morraa

5 ms·

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PostEra (YC W20) Is Hiring – ML for Drug Discovery – FS Developer and ML Engineer
1 points by morraa 5y ago
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by morraa 6y ago
PostEra | Full Stack Web Developer | Remote | Fulltime | https://postera.ai/ Full Job Spec: https://www.workatastartup.com/companies/13332 PostEra is building a one-stop-shop for medicinal chemistry to
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by morraa 6y ago
This looks very similar to our Moonshot open-science initiative and we love the idea of using crowdsourcing when such diseases lack commercial funding. If you know the folks who are organising this we'd be very happy to discuss with th
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by morraa 6y ago
Thanks for this. Always keen to learn from older startups but I was unable to find the company you're referring to -- any idea as to the name?
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by morraa 6y ago
This could be my misunderstanding of the definition of "designer drugs" but I interpreted this as substances which mimic controlled substances but don't trigger drug classification or testing. Assuming this definition then th
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by morraa 6y ago
Yes, certainly an interesting idea. For now our models are trained on large corpora of organic chemistry reactions so our tech has some way to go before extrapolating outside this space.
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by morraa 6y ago
Ah yes, industrializing the Chemistry part of drug discovery is certainly a blue sky dream but a field nonetheless we try to stay updated on -- hardware to do automated synthesis continues to make incremental improvements.
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by morraa 6y ago
As a company we certainly work hard to ensure our technology is used for approved drug development. We have internal alerts as a company as to the risk of compounds being entered into our system and certainly suppliers and chemical manufact
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by morraa 6y ago
Certainly we can appreciate that better designs are important though we chose to focus on synthesis as there is an oversupply of algorithms in literature/industry that can suggest designs ideas (we published a few of our own) while the
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by morraa 6y ago
Very kind comment, thank you!
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by morraa 6y ago
PostEra (YC W20) | Full Stack Web Developer | REMOTE or Bay Area | Full-time | https://postera.ai/ PostEra (YC W20) | Backend Engineer | REMOTE or Bay Area | Full-time | https://postera.ai/ PostEra is build
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by morraa 6y ago
Yes I guess I was referring to more robust, standard chemistry for which we would expect the pricing to be a little more formulaic. And you make a great point. We've been constantly reminded that virtual spaces created by CROs are not
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by morraa 6y ago
1. We ensure that the compound is pure using analytical methods like NMR and LC/MS. In our Moonshot project, the assay cascade comprises biochemical assays against the main protease (2 different assay methodologies, run in Oxford and W
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by morraa 6y ago
Ah thanks for pointing this out; it is slightly misleading. Visa is only required if applicants want to work with us in our in-person office in the Bay Area, CA. If they are a non-US citizen we sadly can't sponsor a visa. Though certai
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by morraa 6y ago
Yes absolutely, the variance of pricing across different custom synthesis providers can be surprising. This we think though is actually an opportunity to serve our end users (drug hunters) better. Generally the cost of synthesis is a functi
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by morraa 6y ago
That's a great description. For now we are focused on helping others discover novel drugs (rather than developing our own) and we think using ML to design 'recipes', while solving logistical challenges of shipping molecules a
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by morraa 6y ago
Thanks so much for the positive feedback! Forgive the very long read but yes biosciences can be a little opaque at times.
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Launch HN: PostEra (YC W20) Medicinal Chemistry-as-a-Service and Covid Moonshot
114 points by morraa 6y ago|40 comments