brianleb

8 ms·

1.
by brianleb 23d ago
I am skeptical of 100% anything, so did some looking: >>Mutations in PSEN1 and APP are associated with complete penetrance, meaning that all individuals who have a PSEN1 or APP mutation will develop AD if they live a normal lifespan [
2.
by brianleb 3mo ago
I share your hopeful optimism, but here's the reality of the mass-email campaigns targeting congress: [email received 6/18/26 from the office of Steve Scalise, majority leader in the house, who is one of my representatives. I
3.
by brianleb 3mo ago
As others have pointed out, too many clicks per word. I am a sucker for a 'how many words do you know' quiz so I finished anyway. Overall I'm skeptical of the classifications. In broad strokes, the early words are easier and
4.
by brianleb 3mo ago
This is a very un-nuanced and combative take on a lot of people's lives. It reminds me of it being socially acceptable for the extrovert to say to the introvert, "Why don't you talk more?" while it is not acceptable for
5.
by brianleb 4mo ago
OP did not say anything about skilled workers who make things with their hands. You are describing an artisan or craftsman, or at the very least a tradesman. The quote is talking about manufacturing labor. This is the guy on the assembly li
6.
by brianleb 4mo ago
33.1%: Nintendo's charge 29.8%: Retailer's margin 15.1%: Publisher's margin 14.8%: VAT That's... 92.8%. Developer's royalty: 4.6% "Yikes" -me, just now
7.
by brianleb 5mo ago
Ha, grew up in Harahan. When I left the LA for college, people were shocked to find out where I was from based on how I talked. I would hear areas of New England, 'no discernible accent,' and also Canadian. Apparently the Canadian
8.
by brianleb 6mo ago
I have to say I appreciate your aplomb in these responses. The whole thread is littered with shocking (and unsurprising?) tech-bro overconfidence that they can manage a situation they literally know nothing about better than someone who&#x2
9.
by brianleb 7mo ago
Similar to a sibling comment, >>the advent of chemical non-sugar sweeteners, which in recent decades are turning out to be just as harmful as sugar, only differently. requires citations. People lump sugar substitutes together as one c
10.
by brianleb 1y ago
>>a few lines of own (LLM generated) code. ... and now you've switched the attack vector to a hostile LLM.
11.
by brianleb 1y ago
Agree that it sounds 'close to correct.' I think, though, that the underlying assumption is that the old virus hangs out, forever waiting for the moment to strike. Cells senesce and die and get replaced, and the immune system is a
12.
by brianleb 2y ago
>> I had some $115k at the time in it. I'm sorry, but you are an order of magnitude out of touch with the average American consumer. Average savings balance under the age of 64 is below $73k.[1] Median savings is below $9k. Most
13.
by brianleb 2y ago
Haven't seen anyone mention this yet: there is a difference between "listed employees" vs. "full time employees" (FTEs) vs. "full time employee equivalents" (FTEEs). In this very specific case, physicians&
14.
by brianleb 2y ago
The sibling comments are very relevant, but I wanted to provide a marginally different perspective. You have to take not only what is being said, but _who is saying it_ into perspective. In this case, this is a government official speaking
15.
by brianleb 2y ago
>>"We don't say negative things about the art or the artist. Our stated goal is to collect, exhibit, and celebrate this art that would be appreciated nowhere else." Perhaps this is a 'whoosh' moment for me, bu
16.
by brianleb 2y ago
So I actually shave my beard every time I get a haircut (so, let's say every 8 weeks). What does 'recent' mean, since you have already acknowledged that temporal recency is irrelevant? When am I traveling? What's accurat
17.
by brianleb 2y ago
I'm not a cuber or a puzzle guy or a math guy, but I am curious: how do you know when it's solved? Or is this a 'whoosh' moment and I'm missing the obvious?
18.
by brianleb 2y ago
>>I wonder though what things look like with super high dimensions. You need only look to healthcare in the USA. Many, many professionals (some of which you never interact with) handing off patient cases to each other in a very carefu
19.
by brianleb 2y ago
I understand how you came to your conclusion, however what you are quoting is journalism (and it is factually incorrect). I read the actual peer reviewed article. The patients in the COVID group, _when they got COVID_ had already begun losi
20.
by brianleb 2y ago
>>how terrible injections are for patients What is this belief founded upon? Disposable syringes and detachable needles have been around for over 50 years. We had 6mm needles in the 80s. Evolution of Insulin Delivery Devices https:&#
21.
by brianleb 2y ago
GLP-1 => weight loss => decreased obesity, improved cholesterol, improved blood pressure, improved glucose control, etc. etc. => better survival rates (all causes) There is no presumed clinically relevant mechanism for GLP-1s to be
22.
by brianleb 2y ago
You're absolutely right. CEOs (and other execs) need measurable workload, just like the rest of their staff. If you're not measuring it, is the CEO landing deals, or are they just playing golf with other members of the managerial
23.
by brianleb 2y ago
My only commentary would be that these results do not read like clinical success, but rather something suggesting they should move on to phase III clinical trials. This is the only publication I found in a quick search: https://p
24.
by brianleb 2y ago
Perhaps, but the original paper (harsher sentences before lunch) does not defy "common sense." Common sense tells people that when they are hungry, they are irritable. Many people are familiar with the concept of feeling "han
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by brianleb 2y ago
Is there something about farming that precludes one from being crooked? Are there any other jobs that are above reproach?
26.
by brianleb 2y ago
Probably referring to: https://phys.org/news/2010-12-air-playstation-3s-supercomput... >>About the 33rd largest supercomputer in the world right now is the US Air Force Research Laboratory's (AFRL) newest sy
27.
by brianleb 2y ago
A super majority is a specified proportion that is in excess of a simple majority (e.g., where a simple majority would be 51%, a super majority might be defined as 60%). Per your link (which is admittedly interesting), military/defense
28.
by brianleb 2y ago
About a year ago, the New Orleans Sewerage and Water Board was found to have a "secret sex room". https://veritenews.org/2023/06/26/payroll-fraud-and-a-secret...
29.
by brianleb 2y ago
Actually, I believe what you want is 3mm, which I believe they use in accounting. Lowercase m in this instance would stand for milli-, as in thousand. So 3mm would be 3 thousand thousand. 3M is technically correct, though confusing in this
30.
by brianleb 3y ago
To chime in with the others, my Chase card offers this service automatically as well. I think most major credit card companies are starting to offer these services because they want a piece of the pie that companies like Intuit (through Min

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