JunkDNA

6 ms·

1.
by JunkDNA 1y ago
I have fond memories of playing the original Falcon on my Amiga 500. It felt like magic after years of playing F15 Strike Eagle on the Apple IIc. Hearing real sound effects kicking in the afterburner and getting too close to the ground (&qu
2.
by JunkDNA 1y ago
This article isn’t particularly helpful. It focuses on a ton of specific OpenAI business decisions that aren’t necessarily generalizable to the rest of the industry. OpenAI itself might be out over its skis, but what I’m asking about is the
3.
by JunkDNA 1y ago
I keep seeing this charge that AI companies have an “Uber problem” meaning the business is heavily subsidized by VC. Is there any analysis that has been done that explains how this breaks down (training vs inference and what current pricing
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by JunkDNA 4y ago
Exactly. If you are an L7 and making an average L7 salary, nobody should have to squint and tie themselves in knots to figure out the connection between your contribution and your employer’s revenue. You are a Ferrari that is purchased new
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by JunkDNA 5y ago
They’re not using mRNA. They are using a viral vector that contains DNA.
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by JunkDNA 5y ago
I’m not sure if it’s a false memory or not but I believe there was a pretty cool demo that used this as the background music as well.
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by JunkDNA 5y ago
Bingo. I wish I could upvote this comment more. All the geeks get distracted by words like “cloud” or “virtual” and forget that all this stuff we depend on has a physical presence at some point in the real world. That physical presence nece
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by JunkDNA 5y ago
I highly recommend the piece by Derek Lowe down thread, but the tldr is basically that researchers have believed amyloid plaques cause the symptoms of Alzheimer's and so the theory is that if you eliminate them, you can treat the disea
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by JunkDNA 5y ago
I was on one of the teams that refuted the claims of horizontal gene transfer in the original human genome paper. The bar for establishing a true case of horizontal transfer in vertebrates is high. It’s really improbable given the required
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by JunkDNA 6y ago
In business, many times the lack of any decision (good or bad) wastes valuable time. Especially for leaders, unblocking teams to move forward has real value beyond whether or not the actual decision is optimal. A great many decisions are re
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by JunkDNA 6y ago
USB remains the only connector I use where I routinely get the orientation wrong 3 times.
12.
by JunkDNA 6y ago
It’s not a vaccine if you don’t have efficacy data. You can go snort all kinds of peptides all day long, that doesn’t mean you’re going to actually have something useful happen. Do you know why we’ve developed all these complex rules about
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by JunkDNA 6y ago
Speculation on the other thread is too many people have flagged the other post.
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by JunkDNA 6y ago
My daughter now 10 was diagnosed with a severe egg allergy around the time she turned 1. We aren't vegans and I love all kinds of things with egg (including home made pasta). We tried so many egg replacers and were just not that impres
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by JunkDNA 6y ago
I would argue what makes the world a better place is ensuring companies have to innovate on their own. That’s what leads to breakthroughs and new things. Constraints often breed innovation. What is the incentive to sink billions into R&
16.
by JunkDNA 6y ago
There is sometimes specific information about the actual manufacturing process or synthesis that companies provide. Given that this is an entirely new vaccine technology that has never been used before, there was probably quite a bit of con
17.
by JunkDNA 6y ago
It was a murky situation, but LYMErix comes to mind: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2870557/
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by JunkDNA 6y ago
Syapse here! We are a real-world data company working across life science (pharma), hospitals, and with the FDA. We want to use real-world evidence to improve the outcomes of cancer patients. When many think of Health IT, they think primari
19.
by JunkDNA 6y ago
It didn't come across in my post in retrospect, but just want to say clearly I love this idea and the ambitious nature of it. I think when someone works in drug discovery, it's hard to escape this feeling that there has to be a be
20.
by JunkDNA 6y ago
A few random thoughts I'm curious about (full disclosure: I worked in anti-infectives R&D as a bioinformatician early in my career for a major pharma) 1) One big challenge in synthesis is ensuring compound purity. Even when I was w
21.
by JunkDNA 6y ago
I'm glad you posted this because when I saw the headline to this article my first reaction was, "Wait, this isn't news to me, I fired a ton of these things in that video game". Then I thought, "No, probably a false
22.
by JunkDNA 6y ago
Spending more on marketing than R&D has been a favorite thing to zero in on but it's not really a useful metric. See here: https://blogs.sciencemag.org/pipeline/archives/2013/05/23/an...
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by JunkDNA 6y ago
There is a fundamental difference between a CEO at company operating at GSK's scale and for example, a few hundred person startup biotech. It's a mistake that engineers and domain experts make to assume the CEO always needs to be
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by JunkDNA 7y ago
Have you ever been in an executive leadership position that required you to make tough decisions? As someone who recently has entered this realm, let me tell you: most of the decisions in front of you are essentially choices between a whole
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by JunkDNA 7y ago
Back in the late 90’s and early 00’s, there were a ton of cpu platforms around: SGI MIPS, DEC Alpha’s, Intel, Sun SPARC, etc... while I will admit it was a colossal pain working somewhere that had all of those, it was often possible to reco
26.
by JunkDNA 7y ago
Thank you for this write-up. I recently (last ~3 weeks) started working with a coach for the very first time in my career. I think I've been nibbling around the edges of a lot of what you address directly here. What I'm only now s
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by JunkDNA 7y ago
I believe many (most?) US hospitals have switched to secure paging services delivered via smartphone. HIPAA pretty much requires it.
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by JunkDNA 7y ago
Do you have any support for the claims you just made? Synthetically made DNA is not going to give people viruses or cancer when physically applied. It’s hard for me to imagine it doing much of anything even if inhaled/consumed. Similar
29.
by JunkDNA 7y ago
The discipline of science (and its sibling mathematics) has been one of the great achievements of human civilization. It has been so astonishingly successful, we can’t even fathom there being any phenomena beyond its reach, given enough tim
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by JunkDNA 8y ago
I’m not arguing that there aren’t people who have legit reasons to want to pay less for email services. I’m arguing that if the OP wants to run a profitable business , targeting that particular demographic is unwise. Hobbyist/tinkerer

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