david_l_lin

5 ms·

1.
by david_l_lin 3y ago
I should clarify: there’s some more details to why S mutans actually requires low pH. The correct term wouldn’t be “tolerate low pH” but rather “requires low pH” for its stable colonization. S mutans creates incipient lesions by making acid
2.
by david_l_lin 3y ago
This story has been around for far too long and evidence is unbelievably weak, and the claims border on fraudulent. 1. The claim that this strain outcompetes the same S mutans from occupying the same niche cannot be true unless this strain
3.
by david_l_lin 3y ago
Indeed we do! We have an oral microbiome test you can find here: https://www.bristlehealth.com/pages/products and our first probiotic here: https://www.bristlehealth.com/pages/probiotic All the s
4.
by david_l_lin 3y ago
Except that we can! The oral microbiome can be modulated to get exactly what you’re asking: remove pathogens that are good at creating acid and replacing them with ones that are good at remineralizing. Shameless plug for my company (Bristle
5.
by david_l_lin 4y ago
Majority were not on medication. >Eighty-five FES patients and 35 CHR subjects were psychotropic medication naïve and all participants were free of substance abuse, suicidal ideation, and unstable medical illness.
6.
by david_l_lin 4y ago
Super interesting study! Other studies also associated the oral microbiome with cognitive health, like depression and Alzheimer's, but this is an interesting finding. >H2S-producing bacteria exhibited disease-stage-specific enrichme
7.
by david_l_lin 4y ago
In the last 5 years or so, research has shown tight associations between specific pathogens in the mouth and inflammation throughout the body. Fusobacterium nucleatum and colorectal tumors, Porphyromonas gingivalis and tangles in the brain,
8.
by david_l_lin 4y ago
well, for the most part in healthcare we treat symptoms not causes. cavities caused by acid producing bacteria? drill and fill gum disease caused by oral dysbiosis? bone and gum grafts diabetes from autoimmunity? insulin high cholesterol fr
9.
by david_l_lin 4y ago
It's interesting that we've become so obsessed with the gut microbiome even though stool only captures a tiny fraction of the composition of the gut. Similarly, the salivary oral microbiome has also been correlated with mental dis
10.
by david_l_lin 4y ago
All you need to do is visit the dentistry reddit sub and look at threads like this: https://www.reddit.com/r/Dentistry/comments/vnv25a/how_is_he... . They all operate on "production" because bil
11.
by david_l_lin 4y ago
I think it's because incumbents in the space have played a huge role in preventing adoption of new technologies that actually prevent disease. Dentists make money not from preventing disease, but from performing procedures when disease
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by david_l_lin 4y ago
I wonder if the same is happening to mouth microbes, which could explain the epidemic of oral disease in developed countries.
13.
by david_l_lin 4y ago
Fee for service in health care is not compatible with prevention. The vast majority of oral issues are preventable because they stem from bacterial infections. Dentists take full advantage of information asymmetry: patients assume the denti
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by david_l_lin 4y ago
Honestly, neither. Biology is complex and messy, and often not at all intuitive.
15.
by david_l_lin 4y ago
Just watched John Q (2002) last night, and can't believe that despite all the attention it gets, nothing has changed at all. Can't say I'm surprised though.
16.
by david_l_lin 4y ago
A lot of studies have shown that literally taking up genomic space is a function. So by definition, all genes have a function. Non-genes have functions. The topological organization of genomes is a function.
17.
by david_l_lin 4y ago
Even an exogenously expressed non-human protein still has a "function". even if you force it to be expressed. We may not understand its effects, but it is certainly doing something. Even just taking up a space is a biological func
18.
by david_l_lin 4y ago
> "this outcome fails when this byte of data is missing" The outcomes here are not failures, they are measurable phenotypic differences, which they use to group genes into phenotypic outcomes. The typical "knockout -> f
19.
by david_l_lin 4y ago
All genes have a function. This paper helps us understand genes of unknown function (which is a LOT of them). Some of these functions are not intuitive: maybe they regulate the function of another protein, maybe they only function in the co
20.
by david_l_lin 4y ago
Not really? It says that some genes result in the same outcome when knocked out as other genes, and identifies novel genes that putatively participate in the same pathways as others. This helps get at the potential function of genes without
21.
by david_l_lin 4y ago
Bristle cofounder here. In short, we found that people using an electric toothbrush have increased commensal species in their oral microbiome compared to those using a manual brush. We looked at potential confounders, and found that this ef
22.
Are electric toothbrushes better for your oral microbiome and health?(bristlehealth.com)
6 points by david_l_lin 4y ago|1 comments
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Bristle (YC W21) Is hiring to analyze the oral microbiome and prevent disease(bristle.notion.site)
1 points by david_l_lin 4y ago
24.
by david_l_lin 4y ago
>you will get paid SIGNIFICANTLY less than you would doing almost anything else Definitely true. >have zero autonomy Might be true? But in the right research group, this is definitely not true. I actually find that I had far more auto
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by david_l_lin 4y ago
Healthcare is notoriously slow with adoption of new technology. IMO this is because healthcare is fee-for-service, which is basically incompatible with prevention. A movement to value-based care would vastly improve adoption of preventive a
26.
by david_l_lin 4y ago
> Findings of this study suggest that the US expenditure on cancer care may not be commensurate with improved cancer outcomes. Well yeah, the cost of healthcare in the US is astronomical. https://www.healthsystemtracker.org&#x
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by david_l_lin 4y ago
Not really, we don't do tests if it won't impact treatment, and in this case there is no change in treatment (yet) based on inflammatory cytokines.
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by david_l_lin 4y ago
>Why isn’t this fact used clinically, at least for diagnosis, then? 1. Primarily because IL6 and IFNg are inflammatory cytokines that when increased can indicate any number of things, most commonly caused by infection tissue damage, or o
29.
by david_l_lin 4y ago
Cofounder at Bristle here. In short, we found that analyzing the oral microbiome from a simple at-home saliva-based test is 88.32% accurate at diagnosing gum disease (even when we ignore severity of disease). We're working on improving
30.
The oral microbiome as a predictor of gum disease(bristlehealth.com)
5 points by david_l_lin 4y ago|2 comments

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