancer are often in a dire situation: many of them have had their stomach removed and have generally significant difficulties with digestion, which makes consuming specific foods ve
3.
by nik_s 3y ago
I work in drug discovery (including in oncological indications), so it's always great to see new research with early, promising results! To summarize the paper: some gastric cancer models are sensitive to all-trans retinoic acid (ATRA)
4.
by nik_s 3y ago
While I agree with the general sentiment of your message, there are quite a few meta-analyses on pubmed on the long-term safety and efficacy of gastric bypass surgery. They mostly show that while some patients do end up back obese, the majo
5.
by nik_s 4y ago
It can do both - I've edited my original post to show the translation task.
6.
by nik_s 4y ago
I just tested the model [1] using an RTX3090, trying to translate a french text I found here [2]. Some observations: - The full translation of the 6:22 minute video takes about 22 seconds (17x real time) - It recognizes the language by def
7.
by nik_s 4y ago
This [1] study was pretty thorough on different fasting lengths. They tested 1422 patients for fasting lengths between 4 and 21 days, with a maximum calorie consumption of 200-250kcal and a moderate-intensity lifestyle program. It concludes
8.
by nik_s 4y ago
You can order these drugs in bulk from chemical vendors for research purposes (i.e. non-human use). Chemscene, to name just one, sells Rapamacyn at 1440 USD for 5g. EDIT: I clearly don't recommend you buying this and taking it by the w
9.
by nik_s 5y ago
Regarding the biology: - One of the strategies in drug development is to find a protein that is more present in people who have a disease versus those who don't (called "overexpressed" proteins), and attempt to stop this prot
10.
by nik_s 5y ago
You can also say that blockchains have mechanisms that prevent a government from coercing third parties from handing over your NFTs to someone else. I'll agree that the analogy wasn't perfect though - I added an edit for another a
11.
by nik_s 5y ago
I'm not sure I agree with your explanation. Most NFTs are like a title to a house. Like a title to a house, you can: 1. Prove you own it; 2. Sell it to someone. Unlike the title to a house: 1. The party certifying your ownership is not
12.
by nik_s 5y ago
I worked in the same co-working space as Wietse, Aline and Koen, the three co-founders of Citizenlab, when they were launching their service. They're a super competent team with a fantastic vision and execution - I'm excited to se
13.
by nik_s 6y ago
A minor point about the podcast: Alex Hern misunderstood the process that Craig Wright, the self-processed founder of bitcoin (Satoshi Nakamoto), needed to go through to prove that he was indeed Satoshi. Alex says that Craig needed to &quot
14.
by nik_s 6y ago
The author implies that the recent growth in tether's market cap is an indication of an incoming exit scam. A cursory glance at Coinbase's USDC's market cap [1] shows that it too is growing at almost exactly the same pace as
15.
by nik_s 6y ago
Incredibly interesting research: hopefully this pans out in human studies too. If I understand correctly, in order to achieve this: 1. a nanotube is created that contains a chemical compound (SHP1i) that inhibits the the "don'
16.
Radiolab: Fungus Amungus(wnycstudios.org)
1 points by nik_s 6y ago|0 comments
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Did Helios flight 522 crash because one man forgot to flip a switch?(theguardian.com)
3 points by nik_s 6y ago|0 comments
18.
by nik_s 6y ago
I totally understand the sentiment, and generally, when I do solo projects or projects with small teams, I also prefer light frameworks. In my experience, frameworks like Django and Rails shine when you have to collaborate with large teams
19.
by nik_s 6y ago
Congrats on the release! Actix is super exciting, and it's great to see how the community stepped up to maintain this amazing project. Is there any effort to bring a Rails/Django like framework to Rust? AWWY [1] seems to indicate
20.
by nik_s 6y ago
On top of that, the author uses aiopg rather than asyncpg[1] for the async database operations, even though asyncpg is (allegedly) a whole lot faster. 1. https://github.com/MagicStack/asyncpg
21.
by nik_s 6y ago
I'm the CTO at a data science company, and this has been my experience too. I've been lucky enough to have quite a few engineers go from zero practical experience to being able to train and deploy complex ml solutions, and the mos
22.
by nik_s 6y ago
Very nice! For those who are just skimming the link, this is actually a demonstration of the capabilities of a python package that is available on github [1]. If I understand correctly, most of the transformations are aimed at time-series d
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by nik_s 7y ago
Thank you - I came to the same conclusion while still editing my post - I think my edit and your post coincided. I clarified this edit in my original post.
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by nik_s 7y ago
I think you're referring specifically to the "political and cultural pressure in China" part of my original post. I was basing this on reporting from the New York Times [1] of the original outbreak. It very well might be that
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by nik_s 7y ago
If my original post gave off the impression of being conspiracy-theory-driven, I want to apologize, because that wasn't the intent. My original post aimed at clarifying that death rates in exponentially spreading diseases that have a l
26.
by nik_s 7y ago
> Your formula has the opposite problem, by looking at cases that have a known outcome you are biasing results towards cases that end quickly (in particular case that end in death). Unless I'm mistaken, that would only be true if ca
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by nik_s 7y ago
Indeed - thank you, I adapted the formula in the original post.
28.
by nik_s 7y ago
Indeed, you are right - I corrected the formulas.
29.
by nik_s 7y ago
The general issue with this measure of mortality (dead/(infected + dead)) is that you're assuming that the infected won't die. In a disease that is exponentially growing, a better approximation of evaluating your survival cha
30.
by nik_s 7y ago
Actually, multiple orders of magnitude...The Flu has a mortality rate of 2 per 100k [1]. [1] https://www.cdc.gov/nchs/fastats/flu.htm [edited - reformatted numbers to avoid localization issues]

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