doctoring

6 ms·

1.
by doctoring 10mo ago
I mean, I do? As do most of my friends who are homeowners. We are constantly asking each other for recommendations for people who can do X. Hire a couple of disasters, and you will appreciate that a good relationship with a good contractor&
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by doctoring 1y ago
The not so big secret is that we can detect cancer early in a lot of people, but we also would detect a lot of not-cancer. We don't currently know the cost/benefit of that tradeoff for all these new types of screening, and therefo
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by doctoring 1y ago
I think this essay touches on but slightly conflates "younger" with "inexperienced". Younger people are inexperienced at more things in life, sure. But if you write essays about things that are new to the world (new tech
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by doctoring 2y ago
Public service announcement: There are already blood tests for detecting pancreatic cancer and other cancers on the market, and more coming, depending on where you live. So get tested, if this is something you are worried about. I believe t
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by doctoring 2y ago
I had the same question. From their FAQ ( https://boomsupersonic.com/faq ): > Will Overture use afterburners like Concorde? > No. Overture will fly without the use of afterburners, meeting the same strict regulatory noi
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by doctoring 2y ago
I don't know for other countries, but for the United States, "medical students are no longer choosing it" is very very untrue, and it is trivial to look up as this information is public from the NRMP (the organization that ru
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by doctoring 2y ago
Whole body MRI is fairly available in major metro areas, though not cheap and not very sensitive or specific. The Galleri blood test screens for a range of cancers (sensitivity varies by cancer) and is ~$900, although you need a doctor to o
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by doctoring 2y ago
> "The tests... cover topics such as U.S. audit standards, professional ethics and independence..." Ethics, you say? > "...involved hundreds of professionals, including partners and senior leaders such as the now former
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by doctoring 2y ago
I love rice cookers! Rice cookers (usually) make clever use of 1) alloys whose magnetism depends on temperature and 2) the fact that boiling water occurs at a fixed temperature. With a "trigger" temperature just above the boiling
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by doctoring 2y ago
Very interesting overview of the technological / materials breakthroughs to enable miniaturization. From a physician (specifically radiologist) perspective, I'm a big fan of handheld/point-of-care ultrasound and am excited ab
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by doctoring 4y ago
They list it under their "legal documents" page: https://www.nabla.com/docs/business-associate-agreement
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by doctoring 4y ago
The article mentions: "...sequencing DNA from blood samples and tumour biopsies, to look for mutations that are found in the tumour but not in the blood." This is pretty common for most cancer genotyping tests. (Sometimes they com
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by doctoring 4y ago
Wait, but we do have the tools... We can (and do) cure so many cancers. Usually with surgery, +/- chemo/radiation. Sometimes just radiation. It's hard to overstate how curable most cancers are at early stage -- for some it&#x
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by doctoring 4y ago
Your original comment stated: > They won't work for in situ tumors, almost by definition. Which isn't true. The studies from multiple companies' tests demonstrate that they _can_ detect in situ tumors. Not always super dup
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by doctoring 4y ago
This isn’t quite right — I think you’re thinking about circulating tumor cells (CTCs). These tests on the other hand detect circulating tumor DNA (ctDNA), among other things. It is well known that tumors shed DNA and other material more tha
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by doctoring 4y ago
Per the article, Grail’s test is already on the market at $949. Insurance does not cover this —- yet. (That is a big goal of many of these companies). This is not cheap but not also not insane. Grail’s test screens for 50 different cancers
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by doctoring 5y ago
I was visiting family in NE Atlanta last fall. These spiders were everywhere -- coating houses, trees, power lines. And yet, they do not seem to come into homes. Even the exterminators they called said so.
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by doctoring 5y ago
Usually not! PET scans are limited in resolution when you get down to the sub-5 mm or so range due to scanner technology and fundamental limits of the physics of positron/electron annihilation & photon emission. A typical MRI (i.e.
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by doctoring 5y ago
Rituximab is a monoclonal antibody which targets a B cell surface protein, CD20. Monoclonal antibodies are pretty cool, in that we've figured out how to make a thing that our bodies normally make, and engineer versions that target spec
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by doctoring 5y ago
Wow, I am so sorry. Thank you for sharing part of Melanie's story. Your thought about the drugs maybe limiting the effect of the CAR-T is an interesting one and the subject of ongoing investigation. One common drug used for CAR-T relat
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by doctoring 5y ago
Choosing another target is a good idea! But, as you can imagine, we've been trying a lot of targets and they don't seem to work as well. One issue is that CD19 is the only known target that is a) expressed throughout the entirety
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by doctoring 5y ago
Yes. B-cells (normally) make antibodies, so these patients usually receive regular infusions of antibodies by IV (which come from blood donations) to keep their circulating antibody levels up.
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by doctoring 5y ago
There's a couple of reasons for why a person may relapse after CAR-T therapy, and much is still under investigation. One large category is that the attack on the CD19 target has selected for B-cells which have a mutated CD19 or do not
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by doctoring 5y ago
CAR-T therapy is incredibly complex and incredibly cool. One of the reasons CAR-T therapy has been so successful thus far with certain lymphomas and some leukemias is that there is a specific surface protein (CD19) which is expressed in al
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by doctoring 5y ago
It’s worth noting that a test’s performance (i.e. sensitivity/specificity) is tunable. That is, Grail is making a decision of where to set its threshold for a positive result, in effect selecting where it wants to be on the ROC curve.
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by doctoring 5y ago
Hey, radiologist here. So, the question of "what next" after a positive result on one of these tests is still... open. The Grail test provides indication of likely tissue of origin, so a likely first step may be a targeted study (
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by doctoring 5y ago
Highly encourage reading the paper referred to (but not linked!) in the article: https://www.annalsofoncology.org/article/S0923-7534(21)02046... Some good breakdown of test performance by stage and cancer types.
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by doctoring 5y ago
Cancer radiologist here! I don't know about "highly accurate", but certainly pretty fucking good. Because for most of those cancers for most populations, the asymptomatic detection rate is much, much lower. Like close to 0%.
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by doctoring 6y ago
They are trying. For what its worth, faculty across multiple departments (including those radiologists) stepped up and declined their scheduled vaccine appointments until residents get vaccinated first. It's a big place made up of most
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by doctoring 6y ago
The residents who didn't get it: those working 80+ hrs/week in the emergency room, in the ICU, intubating patients, operating on patients, etc etc etc Some people I know of who got it instead: Radiologists who primarily work from

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