7 ms·
Here's the full sequence of the protein, found in the supplement [1] KSSEPASVSAAERRAETEQHKLEQENPGIVWLDQHGRVTAENDVALQILGPAGEQSLGVAQDSLEGIDVVQLHPEKSRDKLRFLLQSKDV
by jfarlow 1y ago
Here's the full sequence of the protein, found in the supplement [1]
KSSEPASVSAAERRAETEQHKLEQENPGIVWLDQHGRVTAENDVALQILGPAGEQSLGVAQDSLEGIDVVQLHPEKSRDKLRFLLQSKDVGGSPVKSPPPVAMMINIPDRILMIKVSSMIAAGGASGTSMIFYDVTDLTTEPSGLPAGGSAPSHHHHHH
It is a protein encoding the PxRcoM-1 heme binding domain with C94S mutation and a C-terminal 6xHis tag (RcoM-HBD-C94S)
[1] https://www.pnas.org/doi/10.1073/pnas.2501389122#supplementary-materials https://www.pnas.org/doi/10.1073/pnas.2501389122#supplementa...
- sunrunner 1y agoThis looks like an puzzle input to a day from Advent of Code.
- meisel 1y agoThanks for that sequence, I can really picture it now
- dekhn 1y agoYou can search for it here: https://alphafold.ebi.ac.uk/search/sequence/KSSEPASVSAAERRAETEQHKLEQENPGIVWLDQHGRVTAENDVALQILGPAGEQSLGVAQDSLEGIDVVQLHPEKSRDKLRFLLQSKDVGGSPVKSPPPVAMMINIPDRILMIKVSSMIAAGGASGTSMIFYDVTDLTTEPSGLPAGGSAPSHHHHHH https://alphafold.ebi.ac.uk/search/sequence/KSSEPASVSAAERRAE... and in principle get the AlphaFold predicted structure (I couldn't find an experimentally determined one). However, like nearly all EBI resources, the web server timed out before I could get a link to the prediction.
- immibis 1y agoIsn't it strange to see protein codes spreading the same way magnet links or AACS encryption keys might.
- winocm 1y agoIf you want to download SARS-CoV-2, here you go: https://www.ncbi.nlm.nih.gov/nuccore/NC_045512.2 https://www.ncbi.nlm.nih.gov/nuccore/NC_045512.2
- mhb 1y agoThat doesn't look right. I think the problem is in the last quarter. Exercise for the reader.
- BurningFrog 1y agoHow hard is it to manufacture once you know the sequence?