chenja

7 ms·

1.
Verge Genomics (YC S15) is hiring scientists and bioinformaticians(vergegenomics.com)
1 points by chenja 11y ago
2.
by chenja 11y ago
Great idea. I used to always just count down so we could start Netflix at the same point, and then sync up after a bit by pausing and restarting occasionally, this is a very elegant solution!
3.
by chenja 11y ago
very useful article! two other options I used before are just installing base R on EC2, or using this RStudio AMI I found from a Google search: http://www.louisaslett.com/RStudio_AMI/
4.
by chenja 11y ago
We are definitely not experts in regards to pharma (neither Alice or I have experience working in pharma) but our advisors include pharma consultants and senior scientists. We're constantly engaging them and meeting with pharma execs a
5.
by chenja 11y ago
Our video definitely was geared toward a lay audience, but we tried not to use buzzwords and bullshit and to explain the science in a more accessible way. I'm curious to know what what bothered you about the video and we will try to co
6.
by chenja 11y ago
We definitely didn't invent systems biology for drug discovery. But Google didn't invent search engines either, I think that we have a fresh and novel approach which is really differentiated by the details. Another thing I think i
7.
by chenja 11y ago
I am a big believer in the prion-like spread hypothesis which seems to be a common thread for neurodegenerative disease, and led a study (in press) that supports this idea in Alzheimer's disease and frontotemporal dementia. Once there
8.
by chenja 11y ago
The 1000X number should only be attached to "cheaper", and comes from in vivo and in vitro validation experiments we have done; our drug hit rate was almost 1000X higher than high-throughput screens from the literature, and our to
9.
by chenja 11y ago
YC doesn't provide advice about this in a systematic way, but we have been trying to learn how to engage the lay public mostly from talking to other YC founders. It's hard to communicate the exact details that we want to share, bu
10.
by chenja 11y ago
We have been actively validating targets, and in fact Alice's PhD work was centered on performing the in vitro and in vivo validation experiments for computational drug leads. We aren't asking for people to believe in magic, and u
11.
by chenja 11y ago
I really appreciate your feedback and of course we have studied a lot of what worked (and mostly, didn't work) in systems biology over the past decade, but the field has shifted dramatically since 2004. A lot more data is available, an
12.
by chenja 11y ago
While cheaper sequencing hasn't really produced much in the way of new treatments (yet), I disagree that it hasn't been productive or that sequence data is of low accuracy. For example, it is striking to see how relatively little