apathy

5 ms·

1.
by apathy 7y ago
You could use transmissible preleukemia (eg CHIP in allo transplants) as an example if you wished. Direct unassisted clonal transmission in humans seems likely but, as you noted, it hasn’t been documented to the extent that Tasmanian Devil
2.
by apathy 7y ago
HTLV, EBV, HPV you better believe we have! It’s just rare (thank goodness).
3.
by apathy 7y ago
Indeed, this is why hydrogen sulfide is toxic in smallish doses
4.
by apathy 7y ago
Independent. The 60th vote was an independent who endorsed John McCain in preference to Obama. How can one person manage to be so consistently incorrect?
5.
by apathy 7y ago
Remind us who tanked the public option in the ACA? Hint: he was Al Gore’s running mate a decade prior. And he was never a republican.
6.
by apathy 7y ago
China tends to buy light crude instead of light sweet crude, hence the oil and derived fuels have more sulfur than is typical for European or American vehicles, industry, etc. This is something of a problem when a country with as many peopl
7.
by apathy 7y ago
Oh good grief you’re right. This is doubly sad because using an ensemble metric for per-author eigenfactor seems like it would be tractable. Carl Bergstrom is a smart guy so I suppose the practical implementation of the above must have some
8.
by apathy 7y ago
Aka eigenfactor
9.
by apathy 7y ago
As a machine learning / probabilistic programming friend put it, (journal) peer review is boosting with three weak learners. Better than nothing, but very far from ironclad. Only replication really verifies scientific findings. Everyth
10.
by apathy 7y ago
Timeless wisdom.
11.
by apathy 7y ago
At least for lineage switching malignancies (5yo female was MLLr), I’m not sure anything other than synthetic lethal attacks on the clonal driver will help. MLL rearrangements in young children have a particularly vile habit of swapping cel
12.
by apathy 7y ago
Not mentioned here: the same results can in many cases be had from BiTEs at lower cost and without having to ship leukapheresis samples to the US in liquid nitrogen Having seen both ALL and AML patients relapsing through CAR-T, I don’t thin
13.
by apathy 7y ago
I bought one of these to teach a one-shot class on experimental design and statistics. To say it served the purpose would be an understatement. We blew through the CLT and derivation of statistical power in 10 minutes, leaving the other 110
14.
by apathy 7y ago
woo
15.
by apathy 7y ago
This paper is a PR gold mine but a methodological disaster, which is par for the course in "EWAS" (epigenome-wide association studies). At one point I had to remind a coauthor that pointing out structural problems in fashionable s
16.
by apathy 7y ago
Posts like yours are the reason I come here. Great stuff. And yes glycoPTMs are insane.
17.
by apathy 7y ago
sci-hub.tw does
18.
by apathy 7y ago
Dubious — cellular senescence (whether proliferation- or oncogene-induced) is the usual failsafe for avoiding proliferation of damaged cells. It relies heavily upon TP53, RB1, and CDKN2A, all of which are routinely deleted in tumors. When a
19.
by apathy 7y ago
Also worth noting: this is further evidence that cancer, like many other diseases, is in part an immune disease. When central tolerance is too lax, tumor cells can more easily survive a trip through the bloodstream to seed metastasis (the e
20.
by apathy 7y ago
This is accurate in every field I’ve worked in (synthetic organic chemistry, comp chem, statistics, genetics, clinical trials). The top glam journals have an additional layer of politics. It’s the worst system aside from all the others that
21.
by apathy 7y ago
I download the illustrations (duh?). That’s the value. I don’t actually care about the service per se. Once the illustrations are in the paper/talk, the value has been realized, for my lab. Nothing in this world lasts forever. I’m ok w
22.
by apathy 7y ago
The phrase you may be looking for is “vertical market” and it’s a phrase that makes MBA types salivate. An underserved and overcapitalized vertical market can support amazing profits.
23.
by apathy 7y ago
This. I sent them some vector art that was already better than 99.9% of figures in quality review articles, and they made it better. Nobody I know that has signed up for this service has regretted it for one second. (Contrast with Dropbox
24.
by apathy 7y ago
Because these teams have never used (eg) google slides to put together a presentation from 3 different continents I have, and I’ll never go back to PowerPoint. Not coincidentally, my lab uses biorender all the time and it saves us an absurd
25.
by apathy 7y ago
JFC it’s a literal adaptimmune ad. “At Megaconglomco Inc, we use our patented pan-galactic gargleblaster fragments...” Here I thought we were going to see something like Steve Forman’s work on CAR-T in glioblastoma, or allo-NK, or diet-base
26.
by apathy 7y ago
Greg Lowe’s cams predated friends by about 3-4 years
27.
by apathy 7y ago
Because there aren’t any systematic perverse incentives baked into US healthcare or anything. Like, say, many if not most preventive measures being unreimbursible while treatment (especially Stone Age chemo protocols) are reimbursed at prof
28.
by apathy 7y ago
Yes! This seems to be the turd in the punch bowl. If you can find a good property manager and a good tenant, it’s not bad. Bad either can get ugly quickly (in CA).
29.
by apathy 7y ago
I thought it would tank in 2001, then again in 2008, and yet again in the current bubble. It seems like the environs get hit, but SF and SV itself seem to be immune. Los Angeles (where we were) is a bit more volatile (ie it actually goes do
30.
by apathy 7y ago
Have you sold any of the managed properties? That seems to be where problems arise. A fellow landlord friend ended up having to dump his property manager and bring in a REA who whipped the place into shape for sale. 8% is not bad if the goa

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