danarlow

5 ms·

1.
by danarlow 3y ago
From the last paragraph of the paper: “The current versions of the Moderna, Pfizer-BioNTech, and Johnson & Johnson SARS-CoV-2 vaccines encode the full-length spike S protein with two mutations (spike S-2P) that stabilize the prefusion c
2.
by danarlow 3y ago
I still can’t believe that sucralose ever passed a safety trial. When has it ever been sensible to eat chlorocarbons? It’s amazing that it took this long to find some kind of genotoxic effect.
3.
by danarlow 4y ago
IMO the sugar alcohol allulose[1] has crossed the uncanny valley of sweeteners. It tastes (and cooks!) almost like sucrose and it doesn’t have a weird aftertaste. Like erythritol, it is absorbed and excreted unmodified so it is nearly acalo
4.
by danarlow 4y ago
Erythritol is absorbed by the body before it reaches the large intestine and therefore does not make you farty. (It is subsequently excreted unmodified.)
5.
by danarlow 5y ago
This. Keto makes fasting shockingly easy.
6.
by danarlow 5y ago
Keto + no dinner is extremely effective. Being in keto makes it easy to skip dinner because you never get very hungry. Skipping dinner makes it easier to be in keto because you don’t have to as strict about carbs during the rest of the day.
7.
by danarlow 5y ago
These two articles claim to debunk iron cluster-dependent magnetosensory mechanisms but not the "radical pair" mechanism described by OP.
8.
by danarlow 7y ago
Once you have a successful PCR, you have billions of copies of your target sequence that are easy to aerosolize and/or transfer by contact onto your pipettes, gloves, and other lab surfaces. When a few of these molecules find their way
9.
by danarlow 7y ago
Before you jump to conclusions, here’s a relevant quote from the article: “Although almost all coronaviruses isolated from bats have not been able to bind to the key human receptor, SHC014 is not the first that can do so. In 2013, research
10.
by danarlow 7y ago
SARS shares an enzyme that is similar enough to the HIV protease that people tried the HIV protease inhibitors on SARS and they seemed to work. This coronavirus has a very similar enzyme so it’s the same idea
11.
by danarlow 7y ago
I’d like to discuss! Email in my profile
12.
by danarlow 7y ago
This is not correct reasoning about genetics. I've seen a lot of comments with this same incorrect claim on HN recently. In a complex trait like IQ, there is no reason to believe that stacking all of the alleles that each are individua
13.
by danarlow 8y ago
Contemplate your own mortality
14.
by danarlow 9y ago
The graduate student is only getting paid $33k/yr. The university is paying for/waiving the student's $50k/yr tuition. Why should the student pay taxes on what the university is paying?
15.
by danarlow 10y ago
High ambient humidity means no net evaporation of your sweat so no cooling effect of sweating. If the ambient temperature is above body temperature and humidity is high, you won't be able to cool yourself and will quickly overheat (kee
16.
by danarlow 10y ago
There several manufacturers of YBCO wire now, e.g. http://www.superpower-inc.com/content/2g-hts-wire
17.
by danarlow 10y ago
Hey, I've done some (supervised) teaching in Culadasa's method and I've done three retreats with him. We've got a Google Hangout every Tuesday where we discuss our practice and help people out who are stuck, and I think
18.
by danarlow 10y ago
True, but it pretty definitively refutes the hypothesis that raising the minimum wage to $15 would dramatically increase unemployment in any reasonable setting. That is an important result. Now can have a discussion about the costs and bene
19.
by danarlow 10y ago
"Density Functional Theory" and "Quantum Monte Carlo", two ways of calculating electronic structures (the former tends to be more approximate and the latter tends to be more computationally expensive)
20.
by danarlow 10y ago
Electron multiplying CCD cameras can respond to single photons with > 90% quantum efficiency [1] -- that's better than rhodopsin. (I use one on a semi-daily basis.) To take advantage of that sensitivity you need to cool the sensor t
21.
by danarlow 10y ago
Yes, this reasoning is correct. Same principle applies to combination therapies for HIV, malaria, etc., where you're at risk of developing a resistant strain within the patient. Not sure why it isn't more common among cancer thera
22.
by danarlow 10y ago
ahem... just because sucralose is not super reactive does not mean that it is not harmful. some evidence suggests it can screw up your gut microbiome: http://www.nature.com/news/sugar-substitutes-linked-to-obesi...
23.
by danarlow 10y ago
Definitely can't remotely operate a 40 ton truck. Wireless network latency is a bit high even under ideal conditions, and latency spikes could easily cause disastrous accidents.
24.
by danarlow 11y ago
And why exactly should we assume the "additivity of small effects" assumption holds far from the center of the current g distribution?? Stack up enough of these variants and you're into unknown territory, including possibly i
25.
by danarlow 11y ago
Many plant-derived chemicals that are called "antioxidants" by the popular press (e.g. catechins [1], anthocyanins [2], retinoids [3], etc.) have been shown to kill some types of cancer cells in vitro and in animal models, but no
26.
by danarlow 11y ago
high current/field applications: magnetic energy storage, magnetic plasma confinement for fusion, particle accelerators, rail guns, magnetic levitation/bearings extreme sensitivity applications: portable NMR spectrometers/MRI
27.
by danarlow 11y ago
The big application for superconductors is wire, and it's much harder to compress a wire to a million atm than it is to cool it to -70 C. However, this result is important (if independently replicated) because it demonstrates that the
28.
by danarlow 12y ago
Re running your program "backwards": good luck ever figuring out if your sampling of an unknown but very complex distribution has converged :/