klevertree

26 ms·

1.
by klevertree 1y ago
Wrote about this in the context of repurposing, which is a pet interest of mine: https://trevorklee.substack.com/p/another-entry-for-the-repu...
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by klevertree 1y ago
We're still prototyping and testing, but you'll probably have to eat it twice a day to get complete coverage. It needs to be in the gut at the same time as the plasticizer to have any effect.
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by klevertree 1y ago
Not a bad idea for your health, but it won't trap plasticizers. We're modifying the beta glucan to have many tiny, "sticky" pores to trap the chemicals in the gut, so they go out with the rest of the beta glucan. Pure be
4.
by klevertree 1y ago
Reports like this on the dangers of DEHP is exactly why I started work on NeutraOat ( https://neutraoat.com/ ), a modified oat fiber supplement designed to trap plasticizers in your gut before they can get into your bloodstre
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Show HN: Preventing plasticizer absorption with an oat fiber-based supplement(stellar-melomakarona-30fbb7.netlify.app)
2 points by klevertree 2y ago|1 comments
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by klevertree 3y ago
Yes, what do you think the pk trials and liver experiments would involve if not people who have a variety of phenotypes?
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by klevertree 3y ago
Author here. Thanks! I'm pretty sure most of the negative effects of SSRIs were discovered in phase 2 trials, though. Pk trials aren't usually powered to find adverse effects in subpopulations like teenage patients. Same thing wit
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by klevertree 3y ago
Author here. As someone who works in pharma, organ on a chip models are not even close to being relevant to providing accurate PK curves for oral absorption. The state of the art is trying to make it work for cutaneous absorption and that&#
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by klevertree 3y ago
Author here. That's not what I said. Please don't be a jerk on the Internet.
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by klevertree 3y ago
Cyclosporine and tacrolimus, if you look at the range in any of their pk trials you'll easily see 10 fold variability.
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by klevertree 3y ago
Author here. Enzyme polymorphisms are tricky and would require a whole different blog post. Some drugs they matter a lot for, some drugs they do not. I actually have not found any drugs with 10-fold variability that could be ascribed solely
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When rational drug design meets an irrational disease(trevorklee.substack.com)
1 points by klevertree 3y ago|0 comments
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A miracle drug sold over the counter(trevorklee.substack.com)
23 points by klevertree 4y ago|20 comments
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Letter to a Young Biotech Founder(trevorklee.substack.com)
1 points by klevertree 4y ago|0 comments
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How to Manufacture a Drug(trevorklee.substack.com)
1 points by klevertree 4y ago|0 comments
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What to do when the tide is going out(trevorklee.substack.com)
1 points by klevertree 4y ago|0 comments
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How I've tried to fix my lower back pain(trevorklee.substack.com)
2 points by klevertree 4y ago|1 comments
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Fundraising for a drug trial in feline autoimmune disease(trevorklee.substack.com)
2 points by klevertree 4y ago|0 comments
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How much it costs to develop a drug for cats(trevorklee.com)
1 points by klevertree 4y ago|0 comments
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by klevertree 4y ago
Do you have any connections there, by any chance? Always looking to talk to more vets.
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by klevertree 4y ago
The corporate attorney agreed not to require me to pay any of their invoices until I closed a seed round, while the patent attorney let me pay their invoices a full year after I received them. These sorts of arrangements are common with att
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by klevertree 4y ago
I'm sorry to hear about your calico. Stomatitis is really a terrible disease.
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by klevertree 4y ago
Unfortunately, the reality of trying to cure animals is that sometimes you accidentally hurt animals. That's also the reality of trying to cure humans. This is the exact same issue vets face when they perform surgery on your cat, and i
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by klevertree 4y ago
Trying to cure a disease that gives cats such bad mouth sores that they sometimes can't even drink water isn't exactly "pushing crap". We're trying to make it to profitability so we can get to the point where we can
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I'm making drugs for cats(trevorklee.substack.com)
170 points by klevertree 4y ago|98 comments
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Obesity's relationship with type 2 diabetes is weird(trevorklee.substack.com)
18 points by klevertree 4y ago|26 comments
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A Medical Thought Experiment(trevorklee.substack.com)
2 points by klevertree 4y ago|0 comments
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To improve medical trials, justify exclusion criteria(trevorklee.substack.com)
83 points by klevertree 4y ago|50 comments
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Ask HN: Are you applying to YC as a bio company?
1 points by klevertree 4y ago|0 comments
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The Epstein-Barr virus causes multiple sclerosis. So what?(trevorklee.com)
3 points by klevertree 5y ago|0 comments

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