7 ms·
Has anyone done a RCT of D3+K2? K2 seems to be important in the absorption of D3. Another aspect that bothers me with these studies is that we’re simply supplem
by rzz3 3mo ago
Has anyone done a RCT of D3+K2? K2 seems to be important in the absorption of D3. Another aspect that bothers me with these studies is that we’re simply supplementing the vitamin D, seemingly without measuring the change in blood levels. I took 2000IU (+K2) a day for many years in between testing my blood levels and still had <30ng/ml and had to go up to 5000IU/day. I’d like to see some further study.
- nullc 3mo ago> I took 2000IU (+K2) a day for many years in between testing my blood levels and still had <30ng/ml and had to go up to 5000IU/day. Likewise, 23ng/ml while taking 2000iu/day of dry vitamin-d. Switched to 5000iu +K2 in MCT oil, -- 8 months later I'm at 64ng/ml.
- rbjorklin 3mo agoAny noticeable difference how you feel health wise? Energy levels? Mood? Sleep quality?
- _0ffh 3mo agoNot the same person here, but a data point nonetheless. Before supplementing D3 I had a cold basically every year, sometimes twice a year. Since I brushed up my levels I average 1 cold in 6 years.
- ww520 3mo agoOddly, since the Covid time, I haven't caught a cold or flu once. I'm not sure it's the vaccines, the flu shots, or the less physical contacts on things overall. I still go to crowded places from time to time, like plane or train rides. May be the population in general have less cold or flu virus overall to go around.
- nullc 3mo agoUnfortunately too many other changes happened at the same time. I am enormously healthier now (in numerous measurable as well as subjective ways) but it may be that the D levels played no role.
- nicman23 3mo agofor me, i was so deficient that i would notice it the next morning. also probably not a placebo as the D supplement i am taking is not something my mind goes to 7 am pre coffee lol
- icedchai 3mo agoI switched from 2000 to 5000iu about 8 years ago. My levels went up similar to yours, but I don't feel much different!
- brandonb 3mo agoTARGET-D is an in-progress study that supplements vitamin D based on blood levels (your idea).
- nradov 3mo agoI think that study is already concluded but the results haven't been published yet. https://clinicaltrials.gov/study/NCT02996721?tab=study https://clinicaltrials.gov/study/NCT02996721?tab=study
- odie5533 3mo agoWere you taking hard tablets? And were you taking them with a fatty meal? Those are both very important. I take a Vitamin D + K2 softgel with a meal that has some fat in it.
- aaronbrethorst 3mo agoCostco sells D3+K2 softgels! Great price, of course. I started taking them at the recommendation of my podiatrist after I broke my foot last winter (third metatarsal fracture, specifically, ouch).
- amelius 3mo agoWhat I found was that I had to dissolve vit D under the tongue, not immediately swallow it.
- cj 3mo agoK2 is also known to prevent problems with calcium build up which can happen if Vitamin D is dosed too high. I personally would never take Viramin D without K2 alongside it.
- fridder 3mo agoOne problem: folks that are on blood thinners shouldn't supplement with vitamin k
- moffkalast 3mo agoIf you are on blood thinners you probably shouldn't be taking common advice on anything tbf. Or diabetic. Or heavily allergic. Cause you will straight up die.
- freehorse 3mo agoonly if the blood thinners taken are vitamin k antagonists (not all are)
- anjel 3mo agoVitamin k and k2 are not at all the same with respect to blood thinning
- throwaway613746 3mo ago[dead]
- trevorkoob 3mo agoWhen I did my master's thesis on Vitamin D supplementation the conclusion was that vitamin D testing is wildly inaccurate, and we needed to have studies based on a target level - ideally one based around sub-saharan African community levels. As for supplementation, sunlight has been estimated at providing up to 20,000IU per day, which I think (not medical advice due to the lack of study), from a mechanistic point of view, suggests an upper limit to daily supplementation.