cassowary37

6 ms·

1.
How Can 50-Year-Old Chatbots Inform Clinical Applications of AI? Jama+AI Podcast(jamanetwork.com)
1 points by cassowary37 7mo ago|1 comments
2.
by cassowary37 7mo ago
ELIZA wasn't the only chatbot in the late 1960s... this JAMA+AI podcast explores how their creators took very different paths in beliefs about AI in medicine
3.
by cassowary37 1y ago
Not to take anything away from the meta-analysis and the important points in the blog post, but there's a glaring error in the abstract: "the weighted average effect sizes were as follows: social isolation odds ratio (OR) = 1.29,
4.
Machine Learning, Dataset Shift, and History in the Age of Clinical Algorithms(nejm.org)
1 points by cassowary37 3y ago|0 comments
5.
(GPT-3): Sure, but can it practice medicine?(brainconspiracy.wordpress.com)
1 points by cassowary37 6y ago|0 comments
6.
A Key Differential Diagnosis for Physicians–Major Depression or Burnout?(jamanetwork.com)
2 points by cassowary37 7y ago|0 comments
7.
by cassowary37 7y ago
sorry, intended to elaborate: When I query my health system's deidentified research patient data registry, there are multiple individuals with both a diagnosis of schizophrenia and a diagnosis of congenital (cortical) blindness. One ca
8.
by cassowary37 7y ago
Just queried my health system database and this statement as it pertains to congenital cortical blindness is factually incorrect.
9.
by cassowary37 7y ago
>"I feel like perpetuating this mindset is the ultimate sin of modern psychiatry and the entire industry of psychiatric pharmaceuticals" Hmm. Modern psychiatry is usually accused of the opposite. Also interesting that leading
10.
by cassowary37 7y ago
Ironic that folks who work in CNS drug discovery spend much of their time worrying about how to get our molecules /into/ the brain... and less energy thinking about keeping non-CNS meds out. For what it's worth, though, these
11.
by cassowary37 7y ago
the studies (which admittedly are short-term) reflect remission - i.e., resolution of symptoms. This is a critical point: the goal is resolution of symptoms, not partial improvement. The closest thing to a cure (for some people) can be cogn
12.
by cassowary37 7y ago
and HN refusal to pay attention to data when it relates to depression in 3..2..1... https://www.ncbi.nlm.nih.gov/pubmed/29477251 for moderate to severe depression, the kind most posters are talking about, they're
13.
by cassowary37 7y ago
actually that statement is itself rather presumptuous. How would you know that those of us who repeat it don't know? I can state with authority that may of us do.
14.
by cassowary37 7y ago
A colleague of mine calls suicide 'a permanent solution to a temporary problem' - not to diminish it, but to recognize that for most people the desire to die is a temporary state. Whenever depression comes up on HN (as it does wit
15.
by cassowary37 7y ago
"Obscure Newspaper Discovers 40-year-old Concept Widely Used in Medical Literature" The concept of QALY goes back to 1976[0] and is a mainstay of cost-effectiveness literature. Fair to say there has sometimes been resistance to it
16.
by cassowary37 7y ago
Fun lithium fact: while most people start the lithium story with Cade (indeed, there's a form of lithium-responsive bipolar disorder which was sometimes called Cade's disease), it was previously used by Lincoln's surgeon gene
17.
by cassowary37 7y ago
please be careful in equating the two: there are decades of studies, including large trials, demonstrating benefit for lithium. It's considered gold standard treatment for bipolar disorder even in an era where big pharma pushes hard fo
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Fujiwhara Effect(en.wikipedia.org)
1 points by cassowary37 7y ago|0 comments
19.
by cassowary37 7y ago
Here's my use case: as a scientist, I'm often in the position of needing to review multiple 20+ page grants or manuscripts, resulting in hundreds of pages at a time. I find it far easier to read closely and retain info when I can
20.
by cassowary37 7y ago
I'd be curious to hear you define biologically valid. The heritability (variance explained by inherited features) for those diagnoses ranges from 0.3-0.8 - greater than many other medical disorders - and for many of them there are iden
21.
by cassowary37 7y ago
Before everyone goes bananas citing Goodhart's law: many universities and academic medical centers in the US don't care at all about impact factor - they care about grant $$, period full stop. (They appreciate the occasional high-
22.
by cassowary37 7y ago
For everyone complaining about peer review, another alternative to open review is paid reviewers who focus on a particular topic. For example, I'm an editor at a journal where statistical reviewers are paid and evaluated, while the rem
23.
by cassowary37 7y ago
Those are all very real problems (and as you point out, they impact grant review as well). On the other hand, fully transparent peer review doesn't necessary address most of them. Reviewers who have to sign their reviews may be relucta
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by cassowary37 7y ago
nope (re being sure their ability to handle health benefits has improved)... just used them for a startup and their response to questions about integration with health benefits was essentially (3 days later) - um, we don't do that, but
25.
by cassowary37 7y ago
Psychiatrist here... bravo. The feature creep, lack of rigor, and overtly commercial nature of most CBT lite apps is precisely the reason I've been reluctant to encourage their use, vs carrying around an index card. Do one thing and do
26.
by cassowary37 8y ago
not sure why this is downvoted, it's a fair question. Conspiracy theories are fun but I think the apparent trend reflects two complementary forces: 1. More media attention to genetic testing in general (because of 23andme, other compan
27.
by cassowary37 8y ago
Exactly; I wasn't entirely kidding - steam bath would be a reasonable control. The key (beyond providing equivalent attention from study staff) is that the intervention seems like it /might/ do something. That's why I do
28.
by cassowary37 8y ago
Not randomized, not blinded. Likely to be a powerful placebo response. Awaiting the companion article, Steam bath as an adjunct treatment. Also note that the 'nih.gov' link probably unduly impacts credibility - it's just the
29.
by cassowary37 8y ago
Relevant fine print from FDA decision: i A prominent and conspicuous limiting statement that the test provides only a preliminary test result that needs to be confirmed using an independent pharmacogenetic test without
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by cassowary37 8y ago
This. Before we disappear down the HN antidepressant conspiracy rabbit hole, ever actually seen a commercial with either of those themes? You haven't - FDA would shut 'em down in a heartbeat because that's not in the label.

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