mansr

4 ms·

1.
by mansr 5y ago
I stopped reading at the part where he spends a full page on semantic games around the precise meaning of the word vaccine, misspelling the name of a famous dictionary in the process. This person is clearly not being honest about his intent
2.
by mansr 5y ago
A quick web search suggests that it's nothing to be concerned about. https://efsa.onlinelibrary.wiley.com/doi/full/10.2903/j.efsa...
3.
by mansr 6y ago
It's the standard method, and I see nothing wrong with it. What you suggest (deliberate exposure) is called a challenge trial. This is normally considered ethical only when an effective cure (e.g. antibiotics) is available. Even so, th
4.
by mansr 6y ago
Nothing is misleading. Half the participants got the vaccine, the rest placebo, before going about their usual lives. Now, a few months later, 95 cases have been confirmed across both groups. Of these, 90 had received the placebo and only 5
5.
by mansr 6y ago
In the Pfizer trial, all the subjects in the interim evaluation had symptomatic infection confirmed by PCR test. I'm not sure about Moderna, but it's likely to use the same or similar methods.
6.
by mansr 6y ago
One factor speeding up the phase 3 trials is the high rate of infections. Since the evaluation is done at a set number of confirmed cases among the test subjects, this happens much sooner for covid than it would be for just about anything e
7.
by mansr 6y ago
The largest percentage increase may have been in that age group, but since the base rate is very low, it still amounts to few deaths overall.
8.
by mansr 6y ago
According to the Guardian, AstraZeneca is looking at charging £3 per dose for their vaccine, assuming it gets approval. https://www.theguardian.com/world/2020/nov/16/moderna-covid-...
9.
by mansr 6y ago
This isn't the final evaluation. There will be another at ~150 cases. The numbers may seem small, but this is enough for the purpose of deciding for or against approval. Anything over 80% effectiveness would likely be approved, so it d
10.
by mansr 6y ago
I happened to read it here recently: https://www.theatlantic.com/magazine/archive/1957/02/how-goo... No, that's not a scholarly article.
11.
by mansr 6y ago
Both groups have (approximately) the same size, in the tens of thousands. The first evaluation is done when 90 or so cases have been confirmed, not knowing which group they belong to. The blinding of these subjects is then unsealed, in this
12.
by mansr 6y ago
Verifying the expected immune response (antibodies) is (part of) phases 1 and 2, if I've understood things correctly.
13.
by mansr 6y ago
Early polio vaccines did.
14.
by mansr 6y ago
Following that method will make you a Scientologist, not an expert.
15.
by mansr 6y ago
Niels Bohr, widely regarded as an expert, has said that an expert is someone who has made all the mistakes which can be made, in a narrow field. If you want to become an expert, you should presumably pick a suitable narrow field and start
16.
by mansr 6y ago
The problem addressed by git or any other serious version control system is complex. Any seemingly simple solution will be severely limited, even if it does some particular things reasonably well (e.g. Subversion). Git offers the flexibilit
17.
by mansr 6y ago
People who criticise git fall into two categories: - Those who have never used Clearcase, Perforce, or any other enterprise monstrosity. - Those who have and suffer from Stockholm syndrome.
18.
by mansr 6y ago
> just... why? It's called "virtue signalling," I'm told.
19.
by mansr 6y ago
"Hopefully some place I didn't anticipate."
20.
by mansr 7y ago
They switched from a T-rex to a hat. Makes sense.
21.
by mansr 8y ago
Yes, they do.
22.
by mansr 8y ago
> Why do keyboards have hard-wired cables anyhow? Low-speed USB devices are not permitted by the spec to have a detachable cable. The fancier keyboards are probably full- or high-speed, though, so that doesn't apply to them. As so
23.
by mansr 9y ago
His Permutation City is also good.
24.
by mansr 10y ago
What I said about inline is true of C99. C++ might be different though. It is also true that Unix linkers give an error if the final set of object files to link contain more than one external definition of the same symbol. The linker can&#x
25.
by mansr 10y ago
Unix linkers give an error if any symbol is defined in multiple object files, different or not. After all the object files have been combined, remaining undefined symbols are resolved by searching the specified libraries in command line ord
26.
by mansr 10y ago
I'm surprised this doesn't cause a multiple definitions error. Is the msvc linker really that broken?
27.
by mansr 11y ago
MP3 files, seriously? A lossy audio encoder will remove much of a static noise floor (and sacrifice some of the signal in the process). That's the point.
28.
by mansr 12y ago
GCC can do that.
29.
by mansr 12y ago
The Old Testament god strikes me as quite evil.
30.
by mansr 12y ago
Referer spam has been around almost as long as web analytics. What's new is that they found a way to infiltrate Google Analytics, which previously avoided them somehow. I'm surprised Google hasn't come up with a countermeasur

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