ijustlovemath

5 ms·

1.
by ijustlovemath 19d ago
The latest CGMs are definitely not cheap on the R&D side. The obvious implementation is really susceptible to interference from common drugs, which is a really expensive thing to fix. They're also trying to get wider adoption in th
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by ijustlovemath 22d ago
I'll be showing my bias here, but you're probably referring to NICE-SUGAR, which I think suffered mainly from having a pretty uninspired control algorithm. We built and simulated it and several other clinical protocols and it had
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by ijustlovemath 22d ago
oof, that's what I get for commenting late! I was thinking of that 23% number.
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by ijustlovemath 22d ago
Recall that GLP-1s were originally designed as next-generation long acting insulin modulators; they're a form of passive control. The CGM gives you data to act on, or at the very least observe. I find, from my experience wearing them a
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by ijustlovemath 22d ago
Drug interference (with the sensor chemistry) and perfusion (which the sensor needs to function) are two major problems that a hospital presents that are not present in ambulatory (outside the hospital) use. Also the FDA has not approved an
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by ijustlovemath 22d ago
If the large studies are to be believed, you could save hundreds of thousands of lives and many billions in excess expenditure, because stable blood glucose shortens length of stay. People with diabetes alone account for 60% of hospital exp
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by ijustlovemath 22d ago
I've had the fortune to work with several CGM OEMs behind the scenes as part of our work developing an artificial pancreas, they all have a secret lactate signal!
8.
by ijustlovemath 22d ago
None have been approved for hospital use as of yet, which is the next frontier.
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by ijustlovemath 22d ago
Ah yes, I see what you mean! Ketones are not inherently bad, just the accumulation of them w.r.t having diabetes. Should have made that more clear.
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by ijustlovemath 22d ago
Lactate's available in the internal engineering data of these sensors, just not something that anyone has wanted to spend the time or money to qualify with the FDA. It essentially comes "for free" due to the chemical reaction
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by ijustlovemath 22d ago
It can happen in people with uncontrolled T2D as well. My cofounder is a pediatric ICU doctor who has treated hundreds of DKA patients. Also there wasn't really a relationship of the keto diet to the rest of my post, just using it to c
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by ijustlovemath 22d ago
Cardiac surgery, burn units, ICU, neuro come to mind. All have been studied to show mortality and complications improvements with AGC, but unfortunately the commercial technology has not materialized yet.
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by ijustlovemath 22d ago
There are 6 month implantable CGMs, they're just quite expensive.
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by ijustlovemath 22d ago
Lactate actually comes for free with blood glucose when you measure it with a chemical sensor, it's just not something that's usually asked for. I definitely think it would be considered a form of doping to use it in competition,
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by ijustlovemath 22d ago
There is a major IP holder in the space who is asserting their ownership, so even if they could solve the technical challenges, they might not be able to come to market.
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by ijustlovemath 22d ago
The difference is that these only measure blood sugar, while the new system also measures ketones, of keto diet fame, which are leading indicators of a really dangerous situation called diabetic ketoacidosis. It's treatable with a hosp
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by ijustlovemath 22d ago
a regulated blood sugar level aids massively in cellular repair, inflammation reduction, and immune response. These are well studied and established. I could absolutely see a top athlete using AID in the future as part of a recovery routine
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by ijustlovemath 22d ago
non-invasive continuous blood sugar measurement is mired in patents and technical challenges. Turns out it's really difficult to disambiguate the absorption lines of glucose from other similarly shaped molecules when you're also d
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by ijustlovemath 22d ago
Automated glucose control will be the next frontier in so many areas of healthcare. I'm still skeptical that anyone will be able to noninvasively and accurately sense blood sugar, but I'm glad people (especially kids with T1) will
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by ijustlovemath 28d ago
I got my first one at age 27. A third just got removed. Living with the constant mole vigilance of that is rough, but I am glad I've learned to identify them. I think knowing the ABCDEs of it should be more widely spread, as removing a
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A partial digestion of the HRT counterexample(terrytao.wordpress.com)
35 points by ijustlovemath 1mo ago|2 comments
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by ijustlovemath 2mo ago
Curious what your distribution is, as a ~400 person that thought they did more.
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by ijustlovemath 2mo ago
Why does Rust feel like a bad choice to you? In my experience shipping med device software, it's great for keeping the code that teams write cohesive and correct
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by ijustlovemath 2mo ago
editions could be self-describing as to certain semantic changes, and you could embed that with the file. older versions could safely ignore it and newer versions parse and run it. you could also force things like "editions must be dec
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by ijustlovemath 2mo ago
Helene survivor here. I will be spreading the word about this project and keeping some APKs for if the shit hits the fan again. FDroid being able to sync between local devices means all you need is to get fdroid onto someones phone. Wish th
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by ijustlovemath 2mo ago
To be clear, all of that setup happens once on your host machine, then you never have to think about it again! You can compose to your heart's content. I think podman just doesn't want to commit to a particular DNS solution so the
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by ijustlovemath 2mo ago
I had to do some extra stuff for my containers, here's some info from a tutorial I wrote: Following the Arch wiki: # Dependencies `yay -S podman slirp4netns aardvark-dns` # Setup podman-compose and the venv ``` python -m venv .venv sou
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by ijustlovemath 3mo ago
what kind of stuff is in your compose?
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by ijustlovemath 3mo ago
We made a very functional job queue in Postgres with PostgREST. highly recommend, as the automatic REST API makes building new clients a breeze
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by ijustlovemath 4mo ago
Probably with Special Window Settings (right click top bar of your mpv window)

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