gww

7 ms·

1.
by gww 20d ago
I have multisensory aphantasia. I assumed everyone was like this until I read an HN thread a long time ago. I have a very strong inner monologue. For example, I can hear part of a song in my head. Ie the guitar but it's my inner voice
2.
by gww 4mo ago
A few of the older 3d MMORPGS did try to instill some of those mechanics. Examples include: 1) Asheron's Call (which had a very active mod scene and now an emulator scene). I don' think the servers are nearly as popular as UO tho
3.
by gww 6mo ago
I have worked at a sequencing center before. DNA contamination is easier to mitigate because the lab disposables aren't made out of what you are testing. Disposables are almost always plastic and tend to have minimal DNA contamination.
4.
by gww 6mo ago
I haven't really read the studies but shouldn't they have negative controls to negate these effects? Wouldn't that let the author's correct for a baseline contamination level in the lab?
5.
by gww 7mo ago
That is how I became serious about programming. I played around a bit but I never really wrote anything useful until I started playing Asheron's Call. I learned C++ to write bots and other plugins for Decal (an embedded mod framework).
6.
by gww 7mo ago
There are other examples of oncoviruses including: Epstein-Barr virus and Human herpes virus 8 (Kaposi's Sarcoma). Makes me wonder: Is the cancer "industry" searching for causes or just after-the-fact treatment? There are b
7.
by gww 8mo ago
ed was the hardest thing for 12 year old me to understand.
8.
by gww 8mo ago
I played Aardwolf briefly but I mostly stuck to a nightmare/LP MUD that is still around but essentially empty. I learned to code (which ended up being a gateway to C/C++), grief, and be compassionate to new players.
9.
by gww 10mo ago
There's a second paper on the same topic published in Nature [1] [1] https://www.nature.com/articles/s41586-025-09771-9
10.
The levers of political persuasion with conversational artificial intelligence(science.org)
4 points by gww 10mo ago|1 comments
11.
by gww 1y ago
I have a different problem with my M3 Macbook Pro. If I leave chrome (sometimes other apps too) open with the macbook plugged in and the lid closed the computer will get very warm and stay very warm until I unplug it / close chrome. E
12.
by gww 1y ago
Reminds me of one of my favorite Simpsons lines: "Aw, you can come up with statistics to prove anything, Kent. Forty percent of all people know that"
13.
by gww 1y ago
They are used somewhat commonly in bioinformatics where lookup tables can have long keys and many entries [1]. 1. https://en.m.wikipedia.org/wiki/Bloom_filters_in_bioinformat...
14.
by gww 2y ago
This is a great analogy. One small change is that there are two ways to reassemble it. One is to try to blindly put the pieces together and fork a teacup (read assembly) vs trying to use a picture of the teacup to figure out where the piece
15.
by gww 2y ago
They didn't sequence the whole human genome (~3 billion bases) for multiple reasons. I am not an expert on ancient DNA but I will try to explain the paper as best I can: 1. Contamination with other flora and fauna DNA 2. Relative low
16.
by gww 2y ago
The BWT based FM-index is one of my favorite data structures. It's used frequently for DNA mapping, where the 4 letter alphabet can be encoded in two bits and the occurrence function can use clever caching, bit bashing and the pop coun
17.
by gww 2y ago
Users of these kinds of tools should check that their marker genes are associated with the labelled cell types. There are known markers for many cell types across multiple organisms.
18.
by gww 2y ago
Will check it out. Thanks a lot
19.
by gww 2y ago
Cool thanks
20.
by gww 2y ago
Could this also be adapted for gene set enrichment? For example, if I had a set(s) of genes from an ATAC-seq experiment would it be able to guess their function / cell types?
21.
by gww 2y ago
This is really useful thanks for sharing. My students and myself tend to waste a lot of time annotating clusters and have not found a reasonable solution yet. This will be fun to try.
22.
by gww 2y ago
It is common for human cancers to be polyploid after accumulate whole genome doublings (WGD), where a tumour cells goes from being approximately diploid to tetraploid. Different tumour types have higher rates of WGD, for example, glioblast
23.
by gww 3y ago
I am going to steal that name. I find that computational overcooking happens more and more because the easy questions that can be asked with sequencing datasets is starting to dry up.
24.
by gww 3y ago
I would argue that these are some of the most important algorithms in bioinformatics/biology. They have a wide range of applications.
25.
by gww 3y ago
Grails test isn't for somatic mutations but cancer specific DNA methylation patterns. DNA methylation is slightly more challenging to work with due to how the methylation is identified from sequencing data. There's a chemical of e
26.
by gww 3y ago
Beautiful book I used it in undergrad. The only problem with the book is its size; it's terrible to lug around in a backpack.
27.
by gww 3y ago
You are a bit behind on the available read lengths. The Oxford nanopore can produce reads as long as 300kb (k as in kilo) and the PacBio hifi can product 15 to 20kb reads. Finally a now defunct technology by 10x genomics called linked read
28.
by gww 3y ago
I am a bioinformatics scientist that works almost entirely remotely. I miss the impromptu discussions that happen around the lab, which can help solve a problem you or a co-worker is stuck on or they can lead to a new and interesting collab
29.
by gww 3y ago
Sounds like a way for HowToBasic to generate new YouTube video ideas.
30.
by gww 3y ago
My first real coding education was Pascal on a VAX/VMS terminal in high school. It was a great experience and I miss the monochrome orange screens

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