CreRecombinase

9 ms·

1.
by CreRecombinase 4mo ago
Why not just use a dictionary, or why not just leave the type unannotated? If you really can't (or don't want to) say anything about the type, then don't. Python is dynamically typed!
2.
by CreRecombinase 9mo ago
Have you tried this yet? Looks like it uses the ms graph API https://github.com/jgunthorpe/cloud_mdir_sync
3.
by CreRecombinase 1y ago
I turned this on and for most "general" use cases I found it useful, I also observed a downward biased in a family of "quantatitative estimation" tasks, so just remember when you have this kind of stuff turned on (always
4.
by CreRecombinase 1y ago
It’s kind of wild how much work really smart people will do to get python to act like Fortran. This is why R is such a great language IMO. Get your data read and arrays in order in dynamic, scheme-like language, then just switch to Fortran
5.
by CreRecombinase 1y ago
The comment you linked is a response to my comment where I tried (and failed) to articulate the world in which R is situated. I finally "RTFA" and the benchmark I think perfectly deomonstrates why conversations about R tend not to
6.
by CreRecombinase 2y ago
Every two weeks or so I peruse github looking for something like this and I have to say this looks really promising. In statistical genetics we make really big scatterplots called Manhattan plots https://en.wikipedia.org/wik
7.
by CreRecombinase 2y ago
R was heavily inspired by scheme, and I think that's a big part of why it's so popular in the scientific community (it's a great language for authoring DSLs). In fact, DSLs are so good in R that lots of midwit CS bros love
8.
by CreRecombinase 2y ago
This is what's so brilliant about the Microsoft "partnership". OpenAI gets the Microsoft enterprise legitimacy, meanwhile Microsoft can build interfaces on top of ChatGPT that they can swap out later for whatever they want w
9.
by CreRecombinase 3y ago
QR decomposition isn’t in BLAS, you’re probably thinking of LAPACK.
10.
by CreRecombinase 3y ago
No. OTOF is the gene symbol. Referring to the gene as otoferlin is perfectly legitimate
11.
by CreRecombinase 3y ago
That’s certainly not true in scientific computing. For us, dynamic is very much the exception rather than the rule.
12.
by CreRecombinase 3y ago
How might one go about making the nuclear family a universal?
13.
by CreRecombinase 3y ago
That’s absolutely not true about Microsoft. They’re very clear about how they use your data. If they’re mining data in secret against their own terms that’s felonious criminal behavior.
14.
by CreRecombinase 3y ago
I think what it comes down to is that it's very difficult to divorce modeling from inference.
15.
by CreRecombinase 3y ago
It's absolutely not "on the way out". Lots of very slow moving, very deep pocketed organizations working on very long time horizons are heavily invested in HDF5. The same can't be said for any of the flavor-of-the-week
16.
by CreRecombinase 3y ago
Does pigz offer any advantages over bgzip?
17.
by CreRecombinase 4y ago
I spend most of my time in the parallel universe that is scientific computing/HPC. In this alternate reality SQL (not to mention databases) never really took off. Instead of scalable, performant databases, we have only the parallel f
18.
by CreRecombinase 4y ago
How often do you have markup in the middle of a phrase you're searching for? It seems to me like if that's really important to you, then just don't use a lot of markup?
19.
by CreRecombinase 4y ago
I've never seen a 15x difference in density between gzip and zstd on genomic data in an apples-to-apples comparison; I'd be really curious to learn more about how you achieved that.
20.
by CreRecombinase 4y ago
These MPI-based scientific computing applications make up a bulk of the compute hours on hpc clusters, but there is a crazy long tail of scientists who have workloads that can’t (or shouldn’t) run on their personal computers. The other opti
21.
by CreRecombinase 4y ago
Roaring bitmaps are compressed bitmaps and they're pretty great. https://roaringbitmap.org/about/
22.
by CreRecombinase 6y ago
You have to understand that many R users don't have root access the the machines they're working on.
23.
by CreRecombinase 6y ago
R packages on CRAN need to be able to install without internet connection so I'm skeptical that that's the case. CRAN packages also don't allow for dependency on R packages that are (only) on github.
24.
by CreRecombinase 6y ago
I would argue that if "reasonably competent" means "gets in accidents less frequently and has fewer moving violations", the "idiot" in the minivan is very likely more competent than the joy rider. Also one pers
25.
by CreRecombinase 6y ago
I often feel like bioinformatics is like this steampunk alternate reality where, because HPC clusters don't generally do database administration, all the technology and the ecosystem has developed has been built on flat files. Let me
26.
by CreRecombinase 6y ago
2 properties at 1 million will probably require more time and effort though, right? Like they may be better off buying 10 200k houses, but the mob lawyer has more important things to do
27.
by CreRecombinase 6y ago
I think the worst thing you could do in this situation is put the redesign people on the infrastructure team
28.
by CreRecombinase 6y ago
That's a bummer. I have an Intel 700 series I got several years ago that I've been torturing on and off for years. Still no problems. I think it was their first NVMe/PCIe drive too. Hell, the haswell era i7 and the god-knows-
29.
by CreRecombinase 6y ago
Joe Derisi is a really incredible scientist. A "founding father" of genomics.
30.
by CreRecombinase 6y ago
R some very lispy meta-programming features. Very briefly, if I'm a function (go with me here) `foo <- function(x,y){whatever}`,and someone calls me, `foo(bar,baz)` I get to know that `baz` is "bound" to `y`. The caller

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