blithedale

5 ms·

1.
by blithedale 6y ago
Truvada is PREP. PRE exposure prophylaxis. PEP =/= PREP. PEP is after the fact treatment, there's more than just Truvada in that protocol. PEP is typically much harder on the body than PREP. Most every gay man I know takes PREP
2.
Effect of Vitamin D3 Supplementation vs. Placebo in Patients with Severe COVID19 [pdf](medrxiv.org)
3 points by blithedale 6y ago|2 comments
3.
by blithedale 6y ago
Findings: In this double-blind, randomized, placebo-controlled trial involving 240 hospitalized patients with severe COVID-19, a single dose of 200,000 IU of vitamin D3 supplementation was safe and effective in increasing 25-hydroxyvitamin
4.
by blithedale 6y ago
Thanks for clarifying comments here, much appreciated. I have to think my initial comment was overly harsh as well, given Supplement 3. I think all I can say is that it may be possible for this issue to affect their data once they have OS s
5.
by blithedale 6y ago
I'm not convinced the 2/3 dropout rate of the FMD didn't simply select for people with less aggressive tumors, given that the Intention-To-Treat analysis found no difference in response rate, and that this paper is telling a
6.
by blithedale 6y ago
Good stuff. Also of note is tumor heterogenity. Not only are cancers different between cell origin and across different patients, cancer is not one uniform genetic entity even inside a single person. Why? The cancer's ability to repai
7.
by blithedale 6y ago
Their "better response rate" touted at the top ignores the 2/3 of women who couldn't carry out the assigned FMD. When you fold back in those 2/3 of people on that arm, the response rate is the same: "The o
8.
by blithedale 6y ago
This is like making people with cancer do an Ironman triathalon. People about to enter hospice and pass on in a few weeks are gonna be way less able to complete it than someone who has months left to live. But all you've done is strati
9.
by blithedale 6y ago
A lot of people might think "Ah, well, fasting is clearly effective for the 1/3 that are able to carry it out, just gotta make sure you have the willpower to be the 1/3." But hold on. Slow down. There's a good cha
10.
by blithedale 6y ago
ARGH. ARGH ARGH ARGH. Almost no one reads these papers when stuff like this gets posted on HN. And there is shameful statistical fuckery afoot in this paper. People are only repeating the hype statistics at the top of the paper. Their &qu
11.
by blithedale 6y ago
Except the dosing in this study is a massive supra-physiological bolus that's something like 50x the daily RDV.
12.
by blithedale 6y ago
Welcome to every Vitamin D study done ever. I follow some PHD/RD combination researchers on Twitter and they all get together each time one of these studies is done and bang their heads against a wall.
13.
by blithedale 6y ago
Thank you thank you thank you. There is a craze for popping Vitamin D related to the raft of observational studies, here... so many of which never find a causal link. Take my own particular condition: an inherited vascular dysplasia which c
14.
by blithedale 6y ago
There are seven results for American trials found on clinicaltrials.gov for Condition= "COIVD19" and Drug = "VitaminD" run by institutions like Harvard/MGH, Brigham, UNC, Arizona State University, etc. https:/
15.
by blithedale 6y ago
The worst case scenario isn't 'healthier bones'. It's kidney failure - https://www.cmaj.ca/content/191/14/E390 Or fatal hypercalcemia - https://link.springer.com/article&#
16.
by blithedale 7y ago
I suggest folks read the cited research. It's eye-opening here, in a way that's very irritiating. This does not seem like particularly good science journalism. Because of the road rage story in the lede, a whole lot of people ar
17.
by blithedale 7y ago
You're a cardiology fellow, so you're likely much better versed in this than me, but take a look at the paper cited here: Sure looks like they were doing multiple comparisons until they found a happenstance significant subgroup.