blaurenceclark

5 ms·

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by blaurenceclark 7y ago
Love this!
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Show HN: Game of Shows – Fantasy Sports Meets TV Shows(gameofshows.co)
5 points by blaurenceclark 7y ago|1 comments
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by blaurenceclark 9y ago
The fully explored answer to that is an article (or book) in and of itself, I can't cover every single outcome but highlight some prominent ones in a 2000 word article.
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by blaurenceclark 9y ago
I 100% disagree with everything you say here. For one, that is not a PR disaster as the headline you're using is one no one would ever use as it is insensitive. In fact what would happen is "New cancer treatment found to be more e
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by blaurenceclark 9y ago
Well you’d have to do basic research, come up with a hypothesis, then run a clinical trial to test that hypothesis. And hopefully find useful information although clinical trials do fail.
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by blaurenceclark 9y ago
There is actually a push here (ignoring mandated public funded trials) because the Minority populations are becoming large enough that if a diabetes drug that was better in black people existed there’s a massive underserved customer base. F
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by blaurenceclark 9y ago
We don’t because no one has run a clinical trial to find out why :(
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by blaurenceclark 9y ago
That only happens for certain drugs, typically treatment naive diabetes, IBD and other chronic disease patients where in the US there’s a standard treatment the patients receive right away so they have to go overseas to find untreated patie
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by blaurenceclark 9y ago
Totally agree, "bucketing" is certainly hard, but to define every possible bucket would have me writing an entire book. This piece is meant to get the discussion started and open peoples eyes to the existing problem and consciousl
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by blaurenceclark 9y ago
I could write a whole other article on this as well. The pregnant women part actually fits extremely well in this context even more so, they aren't neglected, they are specifically left out because researchers don't want to have t
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by blaurenceclark 9y ago
That's 100% true, I'm not saying we have to create a new drug, but define what is the best treatments available, as well as take that into account when the treatments are being made. Especially as there become more black people if
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by blaurenceclark 9y ago
More minority volunteers, and having clinical trials where minorities go to for care. Great example is most of the well funded academic institutions that run research are in affluent, mostly white neighborhoods, so if a (for assumption) poo
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by blaurenceclark 9y ago
* All Minorities, not one minority, and technically I believe all funded research should reflect the populations that exist rather than focusing on one, and take the various genetic backgrounds into account when developing treatments.
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by blaurenceclark 9y ago
If I were to cover every one of the points you called out in detail (which are all valid) I'd end up with an entire book haha.
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by blaurenceclark 9y ago
Thank you!!
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by blaurenceclark 9y ago
Your assumption seemed to be that genetics didn't tie to ethnicity, which it is hence I restated it.
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by blaurenceclark 9y ago
110% agree. The government has actually had a mandate out for publicly funded research since 1993, but only have enforcement rules been enacted and we have yet to see if they will be followed through on. For research done by private institu
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by blaurenceclark 9y ago
It would mean that if a drug was inefficient on an African American of Zimbabwe descent, the same drug would be unlikely to be efficient on the black people Zimbabwe. There are measurable genetic traits these can be attributed to, although
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by blaurenceclark 9y ago
Honestly I have no idea which would have a better outcome, but I know both would have a great impact. My assumption would be the second one if I had to pick though, for example as an African American I have a sickle-cell trait and thus I sh
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by blaurenceclark 9y ago
Attacks from everywhere haha. I'll keep educating anyone I can on this until the day I die!
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by blaurenceclark 9y ago
Your assumption in #2 is incorrect. What actually happens often is the doctor doesn't know what to prescribe the patient and the patients quality of life suffers. As well as stated in my article, one of those alternative treatments &qu
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by blaurenceclark 9y ago
I'm going to quote what someone said below because this is blatantly false "This is not only false, but dangerously false. We are in the process of discovering that certain classes of popularly-prescribed drugs (eg ACE inhibitors
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by blaurenceclark 9y ago
You completely missed the point. I specifically put statistics in my article to refute this. In many clinical trials African Americans that contract various conditions at the same rate or higher than White Americans represent only 1% of the
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by blaurenceclark 9y ago
It is an indirect correlation. BMI is a factor related to the likelihood of having diabetes, and what's considered a safe range for white people is an unsafe range for Asians. Thus if you have a white person at a 25 BMI and an Asian pe
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by blaurenceclark 9y ago
Actually the AI portion of our product is mostly for making clinical trial recruitment more efficient, although we consciously add demographic tweaks to our algorithms to help identify specific patient populations that many researchers simp
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by blaurenceclark 9y ago
When you're main concern is "What is a minority" rather than "minorities are dying" that is very indicative of the problem still existing
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by blaurenceclark 9y ago
Actually environmental factors are a big portion of clinical research. Most people think of just the precision medicine approach, but often taking in environmental factors and developing treatment plans that take that into account are a big
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by blaurenceclark 9y ago
Then why is asthma medication less effective on Latino's and African Americans? And why did my friend have to visit 5 doctors and it wasn't until he found the Black doctor that his skin condition (which is common to only African A
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by blaurenceclark 9y ago
There is a much longer answer to that question. SK and Japan only make up 5% of the asian population, many parts of asia are not well tested for these drugs. We're actually in the process of working with a large pharmaceutical company
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by blaurenceclark 9y ago
No single group that is currently a "minority" would overtake the white population, therefore every other population in the US would still be considered a Minority until there is an equal or more number of a single minority than t

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