blockcipher

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121.
by __blockcipher__ 5y ago
Thanks. I'm glad to know it's not what it appeared at first glance. And apologies if I drew any unwanted attention to your account.
122.
by __blockcipher__ 5y ago
They should disclose that, though. Otherwise the feedback is indistinguishable from astroturfing. Pretty much everything about this guy rubs me the wrong way. The usual cheesy testimonials / vague promises of content which never really
123.
by __blockcipher__ 5y ago
This might just be paranoia but a couple of the early comments on this thread feel very astro-turfy. For example: https://news.ycombinator.com/threads?id=vich (hasn't commented since aug 2020) https://news.y
124.
by __blockcipher__ 5y ago
> You'll have almost no reports of "systemic circulating virus" load, because there's not really an accepted definition for how this measurement would be taken. Wait, what? This seems completely at odds with the liter
125.
by __blockcipher__ 5y ago
Well it seems to follow pretty naturally that if you think that division is a problem, then being aware of how your attitude is the definition of division seems pretty important.
126.
by __blockcipher__ 5y ago
> Imagine if someone said “I want to have a baby but absolutely no waking up at 2AM”, you would be laughed at. Okay, now imagine that I have a baby. I offer you a .0001% ownership in the baby, and you have to get (potentially, but often
127.
by __blockcipher__ 5y ago
Agreed. There are way too many people in our industry who accept being treated like utter garbage, and that's a problem, but we should also be clear that at the end of the day people do need to learn to stand up to themselves and not t
128.
by __blockcipher__ 5y ago
> But if you're paid 150, 200k or more? I hope you're not expecting 9-5. Speak for yourself, but I would never accept a $150k a year gig that expected me to be on-call, say, 1 week out of every 6. $150k is absolutely a "9-
129.
by __blockcipher__ 5y ago
The short answer is "yes". The long answer is "that's a philosophical question". Downregulation is a natural homeostatic mechanism that happens with almost everything. Any time a certain receptor gets stimulated abo
130.
by __blockcipher__ 5y ago
I don't know precisely but I remember it's something like bubbling d-tartaric acid through the racemic methamphetamine mixture to separate out the d-methamphetamine. The overwhelming majority of US meth is cartel-sourced. They hav
131.
by __blockcipher__ 5y ago
> but I don't think it's anything I'd go for if i were only 10% as intense and came with all the twitchy/tweaker effects. The jaw clenching I got from MDMA was more than enough of that. While we don't know the ex
132.
by __blockcipher__ 5y ago
> Your drug use can't put me in the ICU. Take this to its logical conclusion, please. It's the big bang's fault!
133.
by __blockcipher__ 5y ago
This is off the top of my head, so no citations, but d-methamphetamine is something like 30% more potent than d-amphetamine. The fact you're taking Adderall makes the comparison more complicated though because you're not taking d-
134.
by __blockcipher__ 5y ago
Thanks so much for your correction/insight here. My chemistry knowledge is pretty weak - and extra rusty - so that was very helpful.
135.
by __blockcipher__ 5y ago
Yeah that and the general inclusion of fent hotspots in Heroin and the like is why overdoes have skyrocketed over the last 5+ years. And then COVID [lockdowns] in my opinion cranked the growth in ODs even higher. It was growing at something
136.
by __blockcipher__ 5y ago
Not that I know of. One of the side effects of amphetamine usage is compulsively researching details about amphetamine, so that’s where my knowledge comes from :) Certainly need to read some of the research literature and places like /
137.
by __blockcipher__ 5y ago
Meth doesn't have to be smoked, you can just eat the crystals orally, but meth abusers uusally don't do that because it's not nearly as fun. The pills they're referring to, 30 M ( https://www.drugs.com/imp
138.
by __blockcipher__ 5y ago
> I'm not a chemist, but would we expect both isomers to break down under heat the same way? Or is the l-meth potentially being converted to something different than d-meth when smoked? Methamphetamine is very, very stable. It stay
139.
by __blockcipher__ 5y ago
On MacOS I use an app called Amphetamine to prevent my computer from sleeping. I got a real kick out of that. I got a further kick when I learned that Amphetamine was the successor to the earlier version, which was called Caffeine.
140.
by __blockcipher__ 5y ago
Sorry for the confusing terminology. "Peripheral stimulation" means unwanted stimulation of the body itself, such as suppressed appetite, general jitteriness, and the like. Whereas the cerebral effects are the actual cognitive eff
141.
by __blockcipher__ 5y ago
Totally agreed. Expanding a bit on some of the stuff you mentioned: Vyvanse hits C_max around 3 to 3.5 hours. But you'll hit the maximum "acceleration" (as opposed to "velocity") around 1-2 hours like you said. Fun
142.
by __blockcipher__ 5y ago
You're right on most of that but off on some details. Only Vyvanse is anti-abuse, because the dextroamphatamine is bound to a lysine molecule. The body must cleave the lysine before it becomes active so snorting it doesn't give th
143.
by __blockcipher__ 5y ago
> Meth in a bottle is called Adderral. No, it's not. Please stop spreading this age-old myth*. You can literally buy prescription meth in a bottle, and it's called Desoxyn. Adderall is extremely similar, because amphetamine is
144.
by __blockcipher__ 5y ago
> I also recall the show depicting meth users having all those problems - Jesse is paranoid the missionaries are bikers, there's that guy digging a hole in his front yard, Spooe and his head, etc > Seems like the drug was fucking
145.
by __blockcipher__ 5y ago
Yeah it's all very straightforward when you look at usage patterns. Often meth abusers will smoke multiple points across a day (a point = 100mg). As a result they stay awake for days straight, don't eat, and often will engage in e
146.
by __blockcipher__ 5y ago
A lot of it is statistical fuckery. The set of people hospitalized who are unvaccinated is not the same as the set of unvaccinated people who end up getting hospitalized. But some of it is certainly true. Vaccination makes a very significan
147.
by __blockcipher__ 5y ago
Oh wow. I saw the title and was ready to explain how the cartels had perfected p2p synths such that they yield almost exclusively pure d-methamphetamine, but before explaining that I was going to need to explain the general concept of chira
148.
by __blockcipher__ 5y ago
That's a fine argument, but I've never seen a proper quantitative assessement of the risk of hospital over-run with respect to vaccination rates (or in general, frankly). The vast majority of COVID infections are mild or completel
149.
by __blockcipher__ 5y ago
So do the COVID vaccine mandates, frankly. Relatively short lived (~months) protection against infection, which itself comes at the cost of encouraging vaccine escape variants to become the dominant strain. Furthermore while protection agai
150.
by __blockcipher__ 5y ago
> This isn't AWS and Elasticsearch Is your implication that there is something wrong about AWS running OSI-licensed open source software as a service? In general your comment doesn't make much sense to me. First of all it assum

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