klmr

6 ms·

1.
by klmr 2mo ago
It’s a POSIX thing, and it has nothing to do with the file extension. The OP is right: file extensions are optional (and, as shown here, often actively misleading), but if they’re present they should match the actual file type. Which, in th
2.
by klmr 3y ago
Oh, I totally agree that ‘renv’ probably solves 95% of problems. But those pesky 5%… I think that most problems are ultimately caused by the fact that R packages cannot really declare versioned dependencies (most packages only declare `>
3.
by klmr 3y ago
> But in all honesty for the pharmaceutical industry it’s mostly momentum that keeps R on top I can’t agree with this: especially in PK/PD, R is only just now taking over from the previous (closed-source) systems. Momentum would k
4.
by klmr 3y ago
> I can’t remember the last time a library incompatibility led to a show stopper. Oh, it’s very common unless you basically only use < 5 packages that are completely stable and no longer actively developed: packages break backward
5.
by klmr 3y ago
> That's not a lot Indeed, that wouldn’t be a lot: the framing in the article is grossly misleading. The actual number of protesters this weekend was hundreds of thousands, and plausibly >1M (not “tens of thousands”), according t
6.
by klmr 3y ago
I’m not saying this doesn’t happen but I can’t remember ever having been asked to install a root certificate when joining an airport wifi. And I am confident that this has never happened when I’ve flown out from Gatwick.
7.
by klmr 3y ago
> why are there not mass protests about this? Because we hadn’t heard about this case before. — At all. If the vague information in this article is actually corroborated there’ll be an outcry alright.
8.
by klmr 3y ago
The entire point of TLS (let alone E2EE!) is to make something like this particular scenario safe.
9.
by klmr 3y ago
Why? Because all typical, existing applications written for POSIX systems use the POSIX API (usually indirectly) to interact with the filesystem and perform IO. Being able to use that vast ecosystem of existing applications seamlessly with
10.
by klmr 3y ago
> … at Google, which i suspect is one of the companies you are referring to. Just to clarify: no, I was referring to companies which are using products from the company behind cunoFS, and which share the actual code base of the functio
11.
by klmr 3y ago
> this is not a recipe for stability of your binaries I see the point in theory, but it works incredibly well in practice. The specific technology has been used in production by major companies for years. It even carefully works around
12.
by klmr 3y ago
> but what has this to do with storage systems? The article is about POSIX compliance (or lack thereof) of storage systems. And the article does not imply that “POSIX … sucks”. On the contrary: the answer to the rhetoric question in
13.
by klmr 3y ago
It’s pretty clear that the article is only comparing object storage with POSIX in the context of filesystems, not with all of POSIX.
14.
by klmr 3y ago
If you save the offset (and you are , if you use a borrowed string) you can retrieve the original source code by re-reading the input file on the fly. This is expensive (due to IO, but especially also since you need to re-lex and recompute
15.
by klmr 3y ago
It’s also completely untrue. In reality the high cost is not because of greed but because of high manufacturing cost and the necessity for long hospital follow-up. Novartis is also not the only manufacturer providing CAR-T drugs at a high p
16.
by klmr 4y ago
> I recall when the pipe operator was first being proposed the argument for it was that it'd enable workflows that felt more like Excel. Where are you getting that from? To start with the pipe operator has been independently reinv
17.
by klmr 5y ago
Yes, it switches to a different audio codec, that’s unavoidable due to bandwidth limitations. However, macOS insists on using a worse codec than necessary (SCO instead of SBC) and, at least with my MX4 headphones, this badly scrambles audio
18.
by klmr 5y ago
Next week on HN: “curl: A command line tool and library for transferring data with URL syntax”. Anyway, the submission led to several very interesting technical comments so I don’t hate it.
19.
by klmr 5y ago
I’m a huge fan of the Sony high-end line, and am currently using the WH-1000XM4 myself. They’re excellent, but they do share quite a few of the annoyances listed in the OP article (in particular the delay when going from call to audio and v
20.
by klmr 5y ago
It’s a weird quote anyway since there is commercial, proprietary software for DNA sequence analysis. Just a few examples of companies in this space are Sentieon, Edico (acquired by Illumina) and Parabricks (acquired by Nvidia). And Michae
21.
by klmr 5y ago
I dunno, I don’t think it’s that obvious: the physical movement in an LCD is across tiny masses and distances (at molecular scale); the network signal has to cross a distance that’s many orders of magnitude larger. Comparing these two t
22.
by klmr 5y ago
> it wanted to blast crap into /usr Homebrew only ever writes into `/usr/local`, which was unused by macOS until very recently (though unfortunately a few third-party tools also use it and lead to very occasional conflic
23.
by klmr 5y ago
> A modification in the frame of mind of genetic understanding is performed on a viral cell. Let me be frank: this sentence is nonsense technobabble. > A segment of viral genome which encodes part of the body viral is excised and m
24.
by klmr 5y ago
> It is a simple fact that there are two major definitions on the Wikipedia entry for gene therapy: I read this as a single definition rather than two distinct ones but, regardless of how you read this, mRNA vaccines do neither of thes
25.
by klmr 5y ago
Title: “Manufacturing gene and RNA therapies” “A challenge for both gene and RNA therapies is getting the nucleic acid molecules into a cell. […]”
26.
by klmr 5y ago
These findings are probably spurious and caused by artefacts of their methods rather than real. In particular, the preprint you’ve linked to had glaring methodological flaws [1]. A revised version of the article [2] has addressed some , bu
27.
by klmr 5y ago
> Here is an example where Harvard Stem Cell Institute discusses mRNA therapy as gene therapy: https://hsci.harvard.edu/translation/what-are-drugs-4-gene-t ... And the very next paragraph (in its heading, no less) ma
28.
by klmr 5y ago
Odd, why would this be? Read and write operations on temporary files need to go through the kernel and thus lead to frequent context switches. The same shouldn’t be true for a string buffer except on reallocation.
29.
by klmr 5y ago
No, it doesn’t depend on the definition. This isn’t a point of contention amongst experts. The article you cite is simply wrong (in particular, its claim about the classification of mRNA vaccines as gene therapy in Europe is categorically f
30.
by klmr 5y ago
> There seems to be an assumption underlying medicine that things must be true at the population level for them to also be true at the individual level. That really isn’t true: medicine as a field does not have this assumption, and rare

More ›