a_bonobo

6 ms·

1.
by a_bonobo 8d ago
This ties back into AI, too, right? I always like to bring up how many decades of research, how many hundreds of years of entire PhD-theses, how many sleepless nights were used up to generate all the protein structure data that made up the
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by a_bonobo 10d ago
Did you see that Andrew Gelman and others just published Bayesian Workflows? https://avehtari.github.io/Bayesian-Workflow/ It sounds similar to what you're after, away from describing the logic of models and the m
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by a_bonobo 15d ago
Sure! I was building a workflow that assesses human gene model accuracy. Which part is supported by what evidence? Important for drug development; if we want to change $THING it better exist in the first place. I came up with a set of rules
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by a_bonobo 16d ago
As an ex-academic (not mathematician), this really resonates. Every generation of researchers has to outperform the researcher generation before them - there are fully tenured profs out there who, with their track record, wouldn't get
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by a_bonobo 17d ago
You may be thinking of one of the poems of Christian Morgenstern? He used many tricks of formatting for jokes, famous example that fits with yours is The Funnels https://www.babelmatrix.org/works/de/Morgenstern%2C_
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by a_bonobo 17d ago
The German is more crass: Hurenkind and Schusterjunge, translates to 'child of a whore' and 'shoemaker boy'. The child of a whore does not know where it comes from (who is their father), the short final line - the shoema
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by a_bonobo 21d ago
Australia too - however, to get a renewal all you need is an online connection and a credit card, the renewal (at least for me!) goes through automatically. (Notwithstanding that Australia just increased the PR-renewal cost from ~400-500 to
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by a_bonobo 24d ago
I've spent SO MUCH TIME in my life trying to get laboratory machinery, usually only ten of them in the world, to spit out their data nicely. They have UIs but usually god-awful, and all data is hidden away somewhere (they're writt
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by a_bonobo 1mo ago
Security/compliance have the external hammer: if they fail, your org will have to pay fines and someone may end up being criminally liable (depends on country). The ethics department; if they fail, there may be some negative journalism
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by a_bonobo 1mo ago
>On my visits to the Bay Area, I would ask AI researchers or interns why they are doing their current research or projects, when in a year or three agentic LLMs could probably do them; This is such a weird point to make that doesn't
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by a_bonobo 2mo ago
It is ideology. It's very obvious the current US government thinks that universities are a waste of money, and that industry is where everything happens. This industry PhD shuffles money from the university's pockets into industry
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by a_bonobo 2mo ago
Depends in which country you are! IT advice is handled by your regular IT service companies. AI assistance is going gangbusters, as evidenced by Anthropic hiring biologists left and right, places like Isomorphic Labs and Xaira have huge val
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by a_bonobo 2mo ago
Yes, getting the drug into the right cell or tissue is still largely unsolved (kidney is easier than brain, of course). But the investors we talk with have dropped all interest in gene editing, too risky. RNA-based technologies are great, t
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by a_bonobo 2mo ago
I actually do this for a living within pharma now! There's a TON of work that goes into drug discovery before we even call it a program. The odds of success are low, so we put in months of work evaluating a candidate before even have a
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by a_bonobo 2mo ago
Doesn't that happen with any first-year psychology or med-student, too? You have some basic knowledge of what could happen, which therefore means that it does happen, right now, here. It normally goes away with more experience and
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by a_bonobo 2mo ago
I used to co-supervise a PhD student who suffered from severe anxiety, she was good but her anxiety stood in her way almost all of the time. You could see that she used up 3/4 of her brain just on being anxious, there wasn't much
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by a_bonobo 2mo ago
I mentioned Densha de GO above, they have a designated controller like that for the Nintendo Switch too :)
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by a_bonobo 2mo ago
It wouldn't surprise me if Japan has its own market for train assets. There's a big community of train simulators! Go to the Kyoto or Tokyo train museums, they have dozens where you step into a replica of a train cab and then driv
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by a_bonobo 2mo ago
Yes, this has been my experience in the Australian academic system as well: everything is broken and nobody with the power to change it, cares. China seems to make some strides for their own academics, thinking loudly about moving away from
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by a_bonobo 2mo ago
They are pretty much the same, yes! Those eDNA providers usually use a wider range of primers (12S, 16S, COI etc.) to capture a range of invertebrates, vertebrates, plants etc. For Covid, since it's only that one virus, you can target
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by a_bonobo 2mo ago
https://www.envirodna.com/ https://www.naturemetrics.com/species-detection https://www.ednacollab.org/industry/ https://wilderlab.co/ These companies focus on environm
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by a_bonobo 3mo ago
Why would I pay 10 dollars per month for music I can AI-generate myself for free?
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by a_bonobo 3mo ago
Good move, it's crazy how many scam calls and SMS I receive in Australia. In fact, if I get an SMS or a call, I just assume it's a scam.
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by a_bonobo 3mo ago
Many billionaires are starting up ocean expedition places, surely they'll want IT. Off the top of my head I can think of OceanX (Ray Dalio), Inkfish (Gabe Newell), RevOcean (Kjell Inge Rokke out of Norway). They're all building or
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by a_bonobo 3mo ago
Ah, personas! https://bufferbuffer.com/using-personas-in-technical-writing... >In user experience (UX) design, personas are fictional characters representing the different types of users who might use a product or servic
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by a_bonobo 3mo ago
KPGM et al. are used as political ammo to push through internal changes. Those in power rely on consultancies underlying their decisions (painful redundancies, firings, etc.). Acknowledging that the arguments for these painful decisions was
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by a_bonobo 3mo ago
Oh no, that's just coincidence. In proteomics world, a peptide is just a short protein (<50 amino-acids?).
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by a_bonobo 3mo ago
I'd go even further: what happens in biology is antithetical to the way software people think. The HN/YC crowd generally has software brain: https://www.theverge.com/podcast/917029/software-brain-ai-ba...
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by a_bonobo 3mo ago
The accompanying preprint is interesting: https://www.biorxiv.org/content/10.64898/2026.06.03.729735v1 Modeling protein-protein binding is still a massively unsolved problem, mainly because we don't really ha
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by a_bonobo 3mo ago
At my previous work, I was collating somewhat random unconfirmed animal sightings. I also had a separate database of animal occurrence probabilities (species distribution maps). I'm not a statistician but that sounded like a clear job

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