kion

9 ms·

1.
by kion 10mo ago
I'm not a biochemist, so I can't say with any authority, but presumably its to do with the 3rd antagonist and its impact on glucagon. Most of what I have heard is through Reddit communities for the on-market drugs (1st and 2nd ge
2.
by kion 10mo ago
retaglutide is the next gen (3rd) GLP-1 which is in phase 3 trials now. It is a triple antagonist (current are dual GLP-1/GIP). It adds glucagon, and apparently that comes with not only greatly increased weightloss, but also wicked s
3.
by kion 1y ago
I've been on Zepbound for ~25 weeks now and one of the first things my doctor told me was that this was a lifetime drug. He pointed out that I had a choice, of lifetime drugs. I needed to do something to get my cholesterol under contro
4.
by kion 1y ago
Others have made similar comments, but tree-shaking, symbol culling and anything else that removes dead code after its already been distributed and/or compiled is too late IMO. It's a band-aid on the problem. A useful and pragmat
5.
by kion 1y ago
The article is about Rust, but I was commenting on dependencies in general. Things like --gc-sections feels like a band-aid, a very practical and useful band-aid, but a band-aid none the less. You're building a bunch of things you don&
6.
by kion 1y ago
I probably mischaracterized this as its been a while since I did more than trivial Rust. AFAIK its not possible to depend on only a part of a module in Rust though right? (At least without an external build system) For example, you can&#x2
7.
by kion 1y ago
LTO only gets you so far, but IMO its more kicking the can down the road. The analogy I use is cooking a huge dinner, then throwing out everything but the one side dish you wanted. If you want just the side-dish you should be able to cook
8.
by kion 1y ago
IMO any system where taking a dependency is "easy" and there is no penalty for size or cost is going to eventually lead to a dependency problem. That's essentially where we are today both in language repositories for OSS lang
9.
by kion 1y ago
The thing I dislike about Waymo is other drivers. I've now had it happen twice that a car will fully blow through an intersection because they know a Waymo will slam on the breaks to avoid a collision. They basically abuse the car&#x2
10.
by kion 2y ago
I looked into this last year, a significant part of the cost is in new hardware, both on the vehicles, but also sensors spread through the system. They all need commercial grade RF systems that allow for 2 way signaling communication and i
11.
by kion 3y ago
Tuition and non-tuition costs have both absolutely skyrocketed and made CSUs unaffordable for a lot of people. I went to Cal Poly, my entire freshman year was ~$6000 in 1997. It was an even split between $3k tuition and 3k student housing&
12.
by kion 5y ago
> "too cumbersome" and require re-uploading the same app package repeatedly, but it would work. This is true and "too cumbersome" is worth expanding on. Without specific targeting what is delivered to the device, 100
13.
by kion 6y ago
> If you don’t have a problem with user quality then sure, avoid the verification step. But if you have a good reason for the verification step then don’t sweat the drop-off rates. If you have any contact method for the user (email, SMS,
14.
by kion 6y ago
> Only 38% of people did this. If I had instead captured everyone as soon as they showed enough interest to leave an email address, I could’ve increased my conversion rate by 250%. How many of these were real losses and how many were peo
15.
by kion 7y ago
This appears to have been fixed since the posting. Links in the search results work again in lynx.
16.
by kion 10y ago
Not if you include CA state taxes and property taxes. You can pretty easily hit 50% somewhere north of 250k, which for a 2 income household in the bay isn't outlandish.
17.
by kion 10y ago
So don't look at it as percentages. Look at it as a question of how comfortable is your situation. I'm in roughly the same position as you tax wise. We pay slightly less, about 48%, to taxes of one form or another. However we&
18.
by kion 11y ago
Chrome on iOS has some input handling issues inside the iframe.
19.
by kion 12y ago
To answer the 2nd part of the question: vmnix was the name of the Linux kernel module that was loaded during the Service Console's boot process. The terms "Service Console", "Console OS (COS)" were at times used int
20.
by kion 12y ago
Nope, that stuff is all gone with the ESXi product. The vmkernel can bootstrap itself now. Basically the old 1.0 - 4.0 process for _ESX_ was like this: * Bootloader * Linux Kernel boot * Load VMnix module. * Load VMkernel * hardware control
21.
by kion 12y ago
vmnix aka Service Console aka Console OS aka the Fuzzy part, was part of ESX, which was discontinued with the 5.0 series of ESX products.
22.
by kion 12y ago
This is the sort of thing I hope to see a lot more of from Rust. Things that would traditionally be done in C/C++ moving to a new language with modern features. I'm very hopeful this trend will continue.